INT228570

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Context Info
Confidence 0.61
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 24
Total Number 36
Disease Relevance 7.90
Pain Relevance 0.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Prkaa2) nucleus (Prkaa2) protein binding, bridging (Prkaa2)
protein complex (Prkaa2) response to stress (Prkaa2) cytoplasm (Prkaa2)
Anatomy Link Frequency
hypothalamus 10
Prkaa2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 13 90.72 High High
agonist 22 87.96 High High
Intracerebroventricular 105 86.68 High High
cINOD 6 23.76 Low Low
cytokine 35 6.64 Low Low
anesthesia 43 5.00 Very Low Very Low Very Low
imagery 26 5.00 Very Low Very Low Very Low
qutenza 13 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
Cholecystokinin 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 828 99.48 Very High Very High Very High
Appetite Loss 294 91.60 High High
Stress 293 91.56 High High
Parkinson's Disease 26 90.68 High High
Cancer 13 83.52 Quite High
Hepatocellular Cancer 13 73.40 Quite High
Aging 21 71.12 Quite High
Targeted Disruption 13 66.16 Quite High
Diabetes Mellitus 16 64.88 Quite High
Metabolic Syndrome 16 64.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, recent reports showed that adiponectin enhanced AMP-activated protein kinase (AMPK) phosphorylation, which resulted in increased fatty acid oxidation [38].
Phosphorylation (phosphorylation) of AMPK
1) Confidence 0.61 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2275770 Disease Relevance 0.60 Pain Relevance 0.04
As well as in response to leptin, in the present study, we demonstrated that IL-6 alone reduced AMPK phosphorylation in the hypothalamus of rats.
Phosphorylation (phosphorylation) of AMPK in hypothalamus
2) Confidence 0.54 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0.16 Pain Relevance 0
Both AMPK and ACC phosphorylation levels, reduced by exercise, were reversed by anti–IL-6 antibody (Figure 6c and d).
Phosphorylation (phosphorylation) of AMPK
3) Confidence 0.54 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0.32 Pain Relevance 0
Leptin reduced AMPK and ACC phosphorylation levels in the hypothalami of control and exercised rats.
Phosphorylation (phosphorylation) of AMPK
4) Confidence 0.54 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0 Pain Relevance 0.03
As previously shown [43], exercise, per se, does not alter AMPK activity in the hypothalamus; however, we observed that the normal inhibition of AMPK phosphorylation and activity in the hypothalamus, induced by leptin administration, was improved in both lean and diet-induced obesity rats after acute protocol of exercise.
Phosphorylation (phosphorylation) of AMPK in hypothalamus associated with obesity
5) Confidence 0.54 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0.30 Pain Relevance 0
To determine the effects of exercise on AMPK-mTOR signaling pathway, leptin was i.c.v. administered and AMPK, ACC, p70S6K and 4EBP1 phosphorylation levels were assessed in the hypothalamus of all rats.
Phosphorylation (phosphorylation) of AMPK in hypothalamus
6) Confidence 0.53 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0 Pain Relevance 0.03
Comparing AICAR treated groups (control vs. exercise), exercised animals showed reductions in AMPK threonine and ACC serine phosphorylation of 52% and 31%, respectively.
Phosphorylation (phosphorylation) of AMPK
7) Confidence 0.47 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0 Pain Relevance 0.03
Comparing leptin-treated groups (control vs. exercise), in exercised animals, leptin reduced both AMPK threonine phosphorylation and ACC serine phosphorylation of 57% and 45%, respectively (Figures 5b and c).
Phosphorylation (phosphorylation) of AMPK
8) Confidence 0.47 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0.06 Pain Relevance 0.03
6 M) to exercised rats pretreated with vehicle reduced AMPK and ACC phosphorylation in the hypothalamus by 63% and 60% respectively, compared with the control group.
Phosphorylation (phosphorylation) of AMPK in hypothalamus
9) Confidence 0.47 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0.32 Pain Relevance 0
Consistent with food intake, AICAR increased AMPK threonine and ACC serine phosphorylation levels in the hypothalami of control rats, whilst in exercised animals, AICAR did not change AMPK/ACC phosphorylation status (Figures 3b and c).
Phosphorylation (phosphorylation) of AMPK
10) Confidence 0.47 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0 Pain Relevance 0.03
Comparing fasting treated groups (control vs. exercise), exercised animals showed reductions in AMPK threonine and ACC serine phosphorylation of 65% and 41%, respectively (Figures 3l and m).
Phosphorylation (phosphorylation) of AMPK
11) Confidence 0.47 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0.05 Pain Relevance 0.04
6 M) to rats pretreated with AICAR increased both AMPK and ACC phosphorylation levels in the hypothalamus (Figures 8b and c).
Phosphorylation (phosphorylation) of AMPK in hypothalamus
12) Confidence 0.47 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0.06 Pain Relevance 0
Once activated, AMPK phosphorylates acetyl-CoA carboxylase (ACC) and switches on energy-producing pathways at the expense of energy-depleting processes [10]–[12].
Phosphorylation (phosphorylates) of AMPK
13) Confidence 0.41 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0.28 Pain Relevance 0
To determine the effects of exercise on the AMPK-mTOR signaling pathway in the hypothalamus of DIO rats, leptin was i.c.v. administered and AMPK, ACC, p70S6K and 4EBP1 phosphorylation levels were assessed in the hypothalamus.
Phosphorylation (phosphorylation) of AMPK in hypothalamus associated with obesity
14) Confidence 0.41 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 1.33 Pain Relevance 0
The suppressive effects of i.c.v. infusion of leptin on AMPK and ACC phosphorylation were impaired in the hypothalamus of DIO rats by about 58 and 54%, respectively, when compared to the control group (Figure 7c and d).
Phosphorylation (phosphorylation) of AMPK in hypothalamus associated with obesity
15) Confidence 0.41 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 1.30 Pain Relevance 0
Alternatively we attempted to examine levels of phosphorylated AMP-activated protein kinase (AMPK) as this reflects the ADP/ATP ratio in cells [26].
Phosphorylation (phosphorylated) of AMP-activated protein kinase
16) Confidence 0.41 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2311291 Disease Relevance 0 Pain Relevance 0
Consistent with food intake, AICAR increased AMPK threonine and ACC serine phosphorylation levels in the hypothalami of control rats, whilst in exercised animals, AICAR did not change AMPK/ACC phosphorylation status (Figures 3b and c).
Phosphorylation (phosphorylation) of AMPK
17) Confidence 0.36 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0 Pain Relevance 0.04
The administration of AICAR increased AMPK threonine and ACC serine phosphorylation, although at this dose, AICAR was not sufficient to induce significant an increase in food intake in exercised animals (data not shown).
Phosphorylation (phosphorylation) of AMPK
18) Confidence 0.36 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0.24 Pain Relevance 0
-LA reduced AMPK and ACC phosphorylation levels, in the hypothalami of control and exercised rats.
Phosphorylation (phosphorylation) of AMPK
19) Confidence 0.36 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0.07 Pain Relevance 0.07
Furthermore, the reduction of AMPK and ACC phosphorylation and increase in phosphorylation of proteins involved in mTOR signal transduction, observed in the hypothalamus after leptin infusion, were more pronounced in both lean and diet-induced obesity rats after acute exercise.
Phosphorylation (phosphorylation) of AMPK in hypothalamus associated with obesity
20) Confidence 0.36 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2585815 Disease Relevance 0.25 Pain Relevance 0.04

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