INT228447

Context Info Confidence 0.00 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.07 Pain Relevance 0.49

cytosol (PMAIP1, Cntf) nucleus (PMAIP1, Cntf) cell differentiation (Cntf) extracellular space (Cntf) mitochondrion (PMAIP1) growth (Cntf)

PMAIP1 (Homo sapiens) Cntf (Rattus norvegicus)

Pain Link Frequency Relevance Heat Endep 3 99.54 antidepressant 37 95.72 fluoxetine 4 76.48 Hippocampus 4 26.16 depression 5 5.00 Catecholamine 3 5.00 Neurotransmitter 2 5.00 Dopamine 1 5.00 Serotonin 1 5.00

Disease Link Frequency Relevance Heat Stress 1 67.16 Depression 7 29.68 Suicidal Behaviour 1 22.40 Clinical Trials And Case Reports 1 5.00 Affective Disorder 1 5.00 Toxicity 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Amitriptyline, for example, did not prevent the PMA-induced decrease of bFGF and CNTF, but it worked antagonistically for all other factors.

Negative_regulation (prevent) of PMA-induced Negative_regulation (decrease) of CNTF associated with endep

1) Confidence 0.00 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2275236 Disease Relevance 0.07 Pain Relevance 0.49

General Comments

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