INT228469

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Context Info
Confidence 0.54
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 19
Total Number 19
Disease Relevance 18.76
Pain Relevance 6.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il17a) extracellular region (Il17a)
Anatomy Link Frequency
Th17 cell 3
blood 1
lymphocyte 1
lungs 1
memory T cells 1
Il17a (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 266 100.00 Very High Very High Very High
Etanercept 27 99.98 Very High Very High Very High
Arthritis 499 99.80 Very High Very High Very High
cytokine 436 99.20 Very High Very High Very High
dexamethasone 48 98.76 Very High Very High Very High
antagonist 12 97.30 Very High Very High Very High
Multiple sclerosis 101 97.20 Very High Very High Very High
rheumatoid arthritis 434 96.44 Very High Very High Very High
addiction 1 94.84 High High
psoriasis 101 89.60 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 283 100.00 Very High Very High Very High
Cancer 33 100.00 Very High Very High Very High
Necrosis 24 100.00 Very High Very High Very High
Repression 4 100.00 Very High Very High Very High
Infection 530 99.96 Very High Very High Very High
Arthritis 432 99.80 Very High Very High Very High
Sprains And Strains 329 99.76 Very High Very High Very High
Disease 470 99.28 Very High Very High Very High
Experimental Arthritis 22 98.60 Very High Very High Very High
Death 101 98.10 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The depletion of IL-17A also exacerbated disease manifestations, evident mainly following infection with 30 CFU (Figure 10).
Negative_regulation (depletion) of IL-17A associated with disease and infection
1) Confidence 0.54 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2887844 Disease Relevance 0.96 Pain Relevance 0.17
In vivo depletion of IL-17A with an antibody impaired bacterial clearance from the lungs [34].
Negative_regulation (depletion) of IL-17A in lungs
2) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2887844 Disease Relevance 0.99 Pain Relevance 0.14
In this experimental setup, the effect of IL-17A depletion on morbidity was clearly manifested.
Negative_regulation (depletion) of IL-17A
3) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2887844 Disease Relevance 1.01 Pain Relevance 0
In order to directly test the in vivo role of IL-17A in the response to sub-lethal LVS infection, IL-17A was depleted in vivo using anti-IL17A antibodies.
Negative_regulation (depleted) of IL-17A associated with sprains and strains and infection
4) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2887844 Disease Relevance 0.99 Pain Relevance 0.07
Whether regulating Th17 cell activity or specific combinations of Th17 cytokines will have additional value compared to neutralizing IL-17A activity alone or TNF alone needs to be elucidated.
Negative_regulation (neutralizing) of IL-17A in Th17 cell associated with cytokine
5) Confidence 0.34 Published 2010 Journal Semin Immunopathol Section Body Doc Link PMC2836464 Disease Relevance 1.14 Pain Relevance 0.62
Interestingly, 1,25-(OH)2D3, in contrast to dexamethasone, directly modulated human Th17 polarization accompanied with suppression of IL-17A, IL-17F, TNF-alpha, and IL-22 production by FACS sorted memory T cells from these early RA patients [14].


