INT22873

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Context Info
Confidence 0.45
First Reported 1990
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 3.74
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (ELN) extracellular region (ELN) proteinaceous extracellular matrix (ELN)
ELN (Homo sapiens)
Pain Link Frequency Relevance Heat
fibrosis 3 98.00 Very High Very High Very High
Restless leg syndrome 1 90.52 High High
Inflammation 54 70.32 Quite High
chemokine 2 69.12 Quite High
ischemia 1 60.36 Quite High
lumbar region 2 54.40 Quite High
Serotonin 9 50.00 Quite Low
Bioavailability 3 45.12 Quite Low
metalloproteinase 1 43.28 Quite Low
Inflammatory mediators 1 36.96 Quite Low
Disease Link Frequency Relevance Heat
Williams-beuren Syndrome 27 100.00 Very High Very High Very High
Injury 108 98.96 Very High Very High Very High
Fibrosis 7 98.00 Very High Very High Very High
Cognitive Disorder 3 96.72 Very High Very High Very High
Viral Meningitis 42 96.04 Very High Very High Very High
Intellectual Impairment 1 95.80 Very High Very High Very High
Hypertension 2 95.60 Very High Very High Very High
Wound Healing 42 93.48 High High
Pressure Volume 2 Under Development 1 92.96 High High
Left Ventricular Hypertrophy 1 92.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The adventitia showed an increase in elastin fibres in all cases.
Positive_regulation (increase) of elastin
1) Confidence 0.45 Published 1990 Journal Br J Surg Section Abstract Doc Link 2340387 Disease Relevance 0.45 Pain Relevance 0.14
Arteries become wider and less elastic (increased PWV) with advancing age as a consequence of the age-related reduction in arterial elastin and increase in collagen content [16].
Positive_regulation (increase) of elastin
2) Confidence 0.18 Published 2010 Journal The Open Cardiovascular Medicine Journal Section Body Doc Link PMC2847817 Disease Relevance 0.61 Pain Relevance 0.06
Additionally, both proteases degraded elastin (a major constituent of elastic fibers) in the zymographic assays, indicating that proteases from AGE isolate exhibit elastinolytic activities (Fig. 5).
Positive_regulation (proteases) of elastin associated with viral meningitis
3) Confidence 0.08 Published 2006 Journal BMC Microbiol Section Body Doc Link PMC1464133 Disease Relevance 0.30 Pain Relevance 0
WBS is caused by a common hemizygous deletion of less than 30 genes on chromosome 7, providing the opportunity to study correlations between genes, physiology and social behavior.
Positive_regulation (caused) of WBS associated with williams-beuren syndrome
4) Confidence 0.01 Published 2010 Journal J Neurodev Disord Section Body Doc Link PMC2882561 Disease Relevance 0.76 Pain Relevance 0
Increase in WBS and role of antioxidants were experimentally proved by Michel and Fredrickson (24).
Positive_regulation (Increase) of WBS
5) Confidence 0.01 Published 2008 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2249741 Disease Relevance 0.92 Pain Relevance 0.10
WBS was significantly increased in the O. sanctum-treated group compared with control with both the extracts and with both the doses.
Positive_regulation (increased) of WBS
6) Confidence 0.01 Published 2008 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2249741 Disease Relevance 0.70 Pain Relevance 0.03

General Comments

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