INT22831

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Context Info
Confidence 0.55
First Reported 1986
Last Reported 2009
Negated 0
Speculated 1
Reported most in Abstract
Documents 7
Total Number 9
Disease Relevance 1.70
Pain Relevance 2.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL2) extracellular region (IL2) cell adhesion (IL2)
cell-cell signaling (IL2)
Anatomy Link Frequency
T cell 6
lymphocyte 2
IL2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 10 99.84 Very High Very High Very High
dexamethasone 1 99.80 Very High Very High Very High
mu opioid receptor 2 98.72 Very High Very High Very High
Serotonin 1 94.96 High High
Inflammation 21 94.44 High High
opioid receptor 7 93.92 High High
antagonist 11 93.44 High High
Cluster headache 4 93.08 High High
cytokine 40 86.08 High High
Pain 1 79.68 Quite High
Disease Link Frequency Relevance Heat
Disease 20 99.66 Very High Very High Very High
INFLAMMATION 21 94.44 High High
Vomiting 6 93.32 High High
Cluster Headache 4 93.08 High High
Chills 1 92.60 High High
Fever 5 92.28 High High
Cancer 9 86.52 High High
Renal Cancer 4 75.00 Quite High
Herpes Zoster 4 75.00 Quite High
Hypoxia 2 43.28 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inhibition of IL-2 activation by PB was demonstrated to result from a blockade of the mitogenic growth factor signal using the IL-2-dependent cell line HT-2.
Negative_regulation (Inhibition) of Positive_regulation (activation) of IL-2
1) Confidence 0.55 Published 1986 Journal Transplantation Section Abstract Doc Link 3097893 Disease Relevance 0 Pain Relevance 0.21
In contrast to this, after one week of placebo treatment, a significant decrease in the patients' lymphoproliferative response to IL-2 could be observed as compared to patients' initial responses (p < 0.05) or to those of controls (p < 0.05).
Negative_regulation (decrease) of Positive_regulation (response) of IL-2
2) Confidence 0.42 Published 1994 Journal Asian Pac. J. Allergy Immunol. Section Abstract Doc Link 7872992 Disease Relevance 0.35 Pain Relevance 0.08
This phenomenon led to an investigation of the phenotypic expression of PBL before and after IL-2 incubation, and of the IL-2 lymphocyte receptor.
Spec (investigation) Negative_regulation (investigation) of Positive_regulation (incubation) of IL-2 in lymphocyte
3) Confidence 0.40 Published 1990 Journal Headache Section Abstract Doc Link 2335478 Disease Relevance 0.32 Pain Relevance 0.32
These complications were acceptable, even in the patients with concomitant disease, and completely disappeared after cessation of IL-2.
Negative_regulation (disappeared) of Positive_regulation (cessation) of IL-2 associated with disease
4) Confidence 0.37 Published 1996 Journal Cancer Biother. Radiopharm. Section Abstract Doc Link 10851506 Disease Relevance 0.82 Pain Relevance 0.12
We found that dexamethasone markedly inhibited the IL-2 induced cytotoxicity and the IL-2-induced-ADCC.
Negative_regulation (inhibited) of Positive_regulation (induced) of IL-2 associated with dexamethasone
5) Confidence 0.27 Published 2007 Journal Cell. Immunol. Section Abstract Doc Link 17562330 Disease Relevance 0.09 Pain Relevance 0.47
Furthermore, we demonstrated that the induction of interleukin-2 mRNA and protein in activated T cells was inhibited by morphine in cells, in which mu-opioid receptors had been induced by CD3/28 monoclonal antibodies (mAbs), and that this effect was blocked by the mu-opioid receptor-specific antagonist D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH(2).
Negative_regulation (inhibited) of Positive_regulation (induction) of interleukin-2 in T cells associated with antagonist, mu opioid receptor, opioid receptor and morphine
6) Confidence 0.26 Published 2008 Journal Mol. Pharmacol. Section Abstract Doc Link 18463202 Disease Relevance 0 Pain Relevance 0.87
In addition, we also found that chronic morphine treatment inhibited the acetylation and trimethylation of histones and decreased both DNA demethylation and accessibility of the IL-2 promoter.
Negative_regulation (decreased) of Positive_regulation (accessibility) of IL-2 associated with morphine
7) Confidence 0.15 Published 2007 Journal J. Biol. Chem. Section Abstract Doc Link 17227776 Disease Relevance 0 Pain Relevance 0.56
The immunosuppressive activity of sirolimus activity is primarily related to blockade of IL-2 and IL-15 induction of B and T cell proliferation via inhibition of p70S6 kinase through high affinity binding to FKBP and prevents progression of the cell cycle from the G1 to S phase.
Negative_regulation (blockade) of Positive_regulation (induction) of IL-2 in T cell
8) Confidence 0.10 Published 2009 Journal Journal of Transplantation Section Body Doc Link PMC2809333 Disease Relevance 0.06 Pain Relevance 0
The immunosuppressive activity of sirolimus activity is primarily related to blockade of IL-2 and IL-15 induction of B and T cell proliferation via inhibition of p70S6 kinase through high affinity binding to FKBP and prevents progression of the cell cycle from the G1 to S phase.
Negative_regulation (inhibition) of Positive_regulation (induction) of IL-2 in T cell
9) Confidence 0.07 Published 2009 Journal Journal of Transplantation Section Body Doc Link PMC2809333 Disease Relevance 0.06 Pain Relevance 0

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