INT22830

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Context Info
Confidence 0.55
First Reported 1990
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 4.80
Pain Relevance 1.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL2) extracellular region (IL2) cell adhesion (IL2)
cell-cell signaling (IL2)
Anatomy Link Frequency
T cells 4
apoptotic cell 2
IL2 (Homo sapiens)
Pain Link Frequency Relevance Heat
palliative 2 100.00 Very High Very High Very High
cytokine 12 98.76 Very High Very High Very High
Arthritis 105 97.04 Very High Very High Very High
Inflammation 19 96.76 Very High Very High Very High
Cluster headache 4 81.84 Quite High
psoriasis 35 81.28 Quite High
rheumatoid arthritis 9 77.56 Quite High
antagonist 1 42.96 Quite Low
anakinra 1 40.04 Quite Low
Inflammatory mediators 1 15.92 Low Low
Disease Link Frequency Relevance Heat
Malignant Neoplastic Disease 10 99.00 Very High Very High Very High
Lung Cancer 6 98.60 Very High Very High Very High
Lymphatic System Cancer 39 98.08 Very High Very High Very High
Pleural Effusion 5 97.88 Very High Very High Very High
Leukemia 4 97.56 Very High Very High Very High
Apoptosis 3 97.56 Very High Very High Very High
Seronegative Spondarthritis 92 97.04 Very High Very High Very High
Death 3 96.96 Very High Very High Very High
INFLAMMATION 18 96.76 Very High Very High Very High
Pleurisy 3 95.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This MAb identifies the IL-2 receptors by blocking the binding of radiolabelled IL-2 to T-cells.
Negative_regulation (blocking) of IL-2 Binding (binding) of in T-cells
1) Confidence 0.55 Published 1990 Journal Headache Section Abstract Doc Link 2335478 Disease Relevance 0.31 Pain Relevance 0.31
In cell lines, it was thought that daclizumab blocked the interaction of IL2 and its receptor resulting in cytokine-deprivation-mediated apoptotic cell death.20 Additionally, based on in vivo data from mouse models, it was thought that daclizumab also exerted an effect through an FcR receptor mechanism.21
Negative_regulation (blocked) of IL2 Binding (interaction) of in apoptotic cell associated with apoptosis, death and cytokine
2) Confidence 0.52 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004568 Disease Relevance 1.66 Pain Relevance 0.09
In order to assess the palliative and therapeutic activity of IL-2 in unresectable pleural malignant mesothelioma with pleural effusion, we performed a phase II study on 31 consecutive patients (M/F 16/15; median age 61 years, range 40-84; PS ECOG 0 n=7; ECOG 1 n=15; ECOG 2 n=9; stage IA n=13; IB n=9; II n=7; IV=2) who received first-line therapy with intrapleural repeated instillation of 9000000 I.U.
Negative_regulation (assess) of IL-2 Binding (activity) of associated with pleural effusion, malignant neoplastic disease, lung cancer and palliative
3) Confidence 0.41 Published 2001 Journal Lung Cancer Section Abstract Doc Link 11165411 Disease Relevance 1.57 Pain Relevance 0.17
-subunit of the IL-2 receptor, blocks the binding of IL-2, a vital growth factor for T cells.
Negative_regulation (blocks) of IL-2 Binding (binding) of in T cells
4) Confidence 0.19 Published 2005 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC1208938 Disease Relevance 1.26 Pain Relevance 0.49

General Comments

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