INT228727

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Context Info
Confidence 0.27
First Reported 2008
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 5.13
Pain Relevance 0.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il5) extracellular region (Il5)
Anatomy Link Frequency
eosinophil 1
Il5 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 88 99.66 Very High Very High Very High
Inflammation 90 98.84 Very High Very High Very High
corticosteroid 10 82.48 Quite High
agonist 4 31.76 Quite Low
Nerve growth factor 2 31.48 Quite Low
lidocaine 6 17.84 Low Low
chemokine 11 15.56 Low Low
Inflammatory response 6 12.56 Low Low
fibrosis 3 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rhinitis 30 99.26 Very High Very High Very High
INFLAMMATION 94 98.84 Very High Very High Very High
Eosinophilic Esophagitis 16 98.76 Very High Very High Very High
Hypersensitivity 42 97.16 Very High Very High Very High
Eosinophilia 34 96.60 Very High Very High Very High
Apoptosis 154 93.60 High High
Asthma 90 91.96 High High
Disease 53 86.68 High High
Increased Venous Pressure Under Development 3 80.04 Quite High
Pulmonary Disease 1 78.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
inflammation such as eosinophilic, lymphocytic infiltration, and mRNA expression for IL-4 and IL-5 [23].
Transcription (expression) of IL-5 associated with rhinitis and inflammation
1) Confidence 0.27 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2276601 Disease Relevance 2.17 Pain Relevance 0.52
Expression of mRNA for murine IL-4, IL-5, IL-6, IL-33 and ST2 were determined using commercially available FAM-labeled Taqman primers and probes (Applied Biosystems) on cDNA derived from mRNA extracted using a Qiagen RNeasy mRNA isolation kit.
Spec (determined) Transcription (Expression) of IL-5
2) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2914748 Disease Relevance 0.15 Pain Relevance 0
It is now clear that glucocorticoids suppress the transcription of the IL-5 and other cytokine genes.
Transcription (transcription) of IL-5 associated with cytokine
3) Confidence 0.10 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2846745 Disease Relevance 1.00 Pain Relevance 0.30
A minimum of 15 eosinophils per high power field is now used as pathological criteria for EE.64 Murine models have demonstrated that IL-5 maintains the systemic eosinophil levels needed for esophageal eosinophilia accumulation.16 Substantial evidence is accumulating that human EE is also associated with a Th2 type immune response and local or systemic Th2 cytokine overproduction; IL-5 mRNA expression is induced in the biopsies of EE patients compared to healthy controls,65 and anti-IL-5 may be effective in some but not all patients with EE.66, 67 In human EE, eotaxin-3 (CCL26) expression strongly correlates with eosinophil numbers.68
Transcription (expression) of IL-5 in eosinophil associated with eosinophilia, eosinophilic esophagitis and cytokine
4) Confidence 0.10 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2846745 Disease Relevance 1.81 Pain Relevance 0.08

General Comments

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