INT22834

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Context Info
Confidence 0.58
First Reported 1986
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 28
Total Number 29
Disease Relevance 23.07
Pain Relevance 7.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (CYP21A2) endoplasmic reticulum (CYP21A2)
Anatomy Link Frequency
brain 2
testis 1
CYP21A2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dopamine 31 99.88 Very High Very High Very High
Serotonin 91 99.70 Very High Very High Very High
noradrenaline 50 99.50 Very High Very High Very High
qutenza 16 99.40 Very High Very High Very High
depression 208 97.80 Very High Very High Very High
fluoxetine 58 96.62 Very High Very High Very High
sSRI 104 96.14 Very High Very High Very High
monoamine 53 95.52 Very High Very High Very High
cocaine 7 94.64 High High
antidepressant 189 92.44 High High
Disease Link Frequency Relevance Heat
Congenital Adrenal Hyperplasia 81 99.92 Very High Very High Very High
Adrenal Cancer 849 99.84 Very High Very High Very High
Fabry Disease 44 99.84 Very High Very High Very High
Hypertension 94 99.64 Very High Very High Very High
Recurrence 18 99.38 Very High Very High Very High
Disease 82 98.84 Very High Very High Very High
Addisons Disease 1 98.72 Very High Very High Very High
Cancer 40 98.70 Very High Very High Very High
Hyperplasia 10 98.68 Very High Very High Very High
Phenylketonuria 28 98.66 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
With decreased P450c21 activity, conversions of 17-hydroxyprogesterone (17-OHP) to 11-deoxycortisol, and progesterone (P4) to deoxycorticosterone, are impaired.
Negative_regulation (decreased) of P450c21
1) Confidence 0.58 Published 2010 Journal International Journal of Pediatric Endocrinology Section Body Doc Link PMC2910408 Disease Relevance 0.80 Pain Relevance 0
Nevertheless, utilizing rigid criteria to distinguish among salt wasting, simple virilizing and NCAH can be problematic because impaired 21-hydroxylase function represents a continuum of decreased enzyme activity.

3.

Negative_regulation (impaired) of 21-hydroxylase associated with adrenal cancer
2) Confidence 0.57 Published 2010 Journal International Journal of Pediatric Endocrinology Section Body Doc Link PMC2910408 Disease Relevance 0.80 Pain Relevance 0
Thus, the acute ACTH stimulation test remains the gold standard to confirm decreased 21-hydroxylase activity.
Negative_regulation (decreased) of 21-hydroxylase
3) Confidence 0.57 Published 2010 Journal International Journal of Pediatric Endocrinology Section Body Doc Link PMC2910408 Disease Relevance 0.98 Pain Relevance 0.04
We report a morphological and biochemical analysis of a patient with 21-hydroxylase deficiency who developed bilateral nodular hyperplasia of steroid-secreting tissue within the testis, despite suppression therapy with both exogenous glucocorticoids and testosterone.
Negative_regulation (deficiency) of 21-hydroxylase in testis associated with hyperplasia
4) Confidence 0.42 Published 1990 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 2335578 Disease Relevance 0.44 Pain Relevance 0
The exact mechanism to explain why some individuals with CAH due to 21-hydroxylase deficiency develop hypertension is unclear, and further investigation is warranted.

5.

Negative_regulation (deficiency) of 21-hydroxylase associated with hypertension and adrenal cancer
5) Confidence 0.42 Published 2010 Journal International Journal of Pediatric Endocrinology Section Body Doc Link PMC2817857 Disease Relevance 1.63 Pain Relevance 0
Growth and Reproductive Outcomes in Congenital Adrenal Hyperplasia

The treatment of congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency is complex.

