INT228457

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Context Info
Confidence 0.05
First Reported 2008
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.01
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Trpv1) carbohydrate metabolic process (Ins1) transmembrane transport (Trpv1)
lipid metabolic process (Trpv1) cytoplasm (Ins1) cytosol (Trpv1)
Ins1 (Mus musculus)
Trpv1 (Mus musculus)
Pain Link Frequency Relevance Heat
Hyperalgesia 14 99.44 Very High Very High Very High
Deafferentation 1 59.04 Quite High
Pain 22 50.00 Quite Low
dorsal root ganglion 42 39.76 Quite Low
Spinal cord 6 18.88 Low Low
diabetic neuropathy 17 5.00 Very Low Very Low Very Low
hypoalgesia 14 5.00 Very Low Very Low Very Low
qutenza 10 5.00 Very Low Very Low Very Low
Dopamine 3 5.00 Very Low Very Low Very Low
Thermal hyperalgesia 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperalgesia 48 99.44 Very High Very High Very High
Diabetes Mellitus 118 96.24 Very High Very High Very High
Targeted Disruption 36 94.96 High High
Neuropathic Pain 8 84.88 Quite High
Hyperglycemia 8 74.00 Quite High
Stress 1 53.20 Quite High
Pain 21 50.00 Quite Low
Ganglion Cysts 42 39.76 Quite Low
Death 1 37.92 Quite Low
Peripheral Neuropathy 17 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is possible that an abrupt reduction in insulin levels as occurs in STZ-treated mice could trigger compensatory enhancement of TRPV1 expression resulting in hyperalgesia.
Spec (37321) Negative_regulation (reduction) of insulin Positive_regulation (trigger) of Gene_expression (expression) of TRPV1 associated with hyperalgesia
1) Confidence 0.05 Published 2008 Journal Mol Pain Section Body Doc Link PMC2275252 Disease Relevance 1.01 Pain Relevance 0.21

General Comments

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