INT22871

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Context Info
Confidence 0.68
First Reported 1990
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 30
Total Number 31
Disease Relevance 14.86
Pain Relevance 1.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (ELN) extracellular region (ELN) proteinaceous extracellular matrix (ELN)
Anatomy Link Frequency
lung 6
extracellular matrix 2
alveolar walls 2
sputum 1
myometrium 1
ELN (Homo sapiens)
Pain Link Frequency Relevance Heat
Neurobehavioral 6 100.00 Very High Very High Very High
metalloproteinase 12 99.66 Very High Very High Very High
fibrosis 9 97.52 Very High Very High Very High
cytokine 34 95.88 Very High Very High Very High
cva 12 94.56 High High
pruritus 2 93.20 High High
carpal tunnel syndrome 2 90.72 High High
Inflammation 123 90.32 High High
Restless leg syndrome 1 90.04 High High
Snapping jaw 1 75.00 Quite High
Disease Link Frequency Relevance Heat
Williams-beuren Syndrome 28 100.00 Very High Very High Very High
Disease 263 99.96 Very High Very High Very High
Emphysema 420 99.84 Very High Very High Very High
Adhesions 17 99.42 Very High Very High Very High
Age-related Macular Degeneration 64 99.26 Very High Very High Very High
Anaemia 3 98.52 Very High Very High Very High
Acrodermatitis 4 97.98 Very High Very High Very High
Pulmonary Disease 140 97.52 Very High Very High Very High
Fibrosis 16 97.52 Very High Very High Very High
Nutritional Deficiencies 28 96.62 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSION: The distribution of elastin may help explain the normal function of the myometrium in labor.
Gene_expression (distribution) of elastin in myometrium
1) Confidence 0.68 Published 2006 Journal Anal. Quant. Cytol. Histol. Section Body Doc Link 16637515 Disease Relevance 0.23 Pain Relevance 0
The adventitia showed an increase in elastin fibres in all cases.
Gene_expression (fibres) of elastin
2) Confidence 0.65 Published 1990 Journal Br J Surg Section Abstract Doc Link 2340387 Disease Relevance 0.45 Pain Relevance 0.14
Dermatitis, alopecia, and nail defects are also associated with zinc deficiency.[4] Acrodermatitis enteropathica develops in a zinc-deficient patient and a combined nutritional deficiency of zinc, EFAs, albumin and amino acids may result in acrodermatitis enteropathica.[14] The activities of lysyl oxidases that initiate the cross-linking of collagen and elastin decline with copper deficiency.[15] Chronic iron deficiency has resulted in spoon shaped nails (koilonychia), hair loss, glossitis with loss of papillae, angular cheilitis, and pruritus.[4]
Gene_expression (decline) of elastin in angular associated with skin appendage disease, glossitis, acrodermatitis, nutritional deficiencies, eczema, anaemia, pruritus, cheilitis and alopecia
3) Confidence 0.65 Published 2010 Journal Indian Journal of Dermatology Section Body Doc Link PMC2965901 Disease Relevance 2.14 Pain Relevance 0.15
Elastin was found in the upper and lower strata of the retrodiscal tissues, as well as in the central zone.
Gene_expression (found) of Elastin in upper
4) Confidence 0.60 Published 1994 Journal J Orofac Pain Section Abstract Doc Link 8032333 Disease Relevance 0.16 Pain Relevance 0.07
No elastin was present within leiomyomas, adenomyomas or adenomyosis.
Neg (No) Gene_expression (present) of elastin
5) Confidence 0.60 Published 2006 Journal Anal. Quant. Cytol. Histol. Section Body Doc Link 16637515 Disease Relevance 0.24 Pain Relevance 0
However, data obtained in a different model of alveolar depletion, elastase-induced emphysema, indicate that cigarette smoke exposure may indeed induce a defect in elastin synthesis and cross-linking, alveolar growth, multiplication and/or repair.
Gene_expression (synthesis) of elastin associated with emphysema
6) Confidence 0.45 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2699955 Disease Relevance 0.16 Pain Relevance 0
Elastin in particular is an essential component of the alveolar extracellular matrix as it provides the lung with the elasticity needed for ventilation, and it is probable that elastin synthesis is an essential step in alveolar growth and regeneration.
Gene_expression (synthesis) of elastin in lung
7) Confidence 0.45 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2699955 Disease Relevance 0.08 Pain Relevance 0
Indeed, while elastase instillation in the trachea induces a sharp elevation in elastin synthesis in the lung, this response is reduced by 40% in the lung of hamsters exposed to cigarette smoke for one week (Osman et al 1985).
Gene_expression (synthesis) of elastin in lung
8) Confidence 0.45 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2699955 Disease Relevance 0.22 Pain Relevance 0
In this study, the localization of lung elastin mRNA expression after pneumonectomy differed slightly from that observed in developing animals as in the latter case elastin mRNA expression was observed at the end and bend of alveolar walls but was not observed at the junctions of alveolar walls.
Gene_expression (expression) of elastin mRNA in alveolar walls
9) Confidence 0.45 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2699955 Disease Relevance 0.09 Pain Relevance 0
For instance, contrary to what is observed in the normal lung (Shapiro et al 1991), a high elastin turnover is observed in the emphysematous lung (Stone et al 1995; Gottlieb et al 1996; Vlahovic et al 1999), indicating that in parallel with the excessive degradation of elastic fibers which is observed in this disease, elastin synthesis occurs in the lung.
Gene_expression (synthesis) of elastin in lung associated with disease
10) Confidence 0.45 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2699955 Disease Relevance 0.58 Pain Relevance 0
In this study, the localization of lung elastin mRNA expression after pneumonectomy differed slightly from that observed in developing animals as in the latter case elastin mRNA expression was observed at the end and bend of alveolar walls but was not observed at the junctions of alveolar walls.
Gene_expression (expression) of elastin mRNA in alveolar walls
11) Confidence 0.45 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2699955 Disease Relevance 0.09 Pain Relevance 0
In particular, elastin synthesis and cross-linking seem to be especially sensitive to exposure to cigarette smoke.
Gene_expression (synthesis) of elastin
12) Confidence 0.45 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2699955 Disease Relevance 0.12 Pain Relevance 0
This reduction in elastin synthesis is accompanied by a seven-fold reduction in lysyl oxidase activity in the lung of those animals.
Gene_expression (synthesis) of elastin in lung
13) Confidence 0.40 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2699955 Disease Relevance 0.29 Pain Relevance 0
This reduction in elastin synthesis and cross-linking may be of great pathophysiological significance as emphysema lesions are exaggerated in hamsters exposed to cigarette smoke after elastase instillation (Hoidal and Niewoehner 1983).