Negative_regulation (deficiency) of 21-hydroxylase associated with adrenal cancer
6) Confidence 0.42 Published 2010 Journal International Journal of Pediatric Endocrinology Section Title Doc Link PMC2817857 Disease Relevance 0.91 Pain Relevance 0
Adrenal causes include Cushing's syndrome, androgen-producing tumors, and congenital adrenal hyperplasia (CAH), most commonly due to 21-hydroxylase deficiency.
Negative_regulation (deficiency) of 21-hydroxylase associated with cancer, syndrome and adrenal cancer
7) Confidence 0.42 Published 2010 Journal Indian Journal of Dermatology Section Body Doc Link PMC2856356 Disease Relevance 2.00 Pain Relevance 0.04
Cytochrome P450c21 (CYP21A2) deficiency precludes aldosterone and cortisol synthesis, limiting steroidogenesis to the reactions catalyzed by 3?
Negative_regulation (deficiency) of Cytochrome P450c21
8) Confidence 0.42 Published 2010 Journal International Journal of Pediatric Endocrinology Section Body Doc Link PMC2896848 Disease Relevance 0.55 Pain Relevance 0.07
The most common cause of CAH is 21-hydroxylase deficiency (21-OHD) [1], which afflicts about 1?
Negative_regulation (deficiency) of 21-hydroxylase associated with congenital adrenal hyperplasia
9) Confidence 0.42 Published 2010 Journal International Journal of Pediatric Endocrinology Section Body Doc Link PMC2896848 Disease Relevance 0.53 Pain Relevance 0
Functional analysis of mutations associated with NCAH generally indicates a 50–80% loss of enzymatic (21-hydroxylase) function.
Negative_regulation (loss) of 21-hydroxylase associated with adrenal cancer
10) Confidence 0.42 Published 2010 Journal International Journal of Pediatric Endocrinology Section Body Doc Link PMC2910408 Disease Relevance 0.84 Pain Relevance 0
Ninety-one patients with 21-hydroxylase deficiency were identified.
Negative_regulation (deficiency) of 21-hydroxylase
11) Confidence 0.42 Published 2010 Journal International Journal of Pediatric Endocrinology Section Body Doc Link PMC2817857 Disease Relevance 2.18 Pain Relevance 0
The underlying deficiency of 21-hydroxylase leads to overproduction of 17-OH-progesterone and androstendione.


Negative_regulation (deficiency) of 21-hydroxylase
12) Confidence 0.42 Published 2010 Journal International Journal of Trichology Section Body Doc Link PMC3002408 Disease Relevance 1.67 Pain Relevance 0
Of three patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency, two became pregnant and delivered normal children through cesarian section.
Negative_regulation (deficiency) of 21-hydroxylase associated with adrenal cancer
13) Confidence 0.42 Published 1997 Journal Fertil. Steril. Section Abstract Doc Link 9022594 Disease Relevance 0.39 Pain Relevance 0.08
Nonclassic 21-hydroxylase deficiency in Croatia.
Negative_regulation (deficiency) of 21-hydroxylase
14) Confidence 0.42 Published 2004 Journal J. Pediatr. Endocrinol. Metab. Section Title Doc Link 15055349 Disease Relevance 0.32 Pain Relevance 0.08
She resulted carrier of partial 21-hydroxylase deficiency.
Spec (partial) Negative_regulation (deficiency) of 21-hydroxylase
15) Confidence 0.42 Published 2009 Journal Minerva Pediatr. Section Abstract Doc Link 19794382 Disease Relevance 1.51 Pain Relevance 0.08
In both untreated and 3-methylcholanthrene-treated neonatal rat epidermal microsomes, capsaicin resulted in a dose-dependent inhibition of aryl hydrocarbon hydroxylase activity with an I50 value of 3.0 X 10(-4)-3.6 X 10(-4) M.
Negative_regulation (inhibition) of hydroxylase associated with qutenza
16) Confidence 0.33 Published 1986 Journal Drug Metab. Dispos. Section Abstract Doc Link 2873987 Disease Relevance 0 Pain Relevance 0.53
In addition, because chronic fluoxetine treatment is thought to enhance serotonergic neurotransmission, for contrast an additional group of rats were treated with parachlorophenylalanine (PCPA), a tryptophan hydroxylase inhibitor that depletes serotonin.
Negative_regulation (inhibitor) of hydroxylase associated with serotonin and fluoxetine
17) Confidence 0.32 Published 1996 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 8848441 Disease Relevance 0.55 Pain Relevance 0.41
Cytochrome P450c21 (CYP21A2) deficiency precludes aldosterone and cortisol synthesis, limiting steroidogenesis to the reactions catalyzed by 3?
Negative_regulation (deficiency) of CYP21A2
18) Confidence 0.32 Published 2010 Journal International Journal of Pediatric Endocrinology Section Body Doc Link PMC2896848 Disease Relevance 0.55 Pain Relevance 0.07
A Lineweaver-Burk plot of the inhibition of aryl hydrocarbon hydroxylase activity suggested that the inhibition is of the noncompetitive type with Ki value of 50 microM.
Negative_regulation (inhibition) of hydroxylase
19) Confidence 0.24 Published 1986 Journal Drug Metab. Dispos. Section Abstract Doc Link 2873987 Disease Relevance 0 Pain Relevance 0.62
Quinidine, a potent inhibitor of P450 2D6, inhibited the demethylation of each enantiomer by only approximately 20% at a concentration 300 times greater than the Ki determined for the quinidine inhibition of bufuralol 1'-hydroxylase.
Negative_regulation (inhibition) of hydroxylase
20) Confidence 0.19 Published 1993 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8355218 Disease Relevance 0 Pain Relevance 0.61

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