INT228474

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Context Info
Confidence 0.44
First Reported 2008
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 3.81
Pain Relevance 0.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Tnfsf10)
Tnfsf10 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 119 99.84 Very High Very High Very High
Arthritis 172 92.96 High High
Inflammation 91 83.48 Quite High
agonist 2 64.16 Quite High
cytokine 51 18.60 Low Low
metalloproteinase 10 5.00 Very Low Very Low Very Low
chemokine 8 5.00 Very Low Very Low Very Low
methotrexate 6 5.00 Very Low Very Low Very Low
Inflammatory response 5 5.00 Very Low Very Low Very Low
Angina 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 119 99.84 Very High Very High Very High
Myocardial Infarction 106 99.12 Very High Very High Very High
Death 28 98.84 Very High Very High Very High
Apoptosis 66 98.28 Very High Very High Very High
Arthritis 174 92.96 High High
INFLAMMATION 67 84.20 Quite High
Cv General 2 Under Development 2 71.44 Quite High
Rupture 2 70.16 Quite High
Experimental Arthritis 2 68.80 Quite High
Severe Combined Immunodeficiency 8 67.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found an inverse correlation between the serum levels of TRAIL, measured within 24 hours after admission, and both CK (R?
Regulation (correlation) of Gene_expression (levels) of TRAIL
1) Confidence 0.44 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2637972 Disease Relevance 0.57 Pain Relevance 0
Decreased TRAIL serum levels represent a negative prognostic factor at 12 months of follow-up in both univariable and multivariable analyses
Spec (analyses) Regulation (represent) of Gene_expression (levels) of TRAIL
2) Confidence 0.44 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2637972 Disease Relevance 0.62 Pain Relevance 0
Thus, the results of this study suggested that modulation of TRAIL-R expression could enable RA synoviocytes to be sensitized to TRAIL-mediated signaling.
Regulation (modulation) of Gene_expression (expression) of TRAIL-R associated with rheumatoid arthritis
3) Confidence 0.19 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2842969 Disease Relevance 1.13 Pain Relevance 0.30
Modulation of TRAIL receptor expression on RA synoviocytes has also been suggested as a gene therapy strategy for the treatment of RA [104].
Regulation (Modulation) of Gene_expression (expression) of TRAIL associated with rheumatoid arthritis
4) Confidence 0.03 Published 2008 Journal Mod Rheumatol Section Body Doc Link PMC2275302 Disease Relevance 1.49 Pain Relevance 0.44

General Comments

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