INT22838

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Context Info
Confidence 0.25
First Reported 1990
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 26
Total Number 26
Disease Relevance 19.90
Pain Relevance 3.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Fgg) extracellular space (Fgg) extracellular region (Fgg)
protein binding, bridging (Fgg)
Anatomy Link Frequency
plasma 3
platelets 2
blood 1
Scarpa's ganglion 1
nerve 1
Fgg (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 47 99.92 Very High Very High Very High
spinal inflammation 14 99.68 Very High Very High Very High
rheumatoid arthritis 247 99.56 Very High Very High Very High
Inflammation 332 99.28 Very High Very High Very High
Demyelination 2 97.52 Very High Very High Very High
Analgesic 5 96.96 Very High Very High Very High
Bile 10 95.68 Very High Very High Very High
Inflammatory mediators 9 95.20 Very High Very High Very High
cva 65 94.76 High High
Central nervous system 1 94.68 High High
Disease Link Frequency Relevance Heat
Shock 8 99.78 Very High Very High Very High
Ankylosing Spondylitis 14 99.68 Very High Very High Very High
Rheumatoid Arthritis 249 99.56 Very High Very High Very High
Chronic Renal Failure 62 99.50 Very High Very High Very High
INFLAMMATION 361 99.28 Very High Very High Very High
Infection 45 98.96 Very High Very High Very High
Anaemia 56 98.86 Very High Very High Very High
Coagulation Disorder 6 98.54 Very High Very High Very High
Disease 126 98.52 Very High Very High Very High
Increased Venous Pressure Under Development 156 98.30 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The extract did not produce any significant changes in prothrombin time and fibrinogen level.
Neg (not) Gene_expression (produce) of fibrinogen
1) Confidence 0.25 Published 1990 Journal J Ethnopharmacol Section Abstract Doc Link 2335958 Disease Relevance 0.45 Pain Relevance 0.31
Higher plasma fibrinogen and CRP levels in the acute phase, longer BERA latency and I-III interval and increased gadolinium uptake in the vestibular nerve and Scarpa's ganglion on enhanced MRI confirm the inflammatory nature of the process.
Gene_expression (levels) of plasma fibrinogen in Scarpa's ganglion associated with ganglion cysts and inflammation
2) Confidence 0.17 Published 2005 Journal Rev Laryngol Otol Rhinol (Bord) Section Abstract Doc Link 16496559 Disease Relevance 1.25 Pain Relevance 0.45
They had higher levels of IL-6, CRP, fibrinogen, white cell count, and glucose.


Gene_expression (levels) of fibrinogen
3) Confidence 0.09 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2730573 Disease Relevance 1.02 Pain Relevance 0
The crude increase in the odds of death or disability per unit increase in marker level was lowest for CRP and highest for fibrinogen, though the range of the fibrinogen (1.2–9.6 g/l) was smaller than CRP (0.159–263 mg/l).
Gene_expression (range) of fibrinogen associated with death
4) Confidence 0.09 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2730573 Disease Relevance 0.69 Pain Relevance 0
There were also significantly higher CRP, IL-6, fibrinogen, and von Willebrand factor levels in the AS group.
Gene_expression (levels) of fibrinogen associated with spinal inflammation
5) Confidence 0.08 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2515420 Disease Relevance 1.96 Pain Relevance 0.52
Some trials have demonstrated that lowering plasma fibrinogen levels will result in a decreased risk of vascular events [3].
Gene_expression (levels) of fibrinogen in plasma
6) Confidence 0.07 Published 2010 Journal The Open Neurology Journal Section Body Doc Link PMC2923338 Disease Relevance 1.08 Pain Relevance 0.12
Several drugs that are used in VD prevention (e.g., lipid lowering agents and antihypertensives) may influence plasma fibrinogen levels.
Gene_expression (levels) of fibrinogen in plasma associated with increased venous pressure under development
7) Confidence 0.07 Published 2010 Journal The Open Neurology Journal Section Body Doc Link PMC2923338 Disease Relevance 0.95 Pain Relevance 0.10
Whatever the case, the measurement of plasma fibrinogen levels is likely to provide a more comprehensive estimation of risk.
Gene_expression (levels) of fibrinogen in plasma
8) Confidence 0.07 Published 2010 Journal The Open Neurology Journal Section Body Doc Link PMC2923338 Disease Relevance 0.87 Pain Relevance 0.07
In the present study, the LPS plus nanoparticle groups, specifically the LPS + 14-nm nanoparticle group, showed significantly higher fibrinogen levels compared with the LPS group.
Gene_expression (levels) of fibrinogen
9) Confidence 0.07 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1570092 Disease Relevance 0.35 Pain Relevance 0.08
Interestingly, exposure to nanoparticles alone did not induce significant fibrinogen production/release or activate vWF.
Gene_expression (production) of fibrinogen
10) Confidence 0.07 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1570092 Disease Relevance 0.38 Pain Relevance 0.11
No differences were apparent between the two samples when spread on fibrinogen ± thrombin or collagen indicating that cortactin distribution is normal in these cells.
Gene_expression (spread) of fibrinogen
11) Confidence 0.06 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC2203996 Disease Relevance 0.26 Pain Relevance 0
Spreading of HS1-/- platelets on CRP, collagen, fibrinogen or a combination of fibrinogen and thrombin was indistinguishable to that of wild type (WT) platelets both in terms of morphology and surface area (Figure 2A and2B).
Gene_expression (Spreading) of fibrinogen in platelets
12) Confidence 0.06 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC2203996 Disease Relevance 0.06 Pain Relevance 0.05
Patients with RA have increased serum levels of fibrinogen, von Willebrand factor and tissue plasminogen activator antigen compared with controls and these prothrombotic markers have been shown to predict cardiovascular events in patients with RA (McEntegart et al 2001; Sattar et al 2003).


