INT228409

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Context Info
Confidence 0.73
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.39
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (DSP) structural molecule activity (DSP) plasma membrane (DSP)
protein binding, bridging (DSP) cytoplasm (DSP)
Anatomy Link Frequency
IB4 2
cardiomyocytes 1
DSP (Homo sapiens)
Pain Link Frequency Relevance Heat
Central nervous system 35 59.12 Quite High
Pain 18 50.72 Quite High
peripheral neuropathy 1 50.00 Quite Low
Sciatica 1 21.52 Low Low
alcohol 1 20.36 Low Low
addiction 3 19.92 Low Low
reflex sympathetic dystrophy 1 18.12 Low Low
Inflammatory response 14 5.00 Very Low Very Low Very Low
Kinase C 13 5.00 Very Low Very Low Very Low
Inflammation 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 100 100.00 Very High Very High Very High
Neuropathy 58 100.00 Very High Very High Very High
Heart Defects 4 99.82 Very High Very High Very High
Arrhythmogenic Right Ventricular Dysplasia 3 99.16 Very High Very High Very High
Alopecia 2 95.76 Very High Very High Very High
Arrhythmia Under Development 1 94.56 High High
Adhesions 51 90.36 High High
Foot Deformities 1 88.80 High High
Peripheral Arterial Disease 1 69.12 Quite High
Disease 33 67.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, all defects of desmosomal components causing heart defects such as desmoplakin, plakoglobin, plakophilin 2, Dsg 2 and Dsc 2 lead to the phenotype of arrhythmogenic right ventricular cardiomyopathy (ARVC) which is clinically characterized by right bundle block and arrhythmia and histologically by fibrofatty replacement of cardiomyocytes, possibly due to impaired cell adhesion caused by loss and alterations of desmosomes (Asimaki et al. 2007; Gerull et al. 2004; McKoy et al. 2000; Pilichou et al. 2006; Rampazzo et al. 2002; Syrris et al. 2006; Heuser et al. 2006).
Localization (lead) of desmoplakin in cardiomyocytes associated with arrhythmia under development, heart defects, adhesions and arrhythmogenic right ventricular dysplasia
1) Confidence 0.73 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 1.30 Pain Relevance 0
pDSPs that are most likely to affect gene function include (i) those destroying conserved target sites (DC) and (ii) those creating illegitimate target sites (CNC) in ¬Ďanti-target¬í genes. pDSP causing DC events can be selected as such in the Patrocles database.
Localization (selected) of pDSP
2) Confidence 0.21 Published 2010 Journal Nucleic Acids Research Section Body Doc Link PMC2808989 Disease Relevance 0 Pain Relevance 0
Two scoring instruments of composite physical examinations were used as additional means of quantifying severity of DSP [22].
Localization (severity) of DSP associated with neuropathy
3) Confidence 0.16 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2940775 Disease Relevance 0.62 Pain Relevance 0.05
In contrast to IB4 bound material which is lost by 3 DPI, WGA bound material is constantly released by the parasite throughout the infection (Figures 4E (3 DPI) and 4F (3 WPI)), and it can be detected in infiltrates located far away from parasites (see below).


Localization (released) of DPI in IB4 associated with infection
4) Confidence 0.06 Published 2008 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2274955 Disease Relevance 0.23 Pain Relevance 0.03
In contrast to IB4 bound material which is lost by 3 DPI, WGA bound material is constantly released by the parasite throughout the infection (Figures 4E (3 DPI) and 4F (3 WPI)), and it can be detected in infiltrates located far away from parasites (see below).


Localization (released) of DPI in IB4 associated with infection
5) Confidence 0.06 Published 2008 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2274955 Disease Relevance 0.24 Pain Relevance 0.03

General Comments

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