INT228659

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Context Info
Confidence 0.80
First Reported 2008
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 10
Total Number 88
Disease Relevance 27.53
Pain Relevance 6.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Eif4ebp1) protein complex (Eif4ebp1) cytoplasm (Eif4ebp1)
Anatomy Link Frequency
brain 6
PP2A 5
skin 3
cerebral cortex 2
Eif4ebp1 (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 2844 99.72 Very High Very High Very High
cerebral cortex 792 98.92 Very High Very High Very High
addiction 79 88.80 High High
Inflammatory response 4 87.24 High High
Sciatic nerve 20 85.04 High High
alcohol 79 80.80 Quite High
calcitonin gene related peptide 4 79.60 Quite High
Calcitonin gene-related peptide 36 76.24 Quite High
Pain 32 67.48 Quite High
nociceptor 164 64.44 Quite High
Disease Link Frequency Relevance Heat
Stress 2250 99.82 Very High Very High Very High
Cv Unclassified Under Development 2765 99.72 Very High Very High Very High
Hypoxia 480 98.56 Very High Very High Very High
Cancer 553 98.00 Very High Very High Very High
Apoptosis 1 92.60 High High
Disease 200 91.68 High High
INFLAMMATION 17 86.88 High High
Brain Disease 79 83.44 Quite High
Repression 79 81.60 Quite High
Toxicity 96 80.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The mTOR inhibitor rapamycin blocks the phosphorylation of 4E-BP1/2, S6K and S6 in skin
Phosphorylation (phosphorylation) of 4E-BP1 in skin
1) Confidence 0.80 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2276314 Disease Relevance 0.06 Pain Relevance 0.33
Activity of mTOR in the skin was assessed by quantifying phosphorylation of direct downstream targets 4E-BP1/2 and S6K.
Phosphorylation (phosphorylation) of 4E-BP1 in skin
2) Confidence 0.80 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2276314 Disease Relevance 0.07 Pain Relevance 0.32
This results in decreased mTOR kinase activity, inhibited phosphorylation of downstream targets such as p70 ribosomal protein S6 kinase (S6RP) and 4E-binding protein (4E-BP1), and potentially suppression of ribosome biogenesis and protein translation [3], [17].
Phosphorylation (phosphorylation) of 4E-BP1
3) Confidence 0.79 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2882366 Disease Relevance 0.64 Pain Relevance 0
No.: 2972), anti-phospho-4E-BP1/2 (Thr37/46; 1?
Phosphorylation (phospho) of 4E-BP1
4) Confidence 0.79 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2276314 Disease Relevance 0.13 Pain Relevance 0.27
Specifically, western blot analysis showed a significant decrease in 4E-BP1/2 and S6K phosphorylation in the skin 30 min after injection of rapamycin compared to vehicle (Fig. 3A, P<0.01 for both proteins).
Phosphorylation (phosphorylation) of 4E-BP1 in skin
5) Confidence 0.61 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2276314 Disease Relevance 0.09 Pain Relevance 0.07
We hypothesize that in brain tissue, the mTORC1 signal could be primarily operating through TOS motif, inducing 4E-BP1 phosphorylation at Thr69.
Phosphorylation (phosphorylation) of 4E-BP1 in brain
6) Confidence 0.36 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2966049 Disease Relevance 0.42 Pain Relevance 0
The mTOR phosphorylation at Ser2448 (and Ser2481 autophosphorylation) and 4E-BP1 phosphorylation were restored during reperfusion and returned to control values.
Phosphorylation (phosphorylation) of 4E-BP1
7) Confidence 0.36 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2966049 Disease Relevance 0.35 Pain Relevance 0.05
Finally, if phosphorylation of 4E-BP1 at Th36/Thr45 alone without phospho-Thr69 is present, a new spot might be detected in two-dimensional experiments.
Phosphorylation (phosphorylation) of 4E-BP1
8) Confidence 0.36 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2966049 Disease Relevance 0.16 Pain Relevance 0
This study also addressed the role of 4E-BP1 phosphorylation in the activity of eIF4E.
