INT228613

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Context Info
Confidence 0.42
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.08
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (EXT1) transferase activity, transferring glycosyl groups (EXT1) Golgi apparatus (EXT1)
endoplasmic reticulum (EXT1)
EXT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 20 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
Spinal cord 2 5.00 Very Low Very Low Very Low
Arthritis 2 5.00 Very Low Very Low Very Low
medulla 2 5.00 Very Low Very Low Very Low
positron emission tomography 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Chondrosarcoma 28 99.90 Very High Very High Very High
Osteochondroma 94 99.80 Very High Very High Very High
Multiple Hereditary Exostoses 90 71.28 Quite High
Cancer 16 63.68 Quite High
Cleidocranial Dysplasia 6 57.12 Quite High
Malignant Neoplastic Disease 32 14.24 Low Low
Pain 20 5.00 Very Low Very Low Very Low
Congenital Anomalies 10 5.00 Very Low Very Low Very Low
Enchondromatosis 8 5.00 Very Low Very Low Very Low
Bone Cancer 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In osteochondromas and peripheral chondrosarcomas the expression of EXT1 and/or EXT2 is decreased, corresponding to the mutation status [47].
Negative_regulation (decreased) of Gene_expression (expression) of EXT1 associated with chondrosarcoma and osteochondroma
1) Confidence 0.42 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2276198 Disease Relevance 0.78 Pain Relevance 0
In osteochondromas in which EXT expression is decreased due to mutation or deletion, the heparan sulphate proteoglycans seem to accumulate in the cytoplasm of the cell, instead of being transported to be expressed at the cell surface [47].
Negative_regulation (decreased) of Gene_expression (expression) of EXT associated with osteochondroma
2) Confidence 0.37 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2276198 Disease Relevance 0.30 Pain Relevance 0

General Comments

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