INT228272

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Context Info
Confidence 0.62
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 9
Disease Relevance 2.30
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Cd34) cell adhesion (Cd34) cytoplasm (Cd34)
Anatomy Link Frequency
hepatocytes 2
HSCs 1
liver 1
endothelial cells 1
Cd34 (Mus musculus)
Pain Link Frequency Relevance Heat
abdominal pain 1 73.36 Quite High
headache 1 71.04 Quite High
halothane 1 61.04 Quite High
Piles 1 57.84 Quite High
imagery 1 38.00 Quite Low
chemokine 6 25.56 Quite Low
cytokine 28 24.96 Low Low
Inflammation 15 5.00 Very Low Very Low Very Low
anesthesia 7 5.00 Very Low Very Low Very Low
Central nervous system 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 53 99.52 Very High Very High Very High
Myeloid Leukemia 64 99.36 Very High Very High Very High
Hepatotoxicity 40 97.96 Very High Very High Very High
Diabetes Mellitus 21 95.60 Very High Very High Very High
Toxicity 8 90.32 High High
Obesity 6 90.00 High High
Injury 134 89.76 High High
Diarrhoea 1 76.40 Quite High
Vomiting 2 75.60 Quite High
Appetite Loss 2 74.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study, we did not determine whether fusion of G-CSF-mobilized CD34+ HSCs with liver cells was responsible for their hepatocyte-like morphology or whether the cells change their fate in vivo in response to local cues after transplantation.
Localization (mobilized) of CD34 in hepatocyte
1) Confidence 0.62 Published 2010 Journal Stem Cell Res Ther Section Body Doc Link PMC2941114 Disease Relevance 0.13 Pain Relevance 0
Mice were killed 7 or 21 days after transplantation with G-CSF-mobilized CD34+ HSCs.
Localization (mobilized) of CD34
2) Confidence 0.58 Published 2010 Journal Stem Cell Res Ther Section Body Doc Link PMC2941114 Disease Relevance 0 Pain Relevance 0
Furthermore, human-specific ALB mRNA was expressed in the liver, and human ALB was detected in the serum only in the mobilized CD34+ HSCs-treated mice.
Localization (mobilized) of CD34 in liver
3) Confidence 0.58 Published 2010 Journal Stem Cell Res Ther Section Body Doc Link PMC2941114 Disease Relevance 0.14 Pain Relevance 0
These observations proved that transplanted G-CSF-mobilized CD34+ HSCs developed into functional hepatocytes.
Localization (mobilized) of CD34 in hepatocytes
4) Confidence 0.58 Published 2010 Journal Stem Cell Res Ther Section Body Doc Link PMC2941114 Disease Relevance 0 Pain Relevance 0
The mobilized CD34+ HSCs significantly ameliorated radiation-induced liver damage.
Localization (mobilized) of CD34 in HSCs associated with hepatotoxicity
5) Confidence 0.54 Published 2010 Journal Stem Cell Res Ther Section Abstract Doc Link PMC2941114 Disease Relevance 0.36 Pain Relevance 0
Co-localization for type II epithelial cells (surfactant protein C; SpC) or
alveolar endothelial cells (CD34) was performed as described
(17). 
Localization (localization) of CD34 in endothelial cells
6) Confidence 0.48 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2570855 Disease Relevance 0.10 Pain Relevance 0.03
Interestingly, F317L is another emerging mutation that has been observed in dasatinib-resistant patients.48 In addition, although dasatinib significantly inhibits CrkL phosphor-ylation and reduces the total number of CD34+ CD38?
Localization (number) of CD34
7) Confidence 0.38 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2697539 Disease Relevance 1.42 Pain Relevance 0.17
Monoclonal antibodies conjugated with fluorescein isothiocyanate (FITC) or phycoerythrin (PE) were used for the analysis and all antibodies were purchased from BD Pharmingen except for CD34 and CD73 which were obtained from eBioscience.
Neg (except) Localization (purchased) of CD34
8) Confidence 0.37 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2270908 Disease Relevance 0.14 Pain Relevance 0
The cells were incubated overnight sequentially at 4°C with primary antibodies raised against CD105 1:200, mouse (BD Biosciences, San Jose, CA, USA), CD73 1:200, mouse (Santa Cruz Biotecnology, Inc., Santa Cruz, CA, USA), CD90 1:200, mouse (Santa Cruz Biotecnology, Inc., Santa Cruz, CA, USA), and CD34 1:200, mouse (Santa Cruz Biotecnology, Inc., Santa Cruz, CA, USA).
Localization (raised) of CD34
9) Confidence 0.23 Published 2010 Journal Journal of Indian Society of Periodontology Section Body Doc Link PMC2933523 Disease Relevance 0 Pain Relevance 0

General Comments

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