INT228443

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Context Info
Confidence 0.22
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.81
Pain Relevance 0.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ntrk2) endosome (Ntrk2) aging (Ntrk2)
plasma membrane (Ntrk2)
Anatomy Link Frequency
nerve 2
Ntrk2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 6 99.80 Very High Very High Very High
fluoxetine 4 96.40 Very High Very High Very High
Endep 3 88.48 High High
antidepressant 37 85.12 High High
Glutamate 5 80.48 Quite High
Neuronal excitability 1 78.00 Quite High
Neuropathic pain 18 59.44 Quite High
Spinal cord 27 57.20 Quite High
GABAergic 8 55.76 Quite High
antagonist 9 50.60 Quite High
Disease Link Frequency Relevance Heat
Pain 6 99.80 Very High Very High Very High
Nervous System Injury 4 99.48 Very High Very High Very High
Injury 12 88.84 High High
Nociception 7 85.40 High High
Spinal Cord Injury 72 60.00 Quite High
Neuropathic Pain 26 59.44 Quite High
Stress 1 56.56 Quite High
Contusions 4 39.56 Quite Low
Hyperalgesia 42 33.44 Quite Low
Depression 7 19.08 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Indeed, the intracellular signals activated by NMDA, such as ERK and Akt, are partially dependent on TrkB activation, as also observed for GSK3 signalling in the present study [30].
Regulation (dependent) of Positive_regulation (activation) of TrkB
1) Confidence 0.22 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2858808 Disease Relevance 0 Pain Relevance 0.04
A recent report shows that this transient down-regulation of KCC2 [22] and the early pain behavior depends on activation of TrkB receptor via BDNF in nerve injury [12].
Regulation (depends) of Positive_regulation (activation) of TrkB receptor in nerve associated with pain and nervous system injury
2) Confidence 0.01 Published 2008 Journal Mol Pain Section Body Doc Link PMC2561007 Disease Relevance 0.75 Pain Relevance 0.33
Reboxetine worked in an exactly opposite way on the transcription of growth factors, by strongly increasing down regulated factors and modestly reducing up regulated factors.
Regulation (regulated) of Positive_regulation (increasing) of factors
3) Confidence 0.00 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2275236 Disease Relevance 0.06 Pain Relevance 0.47

General Comments

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