INT228677

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Context Info
Confidence 0.51
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 24
Total Number 24
Disease Relevance 3.88
Pain Relevance 2.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Rps6kb1) mitochondrion (Rps6kb1) aging (Rps6kb1)
nucleus (Rps6kb1) cell cycle (Rps6kb1) cytoplasm (Rps6kb1)
Anatomy Link Frequency
skin 14
hypothalamus 4
dorsal 2
nerve 2
Rps6kb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
long-term potentiation 39 93.96 High High
Inflammatory response 10 87.72 High High
Sciatic nerve 50 85.48 High High
Calcitonin gene-related peptide 91 74.68 Quite High
withdrawal 146 67.64 Quite High
Hippocampus 101 66.08 Quite High
cytokine 14 65.12 Quite High
Gabapentin 1 59.32 Quite High
nociceptor 413 58.48 Quite High
agonist 7 56.20 Quite High
Disease Link Frequency Relevance Heat
Obesity 162 100.00 Very High Very High Very High
Neointima 11 91.96 High High
Injury 121 90.36 High High
Cancer 6 87.52 High High
INFLAMMATION 43 87.36 High High
Hypersensitivity 35 75.00 Quite High
Nociception 68 74.88 Quite High
Targeted Disruption 20 72.72 Quite High
Amnesia 12 70.84 Quite High
Vasculitis 2 69.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It was shown that rosiglitazone inhibits phosphorylation of the Akt-mTOR-P70S6K system in RAoSMCs stimulated with insulin.
Negative_regulation (inhibits) of Phosphorylation (phosphorylation) of mTOR-P70S6K
1) Confidence 0.51 Published 2008 Journal Yonsei Medical Journal Section Body Doc Link PMC2615285 Disease Relevance 1.03 Pain Relevance 0.03
Rapamycin is a specific inhibitor of mTOR function that prevents p70S6K and 4E-BPs phosphorylation thus interfering with the initiation of translation [11] of a subset of mRNAs rather than general translation [12].
Negative_regulation (prevents) of Phosphorylation (phosphorylation) of p70S6K
2) Confidence 0.49 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695538 Disease Relevance 0 Pain Relevance 0.12
We found that blockade of BDNF with function-blocking anti-BDNF antibodies delivered into dorsal CA1 15 min before training abolished the IA learning-induced increase in mTOR (Figure 5A) and p70S6K (Figure 5B) phosphorylation.
Negative_regulation (abolished) of Phosphorylation (phosphorylation) of p70S6K in dorsal
3) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695538 Disease Relevance 0 Pain Relevance 0.06
At the dose used in the pharmacological experiments presented above (4.3 pg/side), the intra-CA1 infusion of rapamycin inhibited hippocampal p70S6K phosphorylation by more than 60% (p<0.05, n?
Negative_regulation (inhibited) of Phosphorylation (phosphorylation) of p70S6K
4) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695538 Disease Relevance 0.07 Pain Relevance 0.03
Rapamycin is a specific inhibitor of mTOR function that prevents p70S6K and 4E-BPs phosphorylation thus interfering with the initiation of translation [11] of a subset of mRNAs rather than general translation [12].
Negative_regulation (interfering) of Phosphorylation (phosphorylation) of p70S6K
5) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695538 Disease Relevance 0 Pain Relevance 0.12
L dose respectively of rapamycin attenuate the phosphorylation of p70S6K.
Negative_regulation (attenuate) of Phosphorylation (phosphorylation) of p70S6K
6) Confidence 0.33 Published 2010 Journal The Journal of Pain Section Body Doc Link PMC3000494 Disease Relevance 0.51 Pain Relevance 0.09
Specifically, western blot analysis showed a significant decrease in 4E-BP1/2 and S6K phosphorylation in the skin 30 min after injection of rapamycin compared to vehicle (Fig. 3A, P<0.01 for both proteins).
Negative_regulation (decrease) of Phosphorylation (phosphorylation) of S6K in skin
7) Confidence 0.31 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2276314 Disease Relevance 0.09 Pain Relevance 0.07
There was a significant decrease in S6 phosphorylation in the rapamycin-treated group when compared to vehicle at 2 h after treatment but not at 30 min (Fig. 3A, drug effect: F1,8?
