INT228333

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Context Info
Confidence 0.04
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.53
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IRF9) nucleoplasm (IRF9) nucleus (IRF9)
cytoplasm (IRF9)
Anatomy Link Frequency
nucleus 1
IFNA1 (Homo sapiens)
IRF9 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 2 68.04 Quite High
fibrosis 5 54.56 Quite High
Multiple sclerosis 20 45.60 Quite Low
anesthesia 1 10.48 Low Low
Central nervous system 1 8.32 Low Low
Inflammation 1 6.80 Low Low
imagery 3 5.00 Very Low Very Low Very Low
depression 2 5.00 Very Low Very Low Very Low
Bioavailability 1 5.00 Very Low Very Low Very Low
antidepressant 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatitis C Virus Infection 91 65.36 Quite High
Hepatotoxicity 3 63.72 Quite High
Disease 11 62.96 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 22 58.32 Quite High
Fibrosis 2 54.56 Quite High
Cirrhosis 6 51.40 Quite High
Demyelinating Disease 22 50.00 Quite Low
Chronic Hepatitis 1 50.00 Quite Low
Injury 1 49.20 Quite Low
Infection 1 42.32 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The activated STAT1/2 complex then migrates to the cell nucleus, forming a complex with IFN-regulatory factor 9 (IRF-9) where interaction with cellular DNA leads to expression of IFN-stimulated genes (ISGs).
IFN Binding (complex) of IRF-9 in nucleus
1) Confidence 0.04 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621394 Disease Relevance 0.47 Pain Relevance 0.09
One pathway, leads to activation of the transcription factor IFN-stimulated gene factor 3 (ISGF3), a complex of phosphorylated Signal Transducer and Activator of Transcription (STAT) 2 with STAT1 and IFN regulatory factor 9 (IRF-9; p48) that binds to the IFN-stimulated response element (ISRE) present in multiple genes.[8], [9] The other pathway involves STAT2/1 and STAT2/3 heterodimers and STAT1 homodimer (IFN-?
IFN Binding (binds) of IRF-9
2) Confidence 0.04 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2271130 Disease Relevance 0.06 Pain Relevance 0

General Comments

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