INT228328

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Context Info
Confidence 0.34
First Reported 2008
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 7
Total Number 9
Disease Relevance 0.27
Pain Relevance 1.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PYCARD) signal transduction (PYCARD) intracellular (PYCARD)
cytoplasm (PYCARD)
Anatomy Link Frequency
row 2
HeLa 2
upper 2
PYCARD (Homo sapiens)
Pain Link Frequency Relevance Heat
Transcranial magnetic stimulation 285 100.00 Very High Very High Very High
nerve block 79 99.98 Very High Very High Very High
Inflammation 36 83.40 Quite High
addiction 6 76.64 Quite High
Dopamine 3 58.44 Quite High
agonist 120 48.72 Quite Low
opiate 3 39.72 Quite Low
Potency 15 27.68 Quite Low
Pain 21 5.00 Very Low Very Low Very Low
beta blocker 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 50 83.72 Quite High
INFLAMMATION 36 83.40 Quite High
Pulmonary Disease 33 53.32 Quite High
Asthma 57 52.96 Quite High
Syndrome 27 43.00 Quite Low
Fever 33 5.00 Very Low Very Low Very Low
Pain 19 5.00 Very Low Very Low Very Low
Airway Obstruction 12 5.00 Very Low Very Low Very Low
Osteomyelitis 12 5.00 Very Low Very Low Very Low
Stress 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Comparing Standard and Reversed TMS (Fig. 3), the motor threshold was higher for Reversed TMS (Fig8 coil: mean difference?
Positive_regulation (higher) of Gene_expression (coil) of TMS associated with transcranial magnetic stimulation
1) Confidence 0.34 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2271126 Disease Relevance 0 Pain Relevance 0.43
When TMS was applied with identical stimulation parameters at different times, the morphology and the spatial-temporal dynamics of TMS-evoked potentials were largely preserved (Fig. 2, fourth row).
Positive_regulation (When) of Gene_expression (applied) of TMS in row associated with transcranial magnetic stimulation
2) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2858649 Disease Relevance 0 Pain Relevance 0.20
In the SB experiment TMS was applied over five different regions.
Positive_regulation (experiment) of Gene_expression (applied) of TMS associated with nerve block
3) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2952623 Disease Relevance 0 Pain Relevance 0.50
The presence of a single homologous region shared by Asc transporters and three classes of aminergic receptors that are enhanced by Asc (Figure 12, upper panel) suggested that extracellular loop regions of the receptors might be responsible for their Asc sensitivity.
Spec (might) Positive_regulation (responsible) of Gene_expression (sensitivity) of Asc in upper
4) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001466 Disease Relevance 0.11 Pain Relevance 0.03
Epi produces a significant relaxation in both cases, but the presence of Epi + Asc results in a deeper relaxation than Epi alone.
Positive_regulation (results) of Gene_expression (presence) of Asc
5) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001466 Disease Relevance 0 Pain Relevance 0.04
The lower lines, most clearly seen in the 100 Asc series, are produced as the Asc is oxidized in the absence of AR.
Positive_regulation (absence) of Gene_expression (oxidized) of Asc
6) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001466 Disease Relevance 0 Pain Relevance 0
Indeed, in earlier studies, we demonstrated that, in HeLa cells (which do not express PSTPIP1) co-transfection of pyrin and ASC promotes ASC speck formation [32].
Positive_regulation (transfection) of Gene_expression (transfection) of ASC in HeLa
7) Confidence 0.14 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2702820 Disease Relevance 0.17 Pain Relevance 0.04
Moreover, in cells transfected with PSTPIP1 and ASC, PSTPIP1 is never observed in specks (Figure 9E–G), indicating that PSTPIP1 never visits the inflammasome in the absence of pyrin.
Positive_regulation (transfected) of Gene_expression (transfected) of ASC
8) Confidence 0.12 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2702820 Disease Relevance 0 Pain Relevance 0
When ASC specks form in cells transfected with ASC and pyrin, both proteins are always co-localized in the specks (Figure 9A–D).
Positive_regulation (transfected) of Gene_expression (transfected) of ASC
9) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2702820 Disease Relevance 0 Pain Relevance 0

General Comments

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