INT228400

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Context Info
Confidence 0.32
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.76
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transferase activity, transferring glycosyl groups (Ugcg) Golgi apparatus (Ugcg) lipid metabolic process (Ugcg)
Anatomy Link Frequency
neurons 2
anterior pituitary 2
Ugcg (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 17 100.00 Very High Very High Very High
central sensitization 2 97.26 Very High Very High Very High
medulla 2 96.60 Very High Very High Very High
Catecholamine 16 22.64 Low Low
Dopamine 6 16.80 Low Low
monoamine 26 16.16 Low Low
Neuropeptide 2 5.80 Low Low
corticosteroid 9 5.00 Very Low Very Low Very Low
Inflammatory response 7 5.00 Very Low Very Low Very Low
Inflammation 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 50 100.00 Very High Very High Very High
Stress 191 99.98 Very High Very High Very High
Body Weight 14 98.48 Very High Very High Very High
Syndrome 2 87.84 High High
Neurocysticercosis 30 50.00 Quite Low
Shock 2 38.88 Quite Low
Lymphopenia 14 5.00 Very Low Very Low Very Low
INFLAMMATION 13 5.00 Very Low Very Low Very Low
Disease 6 5.00 Very Low Very Low Very Low
Worm Infection 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, we hypothesize that shipment also exaggerates the HPA axis responsiveness for approximately three weeks due to central sensitization of CRF-releasing neurons in the pPVN followed by a phase of reduced CRF release four weeks after shipment that prevents an acute stress-induced release of GCs.


Positive_regulation (induced) of Localization (release) of GCs in neurons associated with stress and central sensitization
1) Confidence 0.32 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2845127 Disease Relevance 0.83 Pain Relevance 0.05
The activation of the hypothalamus-pituitary-adrenal axis (HPA axis) during stress stimulates the release of glucocorticoids (GCs) from the adrenal cortex after adrenocorticotrope hormone (ACTH) is secreted from the anterior pituitary [11-13].
Positive_regulation (stimulates) of Localization (release) of GCs in anterior pituitary associated with stress
2) Confidence 0.21 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2845127 Disease Relevance 0.44 Pain Relevance 0.05
Fate of lectin specific GCs after CNS infection
Positive_regulation (infection) of Localization (Fate) of GCs associated with central nervous system and infection
3) Confidence 0.08 Published 2008 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2274955 Disease Relevance 0.49 Pain Relevance 0.09

General Comments

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