INT228465

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.64
First Reported 2007
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 4
Total Number 7
Disease Relevance 6.29
Pain Relevance 3.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Timp2) nucleus (Timp2)
Anatomy Link Frequency
paw 1
extracellular matrix 1
astrocytes 1
Timp2 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 89 99.88 Very High Very High Very High
palliative 172 99.78 Very High Very High Very High
antagonist 11 95.68 Very High Very High Very High
Arthritis 108 95.64 Very High Very High Very High
Kinase C 1 95.12 Very High Very High Very High
Inflammation 49 76.00 Quite High
rheumatoid arthritis 54 66.96 Quite High
cytokine 36 61.76 Quite High
ischemia 1 28.24 Quite Low
chemokine 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Metastasis 105 99.52 Very High Very High Very High
Hepatocellular Cancer 232 99.30 Very High Very High Very High
Lung Cancer 136 99.08 Very High Very High Very High
Synovitis 3 96.68 Very High Very High Very High
Arthritis 112 95.64 Very High Very High Very High
Malignant Neoplastic Disease 13 94.28 High High
Osteogenic Sarcomas 1 90.92 High High
Cancer 204 90.64 High High
Diabetes Mellitus 1 89.76 High High
Lifespan 32 89.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Lower TIMP2 levels might cause MMP2 activation, which resulted in degradation of the extracellular matrix and increased angiogenesis.
Spec (might) Positive_regulation (activation) of TIMP2 in extracellular matrix
1) Confidence 0.64 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2976755 Disease Relevance 1.05 Pain Relevance 0.57
Our data revealed that palliative resection activated MMP2 and down-regulated TIMP2.
Positive_regulation (activated) of TIMP2 associated with palliative
2) Confidence 0.64 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2976755 Disease Relevance 1.05 Pain Relevance 0.58
Palliative resection-stimulated HCC metastasis may occur, in part, by up-regulation of VEGF and MMP2/TIMP2.
Positive_regulation (up-regulation) of TIMP2 associated with hepatocellular cancer, metastasis and palliative
3) Confidence 0.43 Published 2010 Journal BMC Cancer Section Abstract Doc Link PMC2976755 Disease Relevance 0.51 Pain Relevance 0.43
This study showed that palliative resection-accelerated HCC metastasis may be attributed, in part, to up-regulation of VEGF and MMP2/TIMP2; SYY reinforced IFN-?
Positive_regulation (up-regulation) of TIMP2 associated with hepatocellular cancer, metastasis and palliative
4) Confidence 0.43 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2976755 Disease Relevance 1.01 Pain Relevance 0.29
in the paw and an increased TIMP2:MMP2 ratio [29].
Positive_regulation (increased) of TIMP2 in paw
5) Confidence 0.26 Published 2008 Journal Mod Rheumatol Section Body Doc Link PMC2275302 Disease Relevance 1.28 Pain Relevance 0.58
In ET-1-activated human optic nerve head astrocytes, levels of MMP-1, TIMP-1, and TIMP-2 are all increased.
Positive_regulation (increased) of TIMP-2 in astrocytes
6) Confidence 0.17 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2913859 Disease Relevance 0.54 Pain Relevance 0.20
Our group recently found expression of MMP-2, MMP-9, MMP-14 (MT1-MMP) and TIMP-2 and activation of MMP-2 and MMP-9 in MM effusions (Sivertsen, 2006).
Positive_regulation (activation) of TIMP-2 associated with lung cancer and metalloproteinase
7) Confidence 0.03 Published 2007 Journal Biomarker Insights Section Body Doc Link PMC2717840 Disease Relevance 0.86 Pain Relevance 0.90

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox