INT228404

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Context Info
Confidence 0.35
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 12
Disease Relevance 7.18
Pain Relevance 1.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Slc12a3) transport (Slc12a3) plasma membrane (Slc12a3)
transmembrane transport (Slc12a3)
Anatomy Link Frequency
brain 2
embryos 1
cartilage 1
second branchial arch 1
mesodermal cells 1
Slc12a3 (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 99 98.88 Very High Very High Very High
substance P 57 94.08 High High
ischemia 2 89.36 High High
Hippocampus 4 88.00 High High
Pyramidal cell 4 87.24 High High
cytokine 30 85.52 High High
Inflammation 33 75.12 Quite High
Inflammatory mediators 2 71.60 Quite High
Inflammatory response 21 61.92 Quite High
midbrain 14 54.72 Quite High
Disease Link Frequency Relevance Heat
Neurocysticercosis 114 100.00 Very High Very High Very High
Disease 26 100.00 Very High Very High Very High
Apoptosis 133 99.92 Very High Very High Very High
Cyst 12 99.68 Very High Very High Very High
Targeted Disruption 231 99.22 Very High Very High Very High
Convulsion 7 99.08 Very High Very High Very High
Granuloma 94 99.00 Very High Very High Very High
Central Nervous System Disease 57 98.88 Very High Very High Very High
Syndrome 7 96.04 Very High Very High Very High
Craniosynostosis 7 95.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To gain insight into the role of Spry1 in development of NCC-derived structures, we used a floxed transgenic allele of Spry1 [21], and induced its expression in NCC by Cre-mediated recombination driven by the Wnt1 promoter [20].
Gene_expression (expression) of NCC associated with targeted disruption
1) Confidence 0.35 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2874773 Disease Relevance 0.42 Pain Relevance 0
Presumptive NCC marked by ?
Gene_expression (Presumptive) of NCC
2) Confidence 0.30 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2874773 Disease Relevance 0.26 Pain Relevance 0
Furthermore, NCC proliferate, migrate, and differentiate into cartilage and bone in vitro in response to FGF2 [5,6].
Gene_expression (proliferate) of NCC in cartilage
3) Confidence 0.30 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2874773 Disease Relevance 0.26 Pain Relevance 0
We conclude that Spry1 is a regulator of NCC cell proliferation and survival and that this occurs in both NCC cells and NCC-derived mesodermal cells that result in craniofacial and cardiac structures.


Gene_expression (occurs) of NCC in mesodermal cells
4) Confidence 0.30 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2874773 Disease Relevance 0.56 Pain Relevance 0.03
A hypomorphic allele of Fgfr1 has been used to demonstrate that FGFR1 is required for NCC migration into the second branchial arch [8].
Gene_expression (migration) of NCC in second branchial arch
5) Confidence 0.30 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2874773 Disease Relevance 0.26 Pain Relevance 0
While it is likely that increased proliferation and decreased apoptosis in NCC of Spry1;Wnt1-Cre embryos contributes to the phenotype, it is also possible that similar to the Pdgfr?
Gene_expression (embryos) of NCC in embryos associated with apoptosis
6) Confidence 0.30 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2874773 Disease Relevance 0.36 Pain Relevance 0
Presumptive NCC marked by ?
Gene_expression (marked) of NCC
7) Confidence 0.30 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2874773 Disease Relevance 0.21 Pain Relevance 0
In this report we studied the expression and distribution of TLRs 11–13 in the brain under normal physiological conditions and during murine NCC.
Gene_expression (expression) of NCC in brain associated with neurocysticercosis
8) Confidence 0.20 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2631477 Disease Relevance 1.17 Pain Relevance 0.28
Taken together, the constitutive expression of TLR12 in normal brain and its increased expression during NCC suggest a possible role in CNS function.


Gene_expression (expression) of NCC in brain associated with central nervous system and neurocysticercosis
9) Confidence 0.18 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2631477 Disease Relevance 0.27 Pain Relevance 0.14
Rather, we have previously demonstrated that early granuloma formed in response to dying cysts contributes to NCC disease manifestations by producing mediators that induce seizures [46].
Gene_expression (producing) of NCC associated with convulsion, cyst, disease, granuloma and neurocysticercosis
10) Confidence 0.14 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2817809 Disease Relevance 2.00 Pain Relevance 0.31
Consistent with this, the granulomatous response in human NCC has a strong immunoregulatory component involving the expression of IL-10 and TGF-?
Gene_expression (response) of NCC associated with neurocysticercosis
11) Confidence 0.06 Published 2008 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2274955 Disease Relevance 0.79 Pain Relevance 0.21
In the NCC samples analyzed, parasite-derived GCs were detected in numerous cells surrounding the parasites.
Gene_expression (detected) of NCC associated with neurocysticercosis
12) Confidence 0.05 Published 2008 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2274955 Disease Relevance 0.64 Pain Relevance 0.03

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