INT228477

Context Info Confidence 0.11 First Reported 2008 Last Reported 2011 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 1.30 Pain Relevance 0.29

nucleoplasm (Cdkn2a) aging (Cdkn2a) DNA binding (Cdkn2a) protein complex (Cdkn2a) cytoplasm (Cdkn2a) nucleolus (Cdkn2a)

Cdkn2a (Mus musculus)

Pain Link Frequency Relevance Heat Arthritis 108 98.40 rheumatoid arthritis 54 87.84 cytokine 28 53.24 Inflammation 41 52.84 Inflammatory response 2 45.44 metalloproteinase 7 18.80 depression 4 5.00 chemokine 4 5.00 antagonist 2 5.00 methotrexate 2 5.00

Disease Link Frequency Relevance Heat Cancer 28 100.00 Arthritis 112 98.40 Apoptosis 17 97.20 Rheumatoid Arthritis 54 87.84 Lymphatic System Cancer 19 83.68 Pressure And Volume Under Development 6 78.68 Experimental Arthritis 1 70.80 INFLAMMATION 42 52.84 Hematologic Neoplasms 9 50.00 Death 6 49.52

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

It has been shown that HDACs inhibitors can selectively induce the expression of less than 10% of genes, some of which are involved in the inhibition of tumor growth (e.g., p21WAF1, p27Kip and p16ink4a) [19, 26, 38].

Positive_regulation (induce) of Gene_expression (expression) of p16ink4a associated with cancer

1) Confidence 0.11 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3004414 Disease Relevance 0.51 Pain Relevance 0

Other molecules that have been demonstrated to play a role in arthritis using gene transfer in various in vitro or animal models are Csk, cathepsin L, fibronectin, galectin-1, p16INK4A, p21Cip1, SOCS3, soluble CR1, superoxide dismutase and catalase, Ras, and prothymosin ?

Positive_regulation (soluble) of Gene_expression (fibronectin) of p16INK4A associated with arthritis

2) Confidence 0.09 Published 2008 Journal Mod Rheumatol Section Body Doc Link PMC2275302 Disease Relevance 0.78 Pain Relevance 0.29

General Comments

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