INT228376

Context Info Confidence 0.45 First Reported 2008 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 2.20 Pain Relevance 0.07

intracellular (Tlr3) cytoplasm (Tlr3)

Tlr3 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Inflammatory mediators 1 81.52 Inflammation 13 51.16 cytokine 6 5.00 fifth nerve 3 5.00 trigeminal ganglion 2 5.00 isoflurane 2 5.00 Central nervous system 1 5.00 carbamazepine 1 5.00 anesthesia 1 5.00 cINOD 1 5.00

Disease Link Frequency Relevance Heat Staphylococcus Infection 49 98.86 Syndrome 56 98.78 INFLAMMATION 17 81.12 Blindness 1 78.72 Disease 6 76.88 Viral Infection 1 68.20 Sprains And Strains 47 66.00 Herpes Simplex Virus 4 50.00 Conjunctivitis 1 48.08 Bacterial Respiratory Disease 1 38.92

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Tlr3 expressed in cell endosomes recognizes double-stranded RNA.

Tlr3 Binding (recognizes) of

1) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929186 Disease Relevance 0.34 Pain Relevance 0.04

We also documented that in Japanese SJS/TEN patients with ocular surface complications there was an association with TLR3 polymorphisms [2] and with IL4R polymorphisms [14].

TLR3 Binding (association) of associated with staphylococcus infection and syndrome

2) Confidence 0.03 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2274925 Disease Relevance 1.86 Pain Relevance 0.03

General Comments

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