INT228671

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Context Info
Confidence 0.50
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 1.77
Pain Relevance 1.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Mtor) mitochondrion (Mtor) Golgi apparatus (Mtor)
endoplasmic reticulum (Mtor) nucleus (Mtor) kinase activity (Mtor)
Anatomy Link Frequency
hypothalamus 4
skin 4
muscle 2
Mtor (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammatory response 3 94.92 High High
long-term potentiation 9 94.72 High High
Paracetamol 120 89.96 High High
Intracerebroventricular 10 87.20 High High
Sciatic nerve 15 86.48 High High
Calcitonin gene-related peptide 27 75.68 Quite High
nociceptor 123 59.48 Quite High
Hippocampus 25 39.92 Quite Low
unmyelinated 12 30.56 Quite Low
anesthesia 6 16.76 Low Low
Disease Link Frequency Relevance Heat
Tuberous Sclerosis 2 98.88 Very High Very High Very High
Obesity 83 95.00 High High
INFLAMMATION 15 94.56 High High
Appetite Loss 28 92.12 High High
Aging 79 86.68 High High
Neointima 11 86.40 High High
Starvation 2 83.84 Quite High
Frailty 10 71.36 Quite High
Vasculitis 2 67.92 Quite High
Apoptosis 20 66.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using western blotting and immunohistochemistry, we found that intraplantar injections of rapamycin reduced phosphorylation of downstream targets of mTOR, therefore suggesting that mTOR activity was inhibited by rapamycin.
Negative_regulation (reduced) of Phosphorylation (phosphorylation) of mTOR
1) Confidence 0.50 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2276314 Disease Relevance 0.09 Pain Relevance 0.08
Compared to cells treated with insulin alone, cells treated with rosiglitazone before insulin stimulus demonstrated significant inhibition of phosphorylated mTOR.


Negative_regulation (inhibition) of Phosphorylation (phosphorylated) of mTOR
2) Confidence 0.46 Published 2008 Journal Yonsei Medical Journal Section Body Doc Link PMC2615285 Disease Relevance 0.30 Pain Relevance 0
Rapamycin is a specific inhibitor of mTOR function that prevents p70S6K and 4E-BPs phosphorylation thus interfering with the initiation of translation [11] of a subset of mRNAs rather than general translation [12].
Negative_regulation (prevents) of Phosphorylation (phosphorylation) of mTOR
3) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695538 Disease Relevance 0 Pain Relevance 0.12
The mTOR inhibitor rapamycin blocks the phosphorylation of 4E-BP1/2, S6K and S6 in skin
Negative_regulation (blocks) of Phosphorylation (phosphorylation) of mTOR in skin
4) Confidence 0.36 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2276314 Disease Relevance 0.06 Pain Relevance 0.34
The mTOR inhibitor rapamycin blocks the phosphorylation of 4E-BP1/2, S6K and S6 in skin
Negative_regulation (skin) of Phosphorylation (phosphorylation) of mTOR in skin
5) Confidence 0.36 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2276314 Disease Relevance 0.07 Pain Relevance 0.34
Furthermore, the reduction of AMPK and ACC phosphorylation and increase in phosphorylation of proteins involved in mTOR signal transduction, observed in the hypothalamus after leptin infusion, were more pronounced in both lean and diet-induced obesity rats after acute exercise.
Negative_regulation (reduction) of Phosphorylation (phosphorylation) of mTOR in hypothalamus associated with obesity
6) Confidence 0.31 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2585815 Disease Relevance 0.26 Pain Relevance 0.04
Furthermore, the reduction of AMPK and ACC phosphorylation and increase in phosphorylation of proteins involved in mTOR signal transduction, observed in the hypothalamus after leptin infusion, were more pronounced in both lean and diet-induced obesity rats after acute exercise.
Negative_regulation (reduction) of Phosphorylation (phosphorylation) of mTOR in hypothalamus associated with obesity
7) Confidence 0.31 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2585815 Disease Relevance 0.26 Pain Relevance 0.04
Paradoxically, these increases in Akt phosphorylation were associated with diminished mammalian target of rapamycin (mTOR) phosphorylation, along with decreased levels of insulin receptor beta (IR-?)
Negative_regulation (diminished) of Phosphorylation (phosphorylation) of mTOR
8) Confidence 0.28 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2712760 Disease Relevance 0.29 Pain Relevance 0.16
Interestingly, these data do not appear to predict down-stream Akt signaling since the phosphorylation level of mTOR (Ser2448) [9] (Figure 2A), tuberous sclerosis complex-2 (TSC2) and forkhead box O1 (FoxO1) (data not shown) was lower in the very aged muscle.
Negative_regulation (level) of Phosphorylation (phosphorylation) of mTOR in muscle associated with tuberous sclerosis
9) Confidence 0.28 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2712760 Disease Relevance 0.43 Pain Relevance 0.07

General Comments

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