INT228476

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Context Info
Confidence 0.36
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 7
Disease Relevance 3.03
Pain Relevance 0.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Ctla4) plasma membrane (Ctla4)
Anatomy Link Frequency
T cell 5
CD86 1
Ctla4 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 72 99.32 Very High Very High Very High
Arthritis 109 99.12 Very High Very High Very High
cytokine 64 86.28 High High
Inflammation 86 85.92 High High
Kinase C 6 61.24 Quite High
chemokine 15 39.04 Quite Low
Pain 13 39.00 Quite Low
metalloproteinase 7 5.00 Very Low Very Low Very Low
cINOD 3 5.00 Very Low Very Low Very Low
tolerance 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 72 99.32 Very High Very High Very High
Arthritis 113 99.12 Very High Very High Very High
Infection 84 98.72 Very High Very High Very High
Mixed Connective Tissue Disorder 56 93.80 High High
Viral Infection 17 92.16 High High
Adhesions 2 90.40 High High
INFLAMMATION 89 85.92 High High
Apoptosis 15 85.88 High High
Autoimmune Disease 22 83.12 Quite High
Influenza Virus Infection 53 58.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
0.0001), accessory molecules (CD4, CD80, CD86, CD28 and CD152; P?
CD152 Binding (0.0001) of in CD86
1) Confidence 0.36 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2654967 Disease Relevance 0.22 Pain Relevance 0
Likewise, CD69, CD71, as markers for T cell activation, as well as CD152 (CTLA-4) were found to be expressed only at low levels, and with no difference between patients and controls.
CD152 Binding (markers) of in T cell
2) Confidence 0.28 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2912311 Disease Relevance 0.37 Pain Relevance 0
Likewise, CD69, CD71, as markers for T cell activation, as well as CD152 (CTLA-4) were found to be expressed only at low levels, and with no difference between patients and controls.
CTLA-4 Binding (markers) of in T cell
3) Confidence 0.28 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2912311 Disease Relevance 0.37 Pain Relevance 0
Likewise, CD69, CD71, as markers for T cell activation, as well as CD152 (CTLA-4) were found to be expressed only at low levels, and with no difference between patients and controls.
CTLA-4 Binding (found) of in T cell
4) Confidence 0.28 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2912311 Disease Relevance 0.37 Pain Relevance 0
Likewise, CD69, CD71, as markers for T cell activation, as well as CD152 (CTLA-4) were found to be expressed only at low levels, and with no difference between patients and controls.
CD152 Binding (found) of in T cell
5) Confidence 0.28 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2912311 Disease Relevance 0.37 Pain Relevance 0
How does this appreciation of CD28-mediated co-stimulation help us to understand the action of CTLA4-Ig treatment in RA?
CTLA4 Binding (action) of associated with rheumatoid arthritis
6) Confidence 0.19 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2582810 Disease Relevance 0.30 Pain Relevance 0.11
CTLA-4Ig fusion protein binds to the co-stimulatory molecules B7-1 and B7-2 present on antigen-presenting cells and blocks CD28/B7 interactions, resulting in decreased T cell activation.
CTLA-4Ig Binding (binds) of in T cell
7) Confidence 0.08 Published 2008 Journal Mod Rheumatol Section Body Doc Link PMC2275302 Disease Relevance 1.03 Pain Relevance 0.52

General Comments

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