INT228618

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Context Info
Confidence 0.77
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 3.70
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (EXT1) transferase activity, transferring glycosyl groups (EXT1) Golgi apparatus (EXT1)
endoplasmic reticulum (EXT1)
Anatomy Link Frequency
liver 1
limb buds 1
EXT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 30 5.00 Very Low Very Low Very Low
imagery 10 5.00 Very Low Very Low Very Low
Spinal cord 3 5.00 Very Low Very Low Very Low
Arthritis 3 5.00 Very Low Very Low Very Low
medulla 3 5.00 Very Low Very Low Very Low
positron emission tomography 3 5.00 Very Low Very Low Very Low
palliative 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Chondrosarcoma 42 99.90 Very High Very High Very High
Osteochondroma 141 99.80 Very High Very High Very High
Cancer 180 99.12 Very High Very High Very High
Recurrence 8 97.72 Very High Very High Very High
Hepatocellular Cancer 80 93.36 High High
Cirrhosis 14 88.00 High High
Liver Disease 26 85.04 High High
Multiple Hereditary Exostoses 135 82.40 Quite High
Cleidocranial Dysplasia 9 68.24 Quite High
Malignant Neoplastic Disease 52 13.20 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In osteochondromas and peripheral chondrosarcomas the expression of EXT1 and/or EXT2 is decreased, corresponding to the mutation status [47].
Gene_expression (expression) of EXT1 associated with chondrosarcoma and osteochondroma
1) Confidence 0.77 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2276198 Disease Relevance 0.77 Pain Relevance 0
A high level of expression of Ext1 and Ext2 mRNA has been found in developing limb buds of mouse embryos [44,45] and expression was demonstrated to be confined to the proliferating and prehypertrophic chondrocytes of the growth plate [46].
Gene_expression (expression) of Ext1 in limb buds
2) Confidence 0.67 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2276198 Disease Relevance 0.77 Pain Relevance 0
In osteochondromas in which EXT expression is decreased due to mutation or deletion, the heparan sulphate proteoglycans seem to accumulate in the cytoplasm of the cell, instead of being transported to be expressed at the cell surface [47].
Gene_expression (expression) of EXT associated with osteochondroma
3) Confidence 0.59 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2276198 Disease Relevance 0.30 Pain Relevance 0
Since TTV can be used to reflect the status of tumor burden, it is not surprising that a larger TTV is expected to be more often associated with a higher AFP level and vascular invasion.
Gene_expression (expected) of TTV associated with cancer
4) Confidence 0.36 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC3022616 Disease Relevance 1.20 Pain Relevance 0
This cutoff is considered appropriate for clinical application because TTV <50 cm3 is within the Milan criteria, suggesting the risk of tumor recurrence is very low after liver transplantation or partial hepatectomy [9,27].
Gene_expression (is) of TTV in liver associated with cancer and recurrence
5) Confidence 0.36 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC3022616 Disease Relevance 0.65 Pain Relevance 0

General Comments

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