INT22836

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Context Info
Confidence 0.59
First Reported 1990
Last Reported 2010
Negated 2
Speculated 2
Reported most in Body
Documents 9
Total Number 11
Disease Relevance 2.30
Pain Relevance 1.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (F2) extracellular space (F2) extracellular region (F2)
Anatomy Link Frequency
muscle 2
fat 1
endothelial cells 1
synapse 1
F2 (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 3 98.24 Very High Very High Very High
Inflammation 141 98.00 Very High Very High Very High
Analgesic 2 95.36 Very High Very High Very High
Central nervous system 1 93.72 High High
tetrodotoxin 12 93.36 High High
depression 2 92.52 High High
agonist 7 91.80 High High
antagonist 4 84.68 Quite High
Inflammatory response 15 84.08 Quite High
substance P 17 79.16 Quite High
Disease Link Frequency Relevance Heat
Cancer 13 99.20 Very High Very High Very High
INFLAMMATION 155 98.00 Very High Very High Very High
Fever 1 96.12 Very High Very High Very High
Disorder Of Lipid Metabolism 18 94.44 High High
Depression 2 92.52 High High
Microphthalmia 23 89.96 High High
Hyperlipoproteinemia Type Ii 47 89.04 High High
Hyperlipidemia 22 88.16 High High
Granuloma 1 86.72 High High
Pressure And Volume Under Development 3 85.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest that thrombin or a thrombin-like molecule released from muscle is required for activity-dependent synapse elimination and is regulated by neuromuscular activity.
Regulation (regulated) of thrombin in synapse
1) Confidence 0.59 Published 1997 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 9125468 Disease Relevance 0 Pain Relevance 0.33
We present a series of experiments examining whether prothrombin and/or PN1 gene expression, as well as thrombin activity, are regulated in muscle cultures by acetylcholine (ACh) receptor activation.
Spec (whether) Regulation (regulated) of thrombin in muscle
2) Confidence 0.43 Published 1997 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 9125468 Disease Relevance 0 Pain Relevance 0.20
We present a series of experiments examining whether prothrombin and/or PN1 gene expression, as well as thrombin activity, are regulated in muscle cultures by acetylcholine (ACh) receptor activation.
Spec (whether) Regulation (regulated) of prothrombin in muscle
3) Confidence 0.43 Published 1997 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 9125468 Disease Relevance 0 Pain Relevance 0.20
The extract did not produce any significant changes in prothrombin time and fibrinogen level.
Neg (not) Regulation (changes) of prothrombin
4) Confidence 0.22 Published 1990 Journal J Ethnopharmacol Section Abstract Doc Link 2335958 Disease Relevance 0.44 Pain Relevance 0.31
In human vascular endothelial cells both thrombin and PAR1-AP elicited gene regulation via E-box signaling [62].
Regulation (regulation) of thrombin in endothelial cells
5) Confidence 0.16 Published 2007 Journal BMC Immunol Section Body Doc Link PMC2000913 Disease Relevance 0.49 Pain Relevance 0.20
Thrombin-induced regulation of Rho and Rac in CS-stimulated pulmonary EC cultures has also been described in detail in our previous publications [23].
Regulation (regulation) of Thrombin
6) Confidence 0.09 Published 2008 Journal Crit Care Section Body Doc Link PMC2374596 Disease Relevance 0.08 Pain Relevance 0
OBJECTIVE: To investigate the effect of co-administration of the non-steroidal anti-inflammatory drug (NSAID) lornoxicam on the pharmacokinetics of (R)- and (S)-phenprocoumon and their effect on factor II and VII activities.
Regulation (effect) of factor II associated with inflammation and cinod
7) Confidence 0.08 Published 1999 Journal Eur. J. Clin. Pharmacol. Section Abstract Doc Link 10027661 Disease Relevance 0.10 Pain Relevance 0.15
Despite these changes in pharmacokinetics, a decrease of the effect on factor II and VII activity was observed.
Regulation (effect) of factor II
8) Confidence 0.08 Published 1999 Journal Eur. J. Clin. Pharmacol. Section Body Doc Link 10027661 Disease Relevance 0 Pain Relevance 0
A strong correlation exists between PAR mediating the response of thrombin and u-PAR-mediated cancer cell migration/invasion [42].
Regulation (response) of thrombin associated with cancer
9) Confidence 0.04 Published 2007 Journal BMC Physiol Section Body Doc Link PMC1853107 Disease Relevance 0.32 Pain Relevance 0.10
In addition, ezetimibe has no effect on the plasma concentrations of the fat-soluble vitamins A, D, and E and on the prothrombin time, and it does not impair adrenocortical steroid hormone production.1
Neg (no) Regulation (effect) of prothrombin in fat
10) Confidence 0.04 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2988620 Disease Relevance 0.87 Pain Relevance 0
Contrary to what was expected from the changes in pharmacokinetics, a statistically significant decrease in the effect of phenprocoumon on factor II and VII activity was observed for the sessions with lornoxicam co-administration.
Regulation (effect) of factor II
11) Confidence 0.01 Published 1999 Journal Eur. J. Clin. Pharmacol. Section Body Doc Link 10027661 Disease Relevance 0 Pain Relevance 0

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