INT228401

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Context Info
Confidence 0.53
First Reported 2008
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 24
Total Number 24
Disease Relevance 6.46
Pain Relevance 1.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Cd86)
Anatomy Link Frequency
CD86 20
poly 1
B cells 1
T-cells 1
DEC-205 1
Cd86 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 181 99.32 Very High Very High Very High
Central nervous system 45 96.92 Very High Very High Very High
agonist 35 96.72 Very High Very High Very High
Arthritis 30 94.76 High High
cytokine 166 93.00 High High
Inflammation 167 92.60 High High
imagery 46 78.92 Quite High
spastic colon 3 73.12 Quite High
Inflammatory mediators 3 71.60 Quite High
Deep tissue 2 68.92 Quite High
Disease Link Frequency Relevance Heat
Infection 247 99.44 Very High Very High Very High
Rheumatoid Arthritis 181 99.32 Very High Very High Very High
Disease 235 95.12 Very High Very High Very High
Arthritis 30 94.76 High High
INFLAMMATION 187 92.60 High High
Candida Infection 138 92.40 High High
Pulmonary Disease 7 90.64 High High
Coronavirus Infection 84 90.08 High High
Severe Acute Respiratory Syndrome 114 89.92 High High
Neurocysticercosis 30 89.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CD86 levels also increased from 8.8% to 31.9% in control cultures (Fig. 5).
Positive_regulation (increased) of CD86 in CD86
1) Confidence 0.53 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998772 Disease Relevance 0 Pain Relevance 0
CD86 is upregulated on activated B cells upon B-cell receptor (BCR) and CD19/CD21 complex engagement [24,25].
Positive_regulation (upregulated) of CD86 in B cells
2) Confidence 0.52 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888223 Disease Relevance 0.82 Pain Relevance 0.30
PMA, which is known to cause B cell activation [36], resulted in the upregulation of CD40, CD86, and CD80 and the downregulation of MHC II.
Positive_regulation (upregulation) of CD86 in CD86
3) Confidence 0.51 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2871797 Disease Relevance 0.07 Pain Relevance 0.11
As for CD86, the evaluation of Fc?
Positive_regulation (evaluation) of CD86 in CD86
4) Confidence 0.38 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888223 Disease Relevance 0.75 Pain Relevance 0.29
RIIb is sufficient to induce an increase in the expression of CD86 [38,39], whereas the overexpression of this receptor on murine B cells reverses the induction of CD86 triggered via BCR [9].
Positive_regulation (induction) of CD86 in CD86
5) Confidence 0.38 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888223 Disease Relevance 0.80 Pain Relevance 0.25
It is possible that CD80 and CD86 have distinct functions, and that CD86 is induced later in the immune response than is CD80.
Positive_regulation (induced) of CD86 in CD86
6) Confidence 0.37 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2582810 Disease Relevance 0.22 Pain Relevance 0
There may have been a slight increase in CD86 levels (Fig. 5) in cultures pretreated with vitamin C.
Positive_regulation (increase) of CD86 in CD86
7) Confidence 0.35 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998772 Disease Relevance 0 Pain Relevance 0
Similarly, MA15 infection in vitro did not result in upregulation of CD86 on AM (Fig.
Positive_regulation (upregulation) of CD86 in CD86 associated with infection
8) Confidence 0.33 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2762542 Disease Relevance 1.43 Pain Relevance 0.10
Co-culture with AMs prevented CD86 and MHC class II, and to a lesser extent, CD40 upregulation (Fig. 4 C).
Positive_regulation (upregulation) of CD86 in CD86
9) Confidence 0.33 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2762542 Disease Relevance 0.28 Pain Relevance 0
After 24 h stimulation, poly I:C but not LPS treatment resulted in a pronounced upregulation of CD86 (Fig. 6 A).
Positive_regulation (upregulation) of CD86 in poly
10) Confidence 0.33 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2762542 Disease Relevance 0.13 Pain Relevance 0.08
Cells co-stained for both CD80 and CD86 showed an increase in the CD86 positive population from 16.7% ± 5.9% SEM with LPS alone to 34.8% ± 5.8% with LPS in the presence of SGE (P < 0.05) (Figure 1B).
Positive_regulation (population) of CD86 in CD86
11) Confidence 0.31 Published 2010 Journal Parasit Vectors Section Body Doc Link PMC2993695 Disease Relevance 0 Pain Relevance 0.09
Addition of the MEK inhibitor, PD98059, prior to SGE and LPS treatment, inhibited SGE induced CD86 up-regulation in this study.
Positive_regulation (induced) of CD86 in CD86
12) Confidence 0.31 Published 2010 Journal Parasit Vectors Section Body Doc Link PMC2993695 Disease Relevance 0.09 Pain Relevance 0.03
Inhibition of MEK prevents up-regulation of CD86
Positive_regulation (up-regulation) of CD86 in CD86
13) Confidence 0.29 Published 2010 Journal Parasit Vectors Section Body Doc Link PMC2993695 Disease Relevance 0 Pain Relevance 0.04
In contrast, CD80 and CD86 are inducible on DCs and other APCs upon stimulation.
Positive_regulation (inducible) of CD86 in CD86
14) Confidence 0.25 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2582810 Disease Relevance 0.11 Pain Relevance 0.12
In some experiments, BMDC were activated overnight with 1 µg/ml of LPS (mBMDC) and stained for CD86, CD40, or MHCII (IA/IE) expression.
Positive_regulation (stained) of CD86 in CD86
15) Confidence 0.25 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2658739 Disease Relevance 0 Pain Relevance 0.09
Significant upregulation of CD40, CD80 and CD86 was observed in JEV infected NSPCs at 3 dpi only compared to uninfected controls and JEV infected isotype controls (Fig. 2A i, ii, iii v, vi, vii) (p<0.05).
Positive_regulation (upregulation) of CD86 in CD86
16) Confidence 0.22 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2780913 Disease Relevance 0.19 Pain Relevance 0
The combination of this interaction further drives the upregulation of both CD80 and CD86 on the surface of APCs.
Positive_regulation (upregulation) of CD86 in CD86
17) Confidence 0.21 Published 2011 Journal Autoimmune Diseases Section Body Doc Link PMC3003960 Disease Relevance 0 Pain Relevance 0.09
For FACS analysis, the following monoclonal antibodies were used: I-A/I-E, CD80, CD86, CD11c, and DEC-205.
Positive_regulation (used) of CD86 in DEC-205
18) Confidence 0.20 Published 2009 Journal Respir Res Section Body Doc Link PMC2731726 Disease Relevance 0.40 Pain Relevance 0
Mature DCs (mDC) express high levels of co-stimulatory molecules CD40, CD80 and CD86, which synergize with antigen in the activation of naïve T-cells.
Positive_regulation (levels) of CD86 in T-cells
19) Confidence 0.20 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2776531 Disease Relevance 0 Pain Relevance 0
These results was consistent with the report from Anne Krug that CpG could promote survival of PDCs, activate purified PDCs by a rapid increase of CD80, CD86 and CD40 expression but the increased degree of CD80 was much lower than that of CD86 [37].
Positive_regulation (increase) of CD86 in CD86
20) Confidence 0.15 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793013 Disease Relevance 0.29 Pain Relevance 0

General Comments

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