INT228540

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Context Info
Confidence 0.63
First Reported 2007
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 3.50
Pain Relevance 0.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (Coq10a) cellular_component (Coq10a) biological_process (Coq10a)
Anatomy Link Frequency
fibroblast 1
limb 1
Coq10a (Mus musculus)
Pain Link Frequency Relevance Heat
Substantia nigra 10 95.44 Very High Very High Very High
Demyelination 2 77.12 Quite High
Pain 8 75.96 Quite High
Hippocampus 9 53.72 Quite High
cerebral cortex 12 35.84 Quite Low
ketamine 1 5.20 Low Low
Inflammation 10 5.00 Very Low Very Low Very Low
sodium channel 6 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
Bioavailability 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperlipidemia 4 98.32 Very High Very High Very High
Immunization 4 97.12 Very High Very High Very High
Neuroblastoma 7 96.00 Very High Very High Very High
Apoptosis 31 95.52 Very High Very High Very High
Neuropathy 26 95.44 Very High Very High Very High
Death 42 94.64 High High
Vibrio Infection 9 93.16 High High
Ataxia 19 92.16 High High
Syndrome 36 91.68 High High
Hypertension 3 85.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Of note, this subgroup had significantly lower baseline serum CoQ10 levels.31
Localization (baseline) of CoQ10
1) Confidence 0.63 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2785862 Disease Relevance 0.74 Pain Relevance 0
In NSCs treated with GM1 and/or A?
Localization (treated) of GM1
2) Confidence 0.61 Published 2010 Journal ASN NEURO Section Body Doc Link PMC2838405 Disease Relevance 0.10 Pain Relevance 0.03
In NECs treated with GM1 and/or A?
Localization (treated) of GM1
3) Confidence 0.61 Published 2010 Journal ASN NEURO Section Body Doc Link PMC2838405 Disease Relevance 0 Pain Relevance 0
The number of cells cultured in the presence or absence of GM1 and/or A?
Localization (presence) of GM1
4) Confidence 0.61 Published 2010 Journal ASN NEURO Section Body Doc Link PMC2838405 Disease Relevance 0.08 Pain Relevance 0.08
The RasĀ–MAPK (mitogen-activated protein kinase) pathway, important for cell proliferation, was intact in NECs simultaneously treated with GM1 and A?
Localization (treated) of GM1
5) Confidence 0.61 Published 2010 Journal ASN NEURO Section Abstract Doc Link PMC2838405 Disease Relevance 0.47 Pain Relevance 0
As well, in NECs treated with GM1 and/or A?
Localization (treated) of GM1
6) Confidence 0.61 Published 2010 Journal ASN NEURO Section Body Doc Link PMC2838405 Disease Relevance 0.62 Pain Relevance 0.05
In the NECs simultaneously treated with GM1 and A?
Localization (treated) of GM1
7) Confidence 0.61 Published 2010 Journal ASN NEURO Section Body Doc Link PMC2838405 Disease Relevance 0 Pain Relevance 0
Decreased CoQ10 might be thus a serious problem, as most hypercholesterolemia patients who take statins are elderly.
Localization (Decreased) of CoQ10 associated with hyperlipidemia
8) Confidence 0.60 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2275764 Disease Relevance 0.10 Pain Relevance 0
Simvastatin also decreased both reduced and oxidized forms of CoQ9 and CoQ10.
Localization (forms) of CoQ10
9) Confidence 0.56 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2275764 Disease Relevance 0.14 Pain Relevance 0.05
, it is routinely employed either as a stain to visualize the subcellular localization of GM1, or as an extracellular ligand to visualize GM1 endocytosis events and vesicular trafficking [45].
Localization (localization) of GM1
10) Confidence 0.46 Published 2008 Journal Neurochem Res Section Body Doc Link PMC2758381 Disease Relevance 0.19 Pain Relevance 0
cells/mL were cultured in serum-free complete growth medium 1 (GM1) in the presence of epidermal growth factor and basic fibroblast growth factor (both 10?
Localization (presence) of GM1 in fibroblast
11) Confidence 0.28 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2821778 Disease Relevance 0 Pain Relevance 0.03
On sensitization with this GM1-like LOS, rabbits developed IgG anti-GM1 antibodies and subsequent flaccid limb weakness (Figure 2).
Localization (sensitization) of GM1 in limb
12) Confidence 0.04 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3010740 Disease Relevance 1.07 Pain Relevance 0.07

General Comments

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