INT228582

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Context Info
Confidence 0.13
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.88
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gck) nucleoplasm (Gck) mitochondrion (Gck)
nucleus (Gck) carbohydrate metabolic process (Gck) kinase activity (Gck)
Anatomy Link Frequency
liver 1
Gck (Rattus norvegicus)
Pain Link Frequency Relevance Heat
tolerance 6 5.00 Very Low Very Low Very Low
agonist 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Appetite Loss 129 91.52 High High
Metabolic Syndrome 20 75.88 Quite High
Diabetes Mellitus 7 74.64 Quite High
Obesity 10 72.56 Quite High
Disorder Of Lipid Metabolism 2 50.32 Quite High
Body Weight 17 31.68 Quite Low
Metabolic Disorder 7 18.24 Low Low
Impaired Glucose Tolerance 8 5.00 Very Low Very Low Very Low
Hyperglycemia 5 5.00 Very Low Very Low Very Low
Insulin Resistance 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the liver low protein in the diet induces a decrease in the production of glucokinase and increase in phosphoenolpyruvate carboxykinase, two enzymes involved in the glycolytic and gluconeogenic functions, respectively, resulting in a higher level of continuous endogenous glucose production by the liver 10.
Positive_regulation (increase) of glucokinase in liver
1) Confidence 0.13 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2586678 Disease Relevance 0.83 Pain Relevance 0
There were no differences in the mRNA levels of the hepatic glycolytic genes (such as glucokinase and pyruvate kinase), and hepatic gluconeogenic genes (such as glucose 6-phosphatase (G6Pase) and phosphoenolpyrvate carboxykinase (PEPCK)) between the Inslow and SF groups (data not shown).
Positive_regulation (levels) of glucokinase
2) Confidence 0.07 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2275770 Disease Relevance 0.05 Pain Relevance 0

General Comments

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