Negative_regulation (suppression) of IL-17A in memory T cells associated with rheumatoid arthritis and dexamethasone
6) Confidence 0.34 Published 2010 Journal Semin Immunopathol Section Body Doc Link PMC2836464 Disease Relevance 1.09 Pain Relevance 0.63
In contrast, IL-17 was induced shortly after initiation and declined in time [9].
Negative_regulation (declined) of IL-17
7) Confidence 0.34 Published 2010 Journal Semin Immunopathol Section Body Doc Link PMC2836464 Disease Relevance 0.98 Pain Relevance 0.39
The observed increase in expression levels of IL17A, IL17F, IL22 and IL26 and the downstream proinflammatory cytokines IL6 and IL1?
Negative_regulation (levels) of IL17A associated with cytokine
8) Confidence 0.30 Published 2010 Journal BMC Immunol Section Body Doc Link PMC3016394 Disease Relevance 0.89 Pain Relevance 0.43
Both SHED and BMMSC transplantations showed no significant changes in the level of IL10 and IL6 in MRL/lpr mice (Figures 5D and 5E); however, SHED transplantation provided a remarkable reduction of TH17 cells and IL17 level in MRL/lpr mice when compared to BMMSC transplantation (Figures 5C and 5F).
Negative_regulation (reduction) of IL17
9) Confidence 0.27 Published 2010 Journal Stem Cell Res Ther Section Body Doc Link PMC2873699 Disease Relevance 0.66 Pain Relevance 0.11
is an important negative regulator, not only of IL-17 but also of IFN?
Negative_regulation (regulator) of IL-17
10) Confidence 0.16 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2571924 Disease Relevance 0.77 Pain Relevance 0.43
In contrast, IL-17 levels in cultures from CpdA treated mice were significantly reduced after restimulation with MOG35–55, which was not the case after polyclonal stimulation with ConA (Fig. 6D).
Negative_regulation (reduced) of IL-17
11) Confidence 0.16 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2781169 Disease Relevance 0.94 Pain Relevance 0.27
In particular lymphocyte death, a bona fide example of GR transactivation, is not induced at these CpdA concentrations while repression of IL-17, LFA-1 and CD-44 efficiently occurs.
Negative_regulation (repression) of IL-17 in lymphocyte associated with repression and death
12) Confidence 0.16 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2781169 Disease Relevance 1.21 Pain Relevance 0.16
production was significantly increased as reflected by a decreased IL-17/IFN-?
Negative_regulation (decreased) of IL-17
13) Confidence 0.14 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2658739 Disease Relevance 0 Pain Relevance 0.08
The expression level of miR-146a and IL-17 in patient RA1 and RA4 was high in comparison to the other patients. miR-146a expressed intensely with IL-17 expression in PBMC from the patients with early stage of RA and high disease activity (Figure 2B).


Negative_regulation (level) of IL-17 associated with rheumatoid arthritis and disease
14) Confidence 0.13 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2950393 Disease Relevance 1.60 Pain Relevance 0.74
Apart from the increase of IL-10 serum levels, reduced levels of interferon, tumour necrosis factor-alpha, and IL-17 from stimulated T cells of mice with chronic inflammatory arthritis were described after allogeneic HSCT [17].
Negative_regulation (reduced) of IL-17 in T cells associated with necrosis, inflammation, cancer and arthritis
15) Confidence 0.12 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592775 Disease Relevance 0.90 Pain Relevance 0.18
Using in situ hybridization, Matusevicius et al.demonstrated higher numbers of IL-17 mRNA-positive mononuclear cells (MNCs) in peripheral blood of 40% of MS patients compared with healthy controls [83].
Negative_regulation (numbers) of IL-17 in blood associated with multiple sclerosis
16) Confidence 0.08 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2768824 Disease Relevance 1.44 Pain Relevance 0.47
Thus it is possible that CP-690550, through inhibition of IL-21R signaling, may also be efficacious in the CIA model by reducing IL-17 producing Th17 cells which have been proposed to play an important role in the pathogenesis of autoimmune diseases.
Negative_regulation (reducing) of IL-17 in Th17 cells associated with autoimmune disease and arthritis
17) Confidence 0.08 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374467 Disease Relevance 0.90 Pain Relevance 0.37
IL-17, IL-12, cathepsin K and osteoprotegrin ligand mRNA levels were also reduced [86, 87].
Negative_regulation (reduced) of IL-17
18) Confidence 0.04 Published 2008 Journal Mod Rheumatol Section Body Doc Link PMC2275302 Disease Relevance 1.29 Pain Relevance 0.62
antagonist therapy may be similar to the mechanism of ustekinumab by down-regulating pro-inflammatory pathways in lesional skin.25,26 Etanercept reduced the inflammatory dendritic cell products that drive Th17 cell proliferation (IL-23), as well as Th17 cell products and downstream effector molecules (IL-17, IL-22, CCL 20, and beta-defensin 4).
Negative_regulation (reduced) of IL-17 in Th17 cell associated with inflammation, antagonist and etanercept
19) Confidence 0.03 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2857612 Disease Relevance 1.01 Pain Relevance 0.57

General Comments

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