Gene_expression (synthesis) of elastin associated with emphysema
14) Confidence 0.40 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2699955 Disease Relevance 0.38 Pain Relevance 0
Pulmonary fibroblasts are the main cell type responsible for the synthesis and secretion of the main components of the alveolar extracellular matrix, proteoglycan, collagen and elastin.
Gene_expression (synthesis) of elastin in extracellular matrix
15) Confidence 0.40 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2699955 Disease Relevance 0.06 Pain Relevance 0
In an acellular model, cigarette smoke inhibits elastin cross-linking (Laurent et al 1983), while the transcription of lysyl oxidase, a key effector of elastin cross-linking is reduced in fetal rat lung fibroblasts exposed to cigarette smoke extract (Gao et al 2005).
Gene_expression (cross) of elastin in lung
16) Confidence 0.39 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2699955 Disease Relevance 0.12 Pain Relevance 0
Supporting this hypothesis, Koh and colleagues (Koh et al 1996) showed that tropoelastin mRNA was sharply overexpressed in the lung of rats after pneumonectomy, and that its expression was localized to the ends, bends and junctions of alveolar walls, indicating that the de novo synthesis of elastic fibers was part of the process of alveolar growth and multiplication.
Gene_expression (overexpressed) of tropoelastin mRNA in lung associated with decompression sickness
17) Confidence 0.35 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2699955 Disease Relevance 0.10 Pain Relevance 0
Type VI was primarily located in microfibrillar structures between collagen bundles, between elastin and collagen bundles and between collagen bundles and cells.
Gene_expression (bundles) of elastin
18) Confidence 0.35 Published 2005 Journal J. Orthop. Res. Section Abstract Doc Link 15921875 Disease Relevance 0.41 Pain Relevance 0.09
Type VI was primarily located in microfibrillar structures between collagen bundles, between elastin and collagen bundles and between collagen bundles and cells.
Gene_expression (bundles) of elastin
19) Confidence 0.35 Published 2005 Journal J. Orthop. Res. Section Abstract Doc Link 15921875 Disease Relevance 0.41 Pain Relevance 0.09
Males also expressed higher activities of genes promoting cell adhesion (cell adhesion molecule 1 and claudin 16), elastin deposition in the extracellular matrix (lysyl oxidase-like 1), mucin-type O-linked glycosylation (UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 6), thyroid hormone inactivation (Type III iodothyronine deiodinase), lysophospholipid hydrolysis (ectonucleotide pyrophosphatase/ phosphodiesterase 2) and neurite outgrowth and arborization (neuritin 1).
Gene_expression (deposition) of elastin in extracellular matrix associated with adhesions
20) Confidence 0.23 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2790476 Disease Relevance 0.31 Pain Relevance 0

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