Negative_regulation (decrease) of Phosphorylation (phosphorylation) of S6
8) Confidence 0.31 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2276314 Disease Relevance 0.08 Pain Relevance 0.04
The mTOR inhibitor rapamycin blocks the phosphorylation of 4E-BP1/2, S6K and S6 in skin
Negative_regulation (blocks) of Phosphorylation (phosphorylation) of S6K in skin
9) Confidence 0.31 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2276314 Disease Relevance 0.06 Pain Relevance 0.33
In addition, p70S6K and 4EBP1 phosphorylation in the hypothalamus of DIO rats after i.c.v. leptin infusion was reduced by about 46% and 45%, respectively, when compared to the control group.
Negative_regulation (reduced) of Phosphorylation (phosphorylation) of p70S6K in hypothalamus associated with obesity
10) Confidence 0.30 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 1.05 Pain Relevance 0
If the effect of IL-6 on food intake is mediated by mTOR activation, Rapamycin infusion at doses that do not change food intake, but still decrease p70S6K and 4EBP1 phosphorylations could be sufficient to block the effects of IL-6.
Neg (not) Negative_regulation (decrease) of Phosphorylation (phosphorylations) of p70S6K
11) Confidence 0.30 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0.11 Pain Relevance 0
AICAR reduced p70S6K and 4EBP1 threonine phosphorylation levels in the hypothalamus of control and exercised rats.
Negative_regulation (reduced) of Phosphorylation (phosphorylation) of p70S6K in hypothalamus
12) Confidence 0.29 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0 Pain Relevance 0.03
Exercised animals pretreated with Rapamycin also reduced hypothalamic p70S6K and 4EBP1 phosphorylation (Figures 8d and e).
Negative_regulation (reduced) of Phosphorylation (phosphorylation) of p70S6K
13) Confidence 0.29 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0 Pain Relevance 0
The level of phosphorylation of S6 protein was also used as a measure of S6K activity [23], [32]–[34].
Negative_regulation (measure) of Phosphorylation (phosphorylation) of S6
14) Confidence 0.22 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2276314 Disease Relevance 0.08 Pain Relevance 0.31
The mTOR inhibitor rapamycin blocks the phosphorylation of 4E-BP1/2, S6K and S6 in skin
Negative_regulation (blocks) of Phosphorylation (phosphorylation) of S6K in skin
15) Confidence 0.22 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2276314 Disease Relevance 0.06 Pain Relevance 0.33
The mTOR inhibitor rapamycin blocks the phosphorylation of 4E-BP1/2, S6K and S6 in skin
Negative_regulation (skin) of Phosphorylation (phosphorylation) of S6 in skin
16) Confidence 0.22 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2276314 Disease Relevance 0.07 Pain Relevance 0.33
Activity of mTOR in the skin was assessed by quantifying phosphorylation of direct downstream targets 4E-BP1/2 and S6K.
Negative_regulation (quantifying) of Phosphorylation (phosphorylation) of S6K in skin
17) Confidence 0.22 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2276314 Disease Relevance 0.08 Pain Relevance 0.32
The mTOR inhibitor rapamycin blocks the phosphorylation of 4E-BP1/2, S6K and S6 in skin
Negative_regulation (blocks) of Phosphorylation (phosphorylation) of S6 in skin
18) Confidence 0.22 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2276314 Disease Relevance 0.07 Pain Relevance 0.33
The mTOR inhibitor rapamycin blocks the phosphorylation of 4E-BP1/2, S6K and S6 in skin
Negative_regulation (skin) of Phosphorylation (phosphorylation) of S6K in skin
19) Confidence 0.22 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2276314 Disease Relevance 0.07 Pain Relevance 0.33
A marked decrease in S6K phosphorylation was observed 30 min after rapamycin injection throughout the treated dermis, including nerve fibers, when compared to vehicle treatment.
Negative_regulation (decrease) of Phosphorylation (phosphorylation) of S6K in nerve
20) Confidence 0.22 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2276314 Disease Relevance 0.19 Pain Relevance 0.06

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