INT228661

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Context Info
Confidence 0.41
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 2.25
Pain Relevance 1.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Eif4ebp1) protein complex (Eif4ebp1) cytoplasm (Eif4ebp1)
Anatomy Link Frequency
skin 6
Eif4ebp1 (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 72 94.88 High High
Sciatic nerve 15 85.48 High High
Inflammatory response 3 74.88 Quite High
Calcitonin gene-related peptide 27 74.68 Quite High
nociceptor 123 58.48 Quite High
addiction 2 57.52 Quite High
unmyelinated 12 29.56 Quite Low
qutenza 117 5.00 Very Low Very Low Very Low
Hyperalgesia 84 5.00 Very Low Very Low Very Low
withdrawal 42 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 76 99.36 Very High Very High Very High
Hypoxia 15 99.22 Very High Very High Very High
Cv Unclassified Under Development 70 94.88 High High
Apoptosis 1 93.00 High High
Cancer 88 91.04 High High
Sarcoma 8 77.44 Quite High
INFLAMMATION 13 74.88 Quite High
Osteogenic Sarcomas 25 50.00 Quite Low
Residual Neoplasm 3 27.20 Quite Low
Hyperalgesia 93 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The mTOR inhibitor rapamycin blocks the phosphorylation of 4E-BP1/2, S6K and S6 in skin
Negative_regulation (blocks) of Phosphorylation (phosphorylation) of 4E-BP1 in skin
1) Confidence 0.41 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2276314 Disease Relevance 0.06 Pain Relevance 0.33
Activity of mTOR in the skin was assessed by quantifying phosphorylation of direct downstream targets 4E-BP1/2 and S6K.
Negative_regulation (quantifying) of Phosphorylation (phosphorylation) of 4E-BP1 in skin
2) Confidence 0.41 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2276314 Disease Relevance 0.07 Pain Relevance 0.32
The mTOR inhibitor rapamycin blocks the phosphorylation of 4E-BP1/2, S6K and S6 in skin
Negative_regulation (skin) of Phosphorylation (phosphorylation) of 4E-BP1 in skin
3) Confidence 0.41 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2276314 Disease Relevance 0.07 Pain Relevance 0.33
This results in decreased mTOR kinase activity, inhibited phosphorylation of downstream targets such as p70 ribosomal protein S6 kinase (S6RP) and 4E-binding protein (4E-BP1), and potentially suppression of ribosome biogenesis and protein translation [3], [17].
Negative_regulation (inhibited) of Phosphorylation (phosphorylation) of 4E-BP1
4) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2882366 Disease Relevance 0.64 Pain Relevance 0
Energy depletion severely decreases mTORC1 activity (7, 11), and because the translation is a major consumer of cellular energy, mTORC1 inactivation through 4E-BP1 hypophosphorylation induces translation inhibition.
Negative_regulation (inactivation) of Phosphorylation (hypophosphorylation) of 4E-BP1
5) Confidence 0.25 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2966049 Disease Relevance 0.48 Pain Relevance 0.04
Hypoxic stress causes energy deprivation, and inhibition of mTORC1 by means of 4E-BP1 hypophosphorylation inhibits energy-consuming processes such as protein synthesis.
Negative_regulation (inhibition) of Phosphorylation (hypophosphorylation) of 4E-BP1 associated with stress and hypoxia
6) Confidence 0.19 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2966049 Disease Relevance 0.91 Pain Relevance 0.15
Vitamin E increases phosphorylation compared with control and impairs the ability of rapamycin to inhibit the phosphorylation of 4E-BP1.
Negative_regulation (inhibit) of Phosphorylation (phosphorylation) of 4E-BP1
7) Confidence 0.01 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2916709 Disease Relevance 0 Pain Relevance 0

General Comments

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