INT228608

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Context Info
Confidence 0.68
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 2.85
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Epo) extracellular region (Epo)
Anatomy Link Frequency
fat 4
Epo (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 6 68.20 Quite High
Pain 6 63.44 Quite High
tolerance 4 47.04 Quite Low
Inflammatory response 22 5.00 Very Low Very Low Very Low
fibrosis 8 5.00 Very Low Very Low Very Low
Inflammation 8 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
ketamine 4 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
cva 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Anaemia 50 98.00 Very High Very High Very High
Thalassemia 4 93.44 High High
Chronic Renal Failure 8 92.28 High High
Obesity 54 92.08 High High
Immunotherapy Of Cancer 4 91.28 High High
Injury 4 71.36 Quite High
Diabetes Mellitus 2 70.56 Quite High
Renal Failure 4 64.40 Quite High
Apoptosis 68 60.00 Quite High
Erythrocytosis 12 44.88 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, erythropoietin (Epo) gene transfer appears to be a promising alternative for severe anaemia treatment since it requires less frequent treatment repeat and may allow sustained Epo secretion and constant patient coverage.
Positive_regulation (transfer) of Gene_expression (transfer) of Epo associated with anaemia
1) Confidence 0.68 Published 2008 Journal Genet Vaccines Ther Section Body Doc Link PMC2276190 Disease Relevance 0.60 Pain Relevance 0
Epo gene transfer has already been tested on normal animals and on anaemia animal models such as ?
Positive_regulation (transfer) of Gene_expression (transfer) of Epo associated with anaemia
2) Confidence 0.68 Published 2008 Journal Genet Vaccines Ther Section Body Doc Link PMC2276190 Disease Relevance 0.63 Pain Relevance 0
Indeed, the increased VEGFR-2 expression in the EPO-treated fat grafts that was observed in our study implies that EPO-induced endogenous VEGF secretion in the fat grafts might be more effective than exogenous VEGF administration.
Positive_regulation (increased) of Gene_expression (expression) of EPO in fat
3) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2981551 Disease Relevance 0.41 Pain Relevance 0.03
Indeed, the increased VEGFR-2 expression in the EPO-treated fat grafts that was observed in our study implies that EPO-induced endogenous VEGF secretion in the fat grafts might be more effective than exogenous VEGF administration.
Positive_regulation (induced) of Gene_expression (expression) of EPO in fat
4) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2981551 Disease Relevance 0.42 Pain Relevance 0.03
Therefore, erythropoietin (Epo) gene transfer appears to be a promising alternative for severe anaemia treatment since it requires less frequent treatment repeat and may allow sustained Epo secretion and constant patient coverage.
Positive_regulation (transfer) of Gene_expression (transfer) of erythropoietin associated with anaemia
5) Confidence 0.49 Published 2008 Journal Genet Vaccines Ther Section Body Doc Link PMC2276190 Disease Relevance 0.60 Pain Relevance 0
Furthermore, we may hypothesise that this administration schedule which leads to low Epo endogenous production, may limit humoral response which has been clearly correlated to transgene expression level [26].
Positive_regulation (leads) of Gene_expression (production) of Epo
6) Confidence 0.49 Published 2008 Journal Genet Vaccines Ther Section Body Doc Link PMC2276190 Disease Relevance 0.19 Pain Relevance 0.06

General Comments

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