Phosphorylation (phosphorylation) of 4E-BP1
9) Confidence 0.36 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2966049 Disease Relevance 0.55 Pain Relevance 0.08
form, with 4E-BP1 remaining phosphorylated at Thr69 and dephosphorylated at Thr36/Thr45 in the ?
Phosphorylation (phosphorylated) of 4E-BP1
10) Confidence 0.36 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2966049 Disease Relevance 0.08 Pain Relevance 0.04
Therefore, there are two mTOR-dependent inputs that regulate the phosphorylation sites in 4E-BP1.
Phosphorylation (phosphorylation) of 4E-BP1
11) Confidence 0.36 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2966049 Disease Relevance 0.19 Pain Relevance 0
The hierarchical phosphorylation of 4E-BP1 at these sites is stimulated by agents such as insulin, growth factors and serum, and in many cell types, this effect requires the presence of amino acids in the culture medium.
Phosphorylation (phosphorylation) of 4E-BP1
12) Confidence 0.36 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2966049 Disease Relevance 0 Pain Relevance 0
The individual contribution of the 4E-BP1 phosphorylation sites to the control of eIF4E binding remains controversial. 4E-BP1 phosphorylated on Th36/Thr45 retains the ability to interact with eIF4E (10).
Phosphorylation (phosphorylation) of 4E-BP1
13) Confidence 0.36 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2966049 Disease Relevance 0.53 Pain Relevance 0.07
The new sequence in the phosphorylation of 4E-BP1 suggests that it may be brain tissue-specific.
Phosphorylation (phosphorylation) of 4E-BP1 in brain
14) Confidence 0.36 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2966049 Disease Relevance 0.15 Pain Relevance 0.04
form, with 4E-BP1 remaining phosphorylated at Thr69 and dephosphorylated at Thr36/Thr45 in the ?
Phosphorylation (dephosphorylated) of 4E-BP1
15) Confidence 0.36 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2966049 Disease Relevance 0.08 Pain Relevance 0.04
Also, it has been reported that ROS inhibit protein phosphatase 2A (PP2A) (41, 42), phosphatase activity that has been implicated in regulation of 4E-BP1 phosphorylation (7, 30, 43). 4E-BP1 phosphorylation at Ser64, but not Thr69, is induced by ROS (44).
Phosphorylation (phosphorylation) of 4E-BP1 in PP2A
16) Confidence 0.36 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2966049 Disease Relevance 0.20 Pain Relevance 0.04
Hypoxic stress causes energy deprivation, and inhibition of mTORC1 by means of 4E-BP1 hypophosphorylation inhibits energy-consuming processes such as protein synthesis.
Phosphorylation (hypophosphorylation) of 4E-BP1 associated with stress and hypoxia
17) Confidence 0.36 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2966049 Disease Relevance 0.91 Pain Relevance 0.15
Energy depletion severely decreases mTORC1 activity (7, 11), and because the translation is a major consumer of cellular energy, mTORC1 inactivation through 4E-BP1 hypophosphorylation induces translation inhibition.
Phosphorylation (hypophosphorylation) of 4E-BP1
18) Confidence 0.36 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2966049 Disease Relevance 0.48 Pain Relevance 0.04
Insulin treatment of cells after deprivation is known to modify phosphorylation of 4E-BP1 at Thr36/Thr45 as the first event in cell lines (9, 23, 29, 37).
Phosphorylation (phosphorylation) of 4E-BP1
19) Confidence 0.36 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2966049 Disease Relevance 0.09 Pain Relevance 0.05
Activation of mTORC1 results in phosphorylation of 4E-BP1 at Thr36, Thr45, Ser64, and Thr69 sites and the release of 4E-BP1 from eIF4E (6, 7).
Phosphorylation (phosphorylation) of 4E-BP1
20) Confidence 0.36 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2966049 Disease Relevance 0 Pain Relevance 0

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