INT228620

Context Info Confidence 0.71 First Reported 2008 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 3 Disease Relevance 2.67 Pain Relevance 0

signal transduction (EXT1) transferase activity, transferring glycosyl groups (EXT1) Golgi apparatus (EXT1) endoplasmic reticulum (EXT1)

Anatomy Link Frequency nodule 1 limb buds 1 EXT1 (Homo sapiens)

Pain Link Frequency Relevance Heat Pain 20 5.00 imagery 6 5.00 Spinal cord 2 5.00 Arthritis 2 5.00 medulla 2 5.00 positron emission tomography 2 5.00 palliative 1 5.00

Disease Link Frequency Relevance Heat Immunotherapy Of Cancer 1 99.88 Cancer 94 99.04 Osteochondroma 94 90.36 Multiple Hereditary Exostoses 90 85.20 Chondrosarcoma 28 80.80 Liver Disease 13 75.72 Infection 4 74.96 Hepatitis C Virus Infection 4 74.56 Hepatitis B Virus Infection 3 72.72 Cleidocranial Dysplasia 6 71.04

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Both EXT1 and EXT2 mRNA is ubiquitously expressed [17-19].

Transcription (expressed) of EXT1

1) Confidence 0.71 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2276198 Disease Relevance 0.79 Pain Relevance 0

A high level of expression of Ext1 and Ext2 mRNA has been found in developing limb buds of mouse embryos [44,45] and expression was demonstrated to be confined to the proliferating and prehypertrophic chondrocytes of the growth plate [46].

Transcription (expression) of Ext1 in limb buds

2) Confidence 0.53 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2276198 Disease Relevance 0.77 Pain Relevance 0

Distribution and association of TTV and number and size of tumor nodule

Transcription (Distribution) of TTV in nodule associated with cancer

3) Confidence 0.37 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC3022616 Disease Relevance 1.11 Pain Relevance 0

General Comments

This test has worked.