INT228549

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Context Info
Confidence 0.36
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 14
Disease Relevance 7.36
Pain Relevance 0.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (Coq10a) cellular_component (Coq10a) biological_process (Coq10a)
Anatomy Link Frequency
heart 6
substantia nigra 2
liver 2
striatum 2
surface structures 2
Coq10a (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 10 97.68 Very High Very High Very High
cytokine 2 96.64 Very High Very High Very High
Substantia nigra 18 95.20 Very High Very High Very High
fibrosis 20 78.40 Quite High
Central nervous system 8 68.12 Quite High
cerebral cortex 14 59.24 Quite High
Pain 9 44.64 Quite Low
Hippocampus 6 9.44 Low Low
Bioavailability 16 8.80 Low Low
Dopamine 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 222 99.96 Very High Very High Very High
Stress 168 98.16 Very High Very High Very High
INFLAMMATION 14 97.68 Very High Very High Very High
Neurodegenerative Disease 112 97.04 Very High Very High Very High
Alzheimer's Dementia 80 95.32 Very High Very High Very High
Mitochondrial Encephalomyopathies 4 94.60 High High
Death 32 93.92 High High
Cancer 6 92.56 High High
Hyperlipidemia 14 92.20 High High
Necrosis 13 92.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Levels of CoQ10 in the brain and other tissues in humans and animals have been shown to decline with age, further suggesting a potential therapeutic role in age-related neurodegenerative disorders.1–3 Moreover, the substantia nigra, in which cell death results in the disabling motor symptoms of PD, has the lowest CoQ10 content within the brain.4 In light of these findings, in recent years a series of clinical trials have been undertaken in order to test CoQ10 effects in neurodegenerative disease.
Negative_regulation (decline) of Gene_expression (Levels) of CoQ10 in substantia nigra associated with substantia nigra, disease, neurodegenerative disease and death
1) Confidence 0.36 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2785862 Disease Relevance 1.38 Pain Relevance 0.05
Coincident with aberrant mitochondrial function in PD, CoQ10 levels are significantly decreased in mitochondria from SN neurons and platelets in PD patients, and levels of CoQ10 have been shown to correlate with activity of complexes I and II/III.37 Decreased levels of CoQ10 in brain cortex relative to age-matched controls have also been demonstrated, though no reduction was found in the SN, cerebellum, or striatum.51 In serum, there is a reduction in the ratio of reduced to oxidized CoQ10 in PD37,52,53 and ALS.38,40 However, serum total levels are no different from controls in PD,54 HD,55 and ALS.40,56

Evidence of neuroprotective effects of coenzyme Q10 in vitro

Negative_regulation (decreased) of Gene_expression (levels) of CoQ10 in striatum associated with disease and motor neuron diseases
2) Confidence 0.36 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2785862 Disease Relevance 1.09 Pain Relevance 0.03
Nine genes are presumed to be involved in CoQ10 biosynthesis, and as of now, mutations in three genes have been shown to result in primary CoQ10 deficiency: PDSS1, PDSS2, and COQ2.21 Duncan and colleagues found an autosomal recessive form of neonatal-onset primary coenzyme Q10 deficiency resulting from a nonsense mutation in COQ9.24
Negative_regulation (involved) of Gene_expression (biosynthesis) of CoQ10
3) Confidence 0.36 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2785862 Disease Relevance 0.96 Pain Relevance 0.06
Nine genes are presumed to be involved in CoQ10 biosynthesis, and as of now, mutations in three genes have been shown to result in primary CoQ10 deficiency: PDSS1, PDSS2, and COQ2.21 Duncan and colleagues found an autosomal recessive form of neonatal-onset primary coenzyme Q10 deficiency resulting from a nonsense mutation in COQ9.24
Negative_regulation (result) of Gene_expression (deficiency) of CoQ10
4) Confidence 0.36 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2785862 Disease Relevance 0.97 Pain Relevance 0.06
No change of cell number was detected in NECs cultured in the presence of either GM1 or A?
Negative_regulation (cultured) of Gene_expression (presence) of GM1
5) Confidence 0.35 Published 2010 Journal ASN NEURO Section Abstract Doc Link PMC2838405 Disease Relevance 0.52 Pain Relevance 0
Certain gangliosides, including GM1, have also been reported to inhibit A?
Negative_regulation (inhibit) of Gene_expression (gangliosides) of GM1
6) Confidence 0.35 Published 2010 Journal ASN NEURO Section Body Doc Link PMC2838405 Disease Relevance 0.42 Pain Relevance 0.10
When simvastatin was administered orally to mice, the levels of oxidized and reduced CoQ9 and CoQ10 in serum, liver, and heart, decreased significantly when compared to those of control.
Negative_regulation (decreased) of Gene_expression (levels) of CoQ10 in heart
7) Confidence 0.35 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Abstract Doc Link PMC2275764 Disease Relevance 0.24 Pain Relevance 0
As shown in Table 1, oral administration of simvastatin significantly decreased not only serum cholesterol levels, but also serum and tissue CoQ9 and CoQ10 levels.
Negative_regulation (decreased) of Gene_expression (levels) of CoQ10
8) Confidence 0.34 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2275764 Disease Relevance 0.09 Pain Relevance 0
Like the levels of CoQ9 and CoQ10 in serum, the levels of CoQ9 and CoQ10 in the liver and heart were significantly lowered by simvastatin administration.
Negative_regulation (lowered) of Gene_expression (levels) of CoQ10 in heart
9) Confidence 0.34 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2275764 Disease Relevance 0.31 Pain Relevance 0
We reported previously [49] that serum CoQ10 levels in patients on total parenteral nutrition (TPN) decreased significantly after TPN and never reached zero following TPN.
Negative_regulation (decreased) of Gene_expression (levels) of CoQ10
10) Confidence 0.30 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2275764 Disease Relevance 0.20 Pain Relevance 0
Necessity of CoQ10 during oral administration of HMG-CoA reductase inhibitor
Negative_regulation (administration) of Gene_expression (Necessity) of CoQ10
11) Confidence 0.30 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2275764 Disease Relevance 0.16 Pain Relevance 0
When simvastatin was administered orally to mice, the levels of oxidized and reduced CoQ9 and CoQ10 in serum, liver, and heart, decreased significantly when compared to those of control.
Negative_regulation (decreased) of in liver Gene_expression (levels) of CoQ10 in heart
12) Confidence 0.12 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Abstract Doc Link PMC2275764 Disease Relevance 0.24 Pain Relevance 0
Like the levels of CoQ9 and CoQ10 in serum, the levels of CoQ9 and CoQ10 in the liver and heart were significantly lowered by simvastatin administration.
Negative_regulation (lowered) of in liver Gene_expression (levels) of CoQ10 in heart
13) Confidence 0.12 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2275764 Disease Relevance 0.31 Pain Relevance 0
F508 defect is correlated with decreased expression of GM1 and with decreased sialylation of all cell surface structures, and this change occurs during post-translational modification of glycoproteins and glycolipids.
Negative_regulation (decreased) of Gene_expression (expression) of GM1 in surface structures
14) Confidence 0.04 Published 2009 Journal The Open Respiratory Medicine Journal Section Abstract Doc Link PMC2703207 Disease Relevance 0.46 Pain Relevance 0.17

General Comments

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