INT228445

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Context Info
Confidence 0.03
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 0.35
Pain Relevance 1.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Mtpn) nucleus (Mtpn) cytoplasm (Mtpn)
Mtpn (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antidepressant 185 99.72 Very High Very High Very High
Endep 15 96.00 Very High Very High Very High
depression 25 91.68 High High
fluoxetine 20 90.72 High High
Hippocampus 20 85.92 High High
Neurotransmitter 10 69.44 Quite High
Dopamine 5 29.00 Quite Low
Serotonin 5 28.48 Quite Low
Catecholamine 15 24.92 Low Low
Disease Link Frequency Relevance Heat
Clinical Trials And Case Reports 5 93.24 High High
Depression 35 91.68 High High
Stress 5 86.32 High High
Suicidal Behaviour 5 41.56 Quite Low
Affective Disorder 5 22.24 Low Low
Toxicity 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These and our observations assign a role of modulators to antidepressants, rather than pure stimulators of growth factor transcription.
Transcription (transcription) of growth factor associated with antidepressant
1) Confidence 0.03 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2275236 Disease Relevance 0.09 Pain Relevance 0.37
The general common observation was that all four antidepressant drugs counteracted alterations of growth factor transcription, induced by PMA.
Transcription (transcription) of growth factor associated with antidepressant
2) Confidence 0.03 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2275236 Disease Relevance 0 Pain Relevance 0.32
The effects of magnetic stimulation and antidepressants on different growth factor transcription were analysed by rtPCR and were summarized in figure 2.
Transcription (transcription) of growth factor associated with antidepressant
3) Confidence 0.03 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2275236 Disease Relevance 0.07 Pain Relevance 0.35
This study focuses mainly on the analysis of growth factor transcription by real time PCR analysis in a cell culture system, after administration of antidepressant drugs.
Transcription (transcription) of growth factor associated with antidepressant
4) Confidence 0.03 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2275236 Disease Relevance 0.18 Pain Relevance 0.34
We conclude from our experiments that antidepressant drugs rather modulate PMA-induced changes of growth factor transcription, than induce an overall transcription increase.
Transcription (transcription) of growth factor associated with antidepressant
5) Confidence 0.02 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2275236 Disease Relevance 0 Pain Relevance 0.34

General Comments

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