INT228606

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Context Info
Confidence 0.02
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.96
Pain Relevance 0.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (ERG) signal transduction (ERG) nucleus (ERG)
DNA binding (ERG) cytoplasm (ERG) signal transducer activity (ERG)
Anatomy Link Frequency
lens 4
eye 2
photoreceptor cell 2
ERG (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 90 90.92 High High
tolerance 12 5.00 Very Low Very Low Very Low
anesthesia 10 5.00 Very Low Very Low Very Low
ketamine 4 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
Immobilon 3 5.00 Very Low Very Low Very Low
dexamethasone 1 5.00 Very Low Very Low Very Low
cva 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 51 99.32 Very High Very High Very High
Gliosis 12 97.80 Very High Very High Very High
INFLAMMATION 90 91.64 High High
Uveitis 12 85.88 High High
Macular Edema 6 85.44 High High
Necrosis 6 68.40 Quite High
Corneal Edema 3 68.40 Quite High
Cancer 9 68.04 Quite High
Shock 3 65.32 Quite High
Ganglion Cysts 2 22.04 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This also correlated with neuroretinal trauma evidenced by a sustained loss in ERG function, increased GFAP levels indicative of active Muller as well as astrocyte cell gliosis, and significant photoreceptor cell degeneration.
Positive_regulation (increased) of Gene_expression (levels) of ERG in photoreceptor cell associated with injury and gliosis
1) Confidence 0.02 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2276183 Disease Relevance 1.10 Pain Relevance 0.15
This indicates why ERG reductions as a consequence of intracameral inoculation proved significantly less pronounced than those for mice receiving a lens puncture wound
Positive_regulation (why) of Gene_expression (reductions) of ERG in lens associated with injury
2) Confidence 0.02 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2276183 Disease Relevance 0.43 Pain Relevance 0.11
This indicates why ERG reductions as a consequence of intracameral inoculation proved significantly less pronounced than those for mice receiving a lens puncture wound
Positive_regulation (proved) of Gene_expression (reductions) of ERG in lens associated with injury
3) Confidence 0.02 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2276183 Disease Relevance 0.44 Pain Relevance 0.11
The rd12 eye, which received a subretinal injection four weeks after an intravitreal injection in the contralateral eye of the same mouse (Figure 3C), showed robust, dark-adapted ERG restoration five months after the subretinal injection.
Positive_regulation (adapted) of Gene_expression (restoration) of ERG in eye
4) Confidence 0.02 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2633462 Disease Relevance 0 Pain Relevance 0

General Comments

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