INT228439

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Context Info
Confidence 0.01
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.28
Pain Relevance 0.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ntrk2) endosome (Ntrk2) aging (Ntrk2)
plasma membrane (Ntrk2)
Ntrk2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antidepressant 74 98.66 Very High Very High Very High
fluoxetine 8 96.40 Very High Very High Very High
Endep 6 88.48 High High
Hippocampus 8 71.64 Quite High
depression 10 48.04 Quite Low
Catecholamine 6 45.48 Quite Low
Neurotransmitter 4 5.00 Very Low Very Low Very Low
Dopamine 2 5.00 Very Low Very Low Very Low
Serotonin 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 2 78.16 Quite High
Depression 14 75.16 Quite High
Suicidal Behaviour 2 67.88 Quite High
Clinical Trials And Case Reports 2 5.00 Very Low Very Low Very Low
Affective Disorder 2 5.00 Very Low Very Low Very Low
Toxicity 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Reboxetine worked in an exactly opposite way on the transcription of growth factors, by strongly increasing down regulated factors and modestly reducing up regulated factors.
Positive_regulation (increasing) of Regulation (regulated) of factors
1) Confidence 0.01 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2275236 Disease Relevance 0.06 Pain Relevance 0.47
All four classes of antidepressants, tested in our study, antagonistically reversed strong up or down regulation of growth factors, induced by PMA in cultured SY5Y cells [15,20].
Positive_regulation (induced) of Regulation (regulation) of factors associated with antidepressant
2) Confidence 0.01 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2275236 Disease Relevance 0.22 Pain Relevance 0.29

General Comments

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