INT22875

Context Info Confidence 0.39 First Reported 1987 Last Reported 2011 Negated 2 Speculated 1 Reported most in Body Documents 16 Total Number 17 Disease Relevance 14.33 Pain Relevance 2.69

Anatomy Link Frequency deep cerebellar nucleus 1 blood 1 lung 1 respiratory 1 CRS (Homo sapiens)

Pain Link Frequency Relevance Heat Sciatica 8 99.32 Inflammation 149 98.92 adenocard 14 95.56 metalloproteinase 3 95.12 Action potential 2 94.12 cytokine 13 93.20 corticosteroid 6 91.48 Inflammatory marker 3 87.04 qutenza 9 84.40 Catecholamine 1 78.72

Disease Link Frequency Relevance Heat Chronic Sinusitis 455 100.00 Syndrome 59 100.00 Disease 125 99.76 Paralysis 3 99.72 Hypersensitivity 60 99.58 Nerve Root Compression 8 99.32 Myocardial Infarction 43 99.12 INFLAMMATION 157 98.92 Lower Respiratory Tract Infection 1 98.40 Nicotine Addiction 16 98.08

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

A 2008 Working Group on CRS in Adults, supported by the American Academy of Otolaryngic Allergy (AAOA), developed a series of algorithms for the differential diagnosis and treatment of CRS in adults, based on the evolving understanding of CRS as an inflammatory disease.

Regulation (series) of CRS associated with inflammation, chronic sinusitis, hypersensitivity and disease

1) Confidence 0.39 Published 2009 Journal Postgrad Med Section Abstract Doc Link 19940423 Disease Relevance 1.88 Pain Relevance 0.25

Finally, there exists no report on immunomodulating agents in CRS.

Regulation (immunomodulating) of CRS associated with chronic sinusitis

2) Confidence 0.32 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1936288 Disease Relevance 0.99 Pain Relevance 0.21

Finally, there exists no report on immunomodulating agents in CRS.

Neg (no) Regulation (report) of CRS associated with chronic sinusitis

3) Confidence 0.32 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1936288 Disease Relevance 0.99 Pain Relevance 0.21

On the other hand CysLT1 and CysLT2 mRNA levels were similar in CRS and normal mucosa, however significantly higher concentrations of CysLT1 compared to CysLT2 were observed in the CRS-NP group.

Regulation (similar) of CRS

4) Confidence 0.28 Published 2006 Journal Respir Res Section Body Doc Link PMC1481584 Disease Relevance 0.31 Pain Relevance 0.08

The other simple clinical methods using a combination of changes in Crs, PaO2 and PCO2, or in EELV, do only evaluate a posteriori whether an LRM combined with high PEEP has been effective [13].

Regulation (changes) of Crs

5) Confidence 0.23 Published 2008 Journal Crit Care Section Body Doc Link PMC2374591 Disease Relevance 0.20 Pain Relevance 0

Compared with values obtained during SB, there was no significant change in Crs after paralysis when ventilation matched the child's own pattern (P greater than 0.2).

Neg (no) Regulation (change) of Crs associated with paralysis

6) Confidence 0.23 Published 1990 Journal J. Appl. Physiol. Section Abstract Doc Link 2341337 Disease Relevance 0.27 Pain Relevance 0.08

The inclusion criteria were no current symptoms of respiratory disease, no respiratory infection in the preceding 2 weeks, no allergic disease, and no other disease that could modulate CRS.

Regulation (modulate) of CRS in respiratory associated with hypersensitivity, lower respiratory tract infection, disease and respiratory disease

7) Confidence 0.23 Published 2008 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 19218699 Disease Relevance 1.06 Pain Relevance 0.23

Of 16 patients with symptoms but no signs of radiculopathy, EMG was abnormal in 5 (31%) and CRS was abnormal in 9 (56%).

Regulation (abnormal) of CRS associated with sciatica

8) Confidence 0.23 Published 1987 Journal Neurology Section Abstract Doc Link 3808317 Disease Relevance 0.35 Pain Relevance 0.40

In 18 patients with clinical evidence of radiculopathy, EMG was abnormal in 11 (61%), but CRS was abnormal in all 18.

Regulation (abnormal) of CRS associated with sciatica

9) Confidence 0.23 Published 1987 Journal Neurology Section Abstract Doc Link 3808317 Disease Relevance 0.36 Pain Relevance 0.41

Other non inflammatory parameters have been suspected to induce or at least participate in the CRS evolution.

Regulation (participate) of CRS associated with inflammation and chronic sinusitis

10) Confidence 0.19 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1936288 Disease Relevance 2.02 Pain Relevance 0.33

This pathway might be very attractive as a contemporary therapeutic target in CRS [14].

Regulation (target) of CRS associated with syndrome

11) Confidence 0.16 Published 2011 Journal International Journal of Nephrology Section Body Doc Link PMC3010630 Disease Relevance 1.10 Pain Relevance 0.23

To our knowledge, the present study is the largest of its type to report on the correlation of SA exotoxin genes in CRS with and without NP.

Regulation (report) of CRS associated with chronic sinusitis

12) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2832699 Disease Relevance 0.87 Pain Relevance 0.04

Patients reported blood relatives affected with CRS in 37.7% of instances.

Regulation (affected) of CRS in blood associated with chronic sinusitis

13) Confidence 0.03 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2292155 Disease Relevance 0.89 Pain Relevance 0.05

Finally, we examined the effect on CRs of removing the threshold non-linearity introduced in the model of the deep cerebellar nucleus.

Spec (examined) Regulation (effect) of CRs in deep cerebellar nucleus

14) Confidence 0.02 Published 2010 Journal Frontiers in Computational Neuroscience Section Body Doc Link PMC2965015 Disease Relevance 0 Pain Relevance 0

The goal of this study was to evaluate the effect of single nucleotide polymorphisms (SNP) on CRS in a panel of genes related to cysteinyl leukotriene metabolism.

Regulation (effect) of CRS associated with chronic sinusitis

15) Confidence 0.02 Published 2008 Journal BMC Med Genet Section Abstract Doc Link PMC2292155 Disease Relevance 0.64 Pain Relevance 0.04

Furthermore it has been shown in both adults [75,76] and children [77] that inspiratory flow (which influences lung deposition) influences CRS.

Regulation (influences) of CRS in lung

16) Confidence 0.02 Published 2005 Journal Cough Section Body Doc Link PMC1277009 Disease Relevance 1.16 Pain Relevance 0.06

In children, CRS is instead influenced by airway calibre and age [44].

Regulation (influenced) of CRS

17) Confidence 0.02 Published 2005 Journal Cough Section Body Doc Link PMC1277009 Disease Relevance 1.25 Pain Relevance 0.07

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