INT228660

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Context Info
Confidence 0.41
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 1.19
Pain Relevance 0.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Eif4ebp1) protein complex (Eif4ebp1) cytoplasm (Eif4ebp1)
Anatomy Link Frequency
skin 1
Eif4ebp1 (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 144 97.84 Very High Very High Very High
Inflammatory response 1 87.72 High High
cerebral cortex 40 68.80 Quite High
Sciatic nerve 5 53.12 Quite High
Calcitonin gene-related peptide 9 42.32 Quite Low
addiction 4 32.24 Quite Low
nociceptor 41 26.12 Quite Low
qutenza 39 5.00 Very Low Very Low Very Low
Hyperalgesia 28 5.00 Very Low Very Low Very Low
withdrawal 14 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 113 99.22 Very High Very High Very High
Cv Unclassified Under Development 140 97.84 Very High Very High Very High
Hypoxia 25 89.60 High High
INFLAMMATION 4 87.36 High High
Nociception 6 22.56 Low Low
Hyperalgesia 31 5.00 Very Low Very Low Very Low
Cancer 24 5.00 Very Low Very Low Very Low
Pain 13 5.00 Very Low Very Low Very Low
Injury 10 5.00 Very Low Very Low Very Low
Nervous System Injury 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Specifically, western blot analysis showed a significant decrease in 4E-BP1/2 and S6K phosphorylation in the skin 30 min after injection of rapamycin compared to vehicle (Fig. 3A, P<0.01 for both proteins).
Negative_regulation (decrease) of 4E-BP1 in skin
1) Confidence 0.41 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2276314 Disease Relevance 0.09 Pain Relevance 0.07
Energy depletion severely decreases mTORC1 activity (7, 11), and because the translation is a major consumer of cellular energy, mTORC1 inactivation through 4E-BP1 hypophosphorylation induces translation inhibition.
Negative_regulation (inactivation) of 4E-BP1
2) Confidence 0.19 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2966049 Disease Relevance 0.48 Pain Relevance 0.03
R30 induced a significant decrease in 4E-BP1 bound to eIF4E when compared with the SHC control or I15 condition, and accordingly, induced a significant increase in eIF4G/eIF4E association (Fig. 4; supplemental Fig.
Negative_regulation (decrease) of 4E-BP1 associated with ischemia
3) Confidence 0.19 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2966049 Disease Relevance 0.18 Pain Relevance 0.13
Our results showed that inhibition of mTORC1 activity was induced by ischemic stress, which was confirmed by a significant decrease in 4E-BP1 and mTOR-Ser2448 phosphorylation.
Negative_regulation (decrease) of 4E-BP1 associated with stress
4) Confidence 0.19 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2966049 Disease Relevance 0.35 Pain Relevance 0.04
Oxygen-glucose deprivation or insulin deprivation induced dephosphorylation of 4E-BP1 at Thr36/Thr45 and Ser64 residues in the ?
Negative_regulation (deprivation) of 4E-BP1
5) Confidence 0.19 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2966049 Disease Relevance 0.09 Pain Relevance 0.04

General Comments

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