INT228644

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Context Info
Confidence 0.46
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 4.21
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SERPING1) extracellular region (SERPING1)
Anatomy Link Frequency
plasma 2
SERPING1 (Homo sapiens)
Pain Link Frequency Relevance Heat
bradykinin 64 91.72 High High
Inflammation 9 88.72 High High
Pain 16 76.48 Quite High
Pain score 3 41.08 Quite Low
abdominal pain 4 27.08 Quite Low
antagonist 17 5.00 Very Low Very Low Very Low
vincristine 3 5.00 Very Low Very Low Very Low
Onset of action 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hereditary Angioedema 193 99.84 Very High Very High Very High
Lymphatic System Cancer 8 99.64 Very High Very High Very High
Pressure And Volume Under Development 179 98.46 Very High Very High Very High
Disease 35 95.76 Very High Very High Very High
Insulin Resistance 2 92.40 High High
Diabetes Mellitus 56 91.56 High High
INFLAMMATION 9 88.72 High High
Injury 6 88.04 High High
Infection 5 87.72 High High
Lymphoproliferative Disease 3 80.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Autoantibody-mediated AAE seemed to be, at the beginning, a new type of AAE in which autoreactive immunoglobulins, instead of lymphoma tissues, was the cause of C1-INH depletion [20].
Positive_regulation (cause) of Negative_regulation (depletion) of C1-INH associated with pressure and volume under development and lymphatic system cancer
1) Confidence 0.46 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2925362 Disease Relevance 1.77 Pain Relevance 0
Inappropriate activation of these plasma pathways, particularly of the complement and contact systems, as a result of C1-inhibitor deficiency, is a central component in the pathophysiology of HAE [1,2,8,18,19].
Positive_regulation (result) of Negative_regulation (deficiency) of C1-inhibitor in plasma associated with hereditary angioedema
2) Confidence 0.42 Published 2008 Journal Clin Mol Allergy Section Body Doc Link PMC2374835 Disease Relevance 0.80 Pain Relevance 0.04
These low levels suggest enhanced depletion of C1-inhibitor – the rate of consumption exceeding the rate of ongoing synthesis – in patients with the genetic defect, even during asymptomatic periods [9].
Positive_regulation (enhanced) of Negative_regulation (depletion) of C1-inhibitor
3) Confidence 0.42 Published 2008 Journal Clin Mol Allergy Section Body Doc Link PMC2374835 Disease Relevance 0.57 Pain Relevance 0
Although C1-inhibitor deficiency has been known to be the underlying cause of HAE for more than 40 years, the actual mediator(s) of the vascular permeability characteristic of the disease remains the subject of continued investigation.
Positive_regulation (cause) of Negative_regulation (deficiency) of C1-inhibitor associated with hereditary angioedema and disease
4) Confidence 0.40 Published 2008 Journal Clin Mol Allergy Section Body Doc Link PMC2374835 Disease Relevance 0.49 Pain Relevance 0.16
Diet, exercise and oral agents are effective for reducing A1C; however, they do not sufficiently compensate for progressively worsening ?
Positive_regulation (effective) of Negative_regulation (reducing) of A1C
5) Confidence 0.01 Published 2008 Journal Osteopath Med Prim Care Section Body Doc Link PMC2276216 Disease Relevance 0.50 Pain Relevance 0

General Comments

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