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Context Info
Confidence 0.12
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.17
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Prkca) endoplasmic reticulum (Prkca) enzyme binding (Prkca)
protein complex (Prkca) cytoplasm (Prkca) cytosol (Prkca)
Igf1 (Mus musculus)
Prkca (Mus musculus)
Pain Link Frequency Relevance Heat
Hyperalgesia 14 63.36 Quite High
dorsal root ganglion 42 56.12 Quite High
Pain 22 50.00 Quite Low
Spinal cord 6 35.24 Quite Low
Deafferentation 1 23.52 Low Low
agonist 2 18.56 Low Low
diabetic neuropathy 17 5.00 Very Low Very Low Very Low
hypoalgesia 14 5.00 Very Low Very Low Very Low
qutenza 10 5.00 Very Low Very Low Very Low
isoflurane 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 118 98.36 Very High Very High Very High
Hyperglycemia 8 90.36 High High
Hyperalgesia 48 80.96 Quite High
Hypoxia 2 65.56 Quite High
Retinal Neovascularization 3 63.96 Quite High
Targeted Disruption 37 59.44 Quite High
Ganglion Cysts 42 56.12 Quite High
Pain 21 50.00 Quite Low
Neuropathic Pain 8 49.36 Quite Low
Stress 1 17.68 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
VEGF induction by IGF-1 occurs via different signaling pathways including PKC (22) and PI3-K (23–25).
IGF-1 Positive_regulation (induction) of PKC
1) Confidence 0.12 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2820781 Disease Relevance 0.19 Pain Relevance 0
Previously, we showed that insulin and IGF-1, acting via the IGF-1 receptor, potentiates TRPV1 current by activating PKC [50].
IGF-1 Positive_regulation (activating) of PKC
2) Confidence 0.09 Published 2008 Journal Mol Pain Section Body Doc Link PMC2275252 Disease Relevance 0.98 Pain Relevance 0.12

General Comments

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