INT228477

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Context Info
Confidence 0.11
First Reported 2008
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.30
Pain Relevance 0.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Cdkn2a) aging (Cdkn2a) DNA binding (Cdkn2a)
protein complex (Cdkn2a) cytoplasm (Cdkn2a) nucleolus (Cdkn2a)
Cdkn2a (Mus musculus)
Pain Link Frequency Relevance Heat
Arthritis 108 98.40 Very High Very High Very High
rheumatoid arthritis 54 87.84 High High
cytokine 28 53.24 Quite High
Inflammation 41 52.84 Quite High
Inflammatory response 2 45.44 Quite Low
metalloproteinase 7 18.80 Low Low
depression 4 5.00 Very Low Very Low Very Low
chemokine 4 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
methotrexate 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 28 100.00 Very High Very High Very High
Arthritis 112 98.40 Very High Very High Very High
Apoptosis 17 97.20 Very High Very High Very High
Rheumatoid Arthritis 54 87.84 High High
Lymphatic System Cancer 19 83.68 Quite High
Pressure And Volume Under Development 6 78.68 Quite High
Experimental Arthritis 1 70.80 Quite High
INFLAMMATION 42 52.84 Quite High
Hematologic Neoplasms 9 50.00 Quite Low
Death 6 49.52 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It has been shown that HDACs inhibitors can selectively induce the expression of less than 10% of genes, some of which are involved in the inhibition of tumor growth (e.g., p21WAF1, p27Kip and p16ink4a) [19, 26, 38].
Positive_regulation (induce) of Gene_expression (expression) of p16ink4a associated with cancer
1) Confidence 0.11 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3004414 Disease Relevance 0.51 Pain Relevance 0
Other molecules that have been demonstrated to play a role in arthritis using gene transfer in various in vitro or animal models are Csk, cathepsin L, fibronectin, galectin-1, p16INK4A, p21Cip1, SOCS3, soluble CR1, superoxide dismutase and catalase, Ras, and prothymosin ?
Positive_regulation (soluble) of Gene_expression (fibronectin) of p16INK4A associated with arthritis
2) Confidence 0.09 Published 2008 Journal Mod Rheumatol Section Body Doc Link PMC2275302 Disease Relevance 0.78 Pain Relevance 0.29

General Comments

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