Gene_expression (levels) of fibrinogen associated with rheumatoid arthritis
13) Confidence 0.06 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2515420 Disease Relevance 1.49 Pain Relevance 0.33
Higher plasma fibrinogen and CRP levels in the acute phase, longer BERA latency and I-III interval and increased gadolinium uptake in the vestibular nerve and Scarpa's ganglion on enhanced MRI confirm the inflammatory nature of the process.
Gene_expression (levels) of plasma fibrinogen in nerve associated with ganglion cysts and inflammation
14) Confidence 0.06 Published 2005 Journal Rev Laryngol Otol Rhinol (Bord) Section Abstract Doc Link 16496559 Disease Relevance 1.25 Pain Relevance 0.45
Expression of various toll like receptors (TLR) on astrocytes endows the ability to recognize not only bacterial and viral signals but also endogenous "danger" signals such as heat shock proteins, fibrinogen degradation products, and free DNA [30].
Gene_expression (products) of fibrinogen in astrocytes associated with shock
15) Confidence 0.04 Published 2007 Journal J Transl Med Section Body Doc Link PMC1914111 Disease Relevance 0.70 Pain Relevance 0.18
Indeed, the liver is the primary organ for the synthesis of many different proteins, such as plasma albumin, fibrinogen and most globulins, as well as lipids and lipoproteins (phospholipids, cholesterol) and is responsible for bile acid production and excretion.
Gene_expression (synthesis) of fibrinogen in bile associated with bile
16) Confidence 0.03 Published 2009 Journal Proteome Sci Section Body Doc Link PMC2752743 Disease Relevance 0 Pain Relevance 0.05
-fibrinogen), which is present in ?
Gene_expression (present) of fibrinogen
17) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2861630 Disease Relevance 0.13 Pain Relevance 0
Biotinylated citrullinated fibrinogen (CFb) was produced as previously reported [43] and tested for specificity using pooled sera from three ACPA+ and three ACPA?
Gene_expression (produced) of fibrinogen
18) Confidence 0.02 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621263 Disease Relevance 0.09 Pain Relevance 0.05
Several activities similar to or directed against blood clotting factors have been identified in LA: fibrinolytic enzymes, which degrade fibrinogen producing abnormal FDPs; prothrombin activators: one direct and one factor Xa-like; a thermostable factor V activator; a thermolabile factor V inhibitor; a factor XIII proteolytic/urokinase-like activity; and a kallikrein-like activitiy.
Gene_expression (producing) of fibrinogen in blood associated with coagulation disorder
19) Confidence 0.01 Published 2000 Journal Biochimie Section Abstract Doc Link 11086223 Disease Relevance 0.63 Pain Relevance 0.11
Hematological tests show: mild anemia with leucocytosis; prolonged PT, PTT and ThT; decreased fibrinogen, factor V, factor XIII, plasminogen and alpha2-antiplasmin levels; increased factor VIII:c, von Willebrand factor, and FDPs/D-dimers levels with normal ATIII and platelets.
Gene_expression (levels) of fibrinogen in platelets associated with anaemia
20) Confidence 0.01 Published 2000 Journal Biochimie Section Abstract Doc Link 11086223 Disease Relevance 0.72 Pain Relevance 0.14

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