INT228545

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Context Info
Confidence 0.42
First Reported 2007
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 5.62
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (Coq10a) cellular_component (Coq10a) biological_process (Coq10a)
Anatomy Link Frequency
respiratory 3
nodes 1
brain 1
Coq10a (Mus musculus)
Pain Link Frequency Relevance Heat
sodium channel 6 99.96 Very High Very High Very High
cerebral cortex 14 89.92 High High
Peripheral nerve injury 1 54.16 Quite High
projection neuron 4 47.88 Quite Low
Dopamine 12 24.32 Low Low
Substantia nigra 18 5.00 Very Low Very Low Very Low
Bioavailability 16 5.00 Very Low Very Low Very Low
Inflammation 11 5.00 Very Low Very Low Very Low
Central nervous system 8 5.00 Very Low Very Low Very Low
headache 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neurodegenerative Disease 112 100.00 Very High Very High Very High
Neuropathy 26 93.12 High High
Disease 233 92.40 High High
Parkinson's Disease 53 91.56 High High
Death 33 90.84 High High
Autoimmune Disease 8 84.72 Quite High
Ataxia 76 83.04 Quite High
Syndrome 37 82.12 Quite High
Stress 48 81.84 Quite High
Toxicity 16 79.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These studies to understand the roles of GM1 and A?
Regulation (roles) of GM1
1) Confidence 0.42 Published 2010 Journal ASN NEURO Section Body Doc Link PMC2838405 Disease Relevance 0.25 Pain Relevance 0
In healthy animals, oral administration of CoQ10 increases CoQ10 levels in the brain of older animals, whereas there is no effect on CoQ10 levels in young animals.
Neg (no) Regulation (effect) of CoQ10 in brain
2) Confidence 0.38 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2785862 Disease Relevance 0.82 Pain Relevance 0.04
Coenzyme Q10 effects in neurodegenerative disease

Coenzyme Q10 (CoQ10) is an essential cofactor in the mitochondrial respiratory chain, and as a dietary supplement it has recently gained attention for its potential role in the treatment of neurodegenerative disease.

Regulation (effects) of Coenzyme Q10 in respiratory associated with neurodegenerative disease
3) Confidence 0.23 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Title Doc Link PMC2785862 Disease Relevance 1.11 Pain Relevance 0
Coenzyme Q10 effects in neurodegenerative disease

Coenzyme Q10 (CoQ10) is an essential cofactor in the mitochondrial respiratory chain, and as a dietary supplement it has recently gained attention for its potential role in the treatment of neurodegenerative disease.

Regulation (effects) of Coenzyme Q10 in respiratory associated with neurodegenerative disease
4) Confidence 0.23 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Title Doc Link PMC2785862 Disease Relevance 1.09 Pain Relevance 0
Coenzyme Q10 effects in neurodegenerative disease

Coenzyme Q10 (CoQ10) is an essential cofactor in the mitochondrial respiratory chain, and as a dietary supplement it has recently gained attention for its potential role in the treatment of neurodegenerative disease.

Regulation (effects) of CoQ10 in respiratory associated with neurodegenerative disease
5) Confidence 0.23 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Title Doc Link PMC2785862 Disease Relevance 1.11 Pain Relevance 0
To confirm the cytotoxic effect of GM1 and A?
Regulation (effect) of GM1
6) Confidence 0.22 Published 2010 Journal ASN NEURO Section Body Doc Link PMC2838405 Disease Relevance 0.09 Pain Relevance 0
These results suggest that the decrease in serum CoQ10 levels after TPN is dependent on dietary (exogenous) CoQ10 and that the residual serum CoQ10 levels following TPN are dependent on biosynthesized (endogenous) CoQ10.
Regulation (dependent) of CoQ10
7) Confidence 0.19 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2275764 Disease Relevance 0.12 Pain Relevance 0
There has been some controversy as to whether anti-GM1 antibodies truly affect sodium channels at the nodes of Ranvier [23, 24].
Regulation (affect) of GM1 in nodes associated with sodium channel
8) Confidence 0.03 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3010740 Disease Relevance 1.03 Pain Relevance 0.19

General Comments

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