INT228770

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Context Info
Confidence 0.57
First Reported 2006
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 16
Total Number 16
Disease Relevance 21.49
Pain Relevance 1.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
Eye 2
fovea 2
brain 1
vessels 1
epithelium 1
amd (Mus musculus)
Pain Link Frequency Relevance Heat
corticosteroid 1 100.00 Very High Very High Very High
Inflammation 268 98.48 Very High Very High Very High
Central nervous system 7 97.40 Very High Very High Very High
agonist 75 97.28 Very High Very High Very High
cva 93 92.04 High High
ischemia 23 85.12 High High
Neuritis 30 60.64 Quite High
cytokine 27 58.36 Quite High
Hippocampus 35 53.80 Quite High
Multiple sclerosis 29 49.76 Quite Low
Disease Link Frequency Relevance Heat
Age-related Macular Degeneration 1643 100.00 Very High Very High Very High
Diabetic Retinopathy 101 100.00 Very High Very High Very High
Nicotine Addiction 106 99.70 Very High Very High Very High
Uveitis 16 99.32 Very High Very High Very High
Disease 144 98.76 Very High Very High Very High
INFLAMMATION 290 98.48 Very High Very High Very High
Diabetes Mellitus 147 97.92 Very High Very High Very High
Diabetic Macular Edema 1 95.96 Very High Very High Very High
Eye Disease 28 95.84 Very High Very High Very High
Ocular Toxicity (including Many Sub-types) 283 94.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The epidemiologic data, such as the Beaver Dam Eye Study, suggest that smoking induces early AMD as well as progression of AMD, compared to nonsmokers [32].
Gene_expression (progression) of AMD in Eye associated with nicotine addiction and age-related macular degeneration
1) Confidence 0.57 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2518621 Disease Relevance 1.95 Pain Relevance 0
The epidemiologic data, such as the Beaver Dam Eye Study, suggest that smoking induces early AMD as well as progression of AMD, compared to nonsmokers [32].
Gene_expression (progression) of AMD in Eye associated with nicotine addiction and age-related macular degeneration
2) Confidence 0.57 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2518621 Disease Relevance 1.95 Pain Relevance 0
Two anti-VEGF therapies for AMD are FDA approved, with others in various stages of development.
Gene_expression (therapies) of AMD associated with age-related macular degeneration
3) Confidence 0.54 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012443 Disease Relevance 0.89 Pain Relevance 0
Neovascular AMD, also known as “wet AMD” or “exudative AMDmakes up about 15% of total AMD cases (Haddad et al. 2006) and is characterized by choroidal neovascularization (CNV), usually involving the fovea (Nowak 2006).
Gene_expression (makes) of AMD in fovea associated with age-related macular degeneration
4) Confidence 0.54 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012443 Disease Relevance 2.26 Pain Relevance 0.03
Neovascular AMD, also known as “wet AMD” or “exudative AMDmakes up about 15% of total AMD cases (Haddad et al. 2006) and is characterized by choroidal neovascularization (CNV), usually involving the fovea (Nowak 2006).
Gene_expression (makes) of AMD in fovea associated with age-related macular degeneration
5) Confidence 0.54 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012443 Disease Relevance 2.23 Pain Relevance 0.03
Dry AMD accounts for approximately 85% of total AMD cases (Haddad et al. 2006) and is characterized by off-white to yellow subretinal deposits called drusen and/or retinal pigment epithelium (RPE) irregularities.
Gene_expression (accounts) of AMD in epithelium associated with ocular toxicity (including many sub-types) and age-related macular degeneration
6) Confidence 0.54 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012443 Disease Relevance 1.96 Pain Relevance 0
Unmet needs in neovascular AMD
Gene_expression (needs) of AMD associated with age-related macular degeneration
7) Confidence 0.54 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012443 Disease Relevance 1.08 Pain Relevance 0
The primary outcome measure was late AMD, or each type of late AMD if the overall results for late AMD were not presented.


Neg (not) Gene_expression (presented) of AMD associated with age-related macular degeneration
8) Confidence 0.35 Published 2010 Journal BMC Ophthalmol Section Body Doc Link PMC3009619 Disease Relevance 0.74 Pain Relevance 0
The primary outcome measure was late AMD, or each type of late AMD if the overall results for late AMD were not presented.


Neg (not) Gene_expression (presented) of AMD associated with age-related macular degeneration
9) Confidence 0.31 Published 2010 Journal BMC Ophthalmol Section Body Doc Link PMC3009619 Disease Relevance 0.81 Pain Relevance 0
Pegaptanib or other anti-VEGF therapies were most effective against AMD in the early stages and were not particularly effective against the more established vessels.
Gene_expression (effective) of AMD in vessels associated with age-related macular degeneration
10) Confidence 0.20 Published 2006 Journal International Journal of Nanomedicine Section Body Doc Link PMC2426796 Disease Relevance 0.76 Pain Relevance 0
infiltrating macrophages and/or resident microglia in the pathogenesis of AMD
Gene_expression (pathogenesis) of AMD in microglia associated with age-related macular degeneration
11) Confidence 0.13 Published 2008 Journal PPAR Research Section Body Doc Link PMC2276614 Disease Relevance 0.69 Pain Relevance 0.19
macular degeneration (AMD) and autoimmune uveitis, conditions that are very far
Gene_expression (degeneration) of AMD associated with uveitis and age-related macular degeneration
12) Confidence 0.13 Published 2008 Journal PPAR Research Section Body Doc Link PMC2276614 Disease Relevance 1.97 Pain Relevance 0.40
PPARs in AMD has been mainly focused on their activities as modulators of
Gene_expression (focused) of AMD associated with age-related macular degeneration
13) Confidence 0.12 Published 2008 Journal PPAR Research Section Body Doc Link PMC2276614 Disease Relevance 0.86 Pain Relevance 0.18
PDT combined with Macugen (sponsored by Novartis/ QLT under Peter Kaiser).NAPP study (Neovascular AMD, peri-ocular corticosteroids and PDT trial)
Gene_expression (trial) of AMD associated with corticosteroid and age-related macular degeneration
14) Confidence 0.08 Published 2007 Journal Indian Journal of Ophthalmology Section Body Doc Link PMC2635983 Disease Relevance 0.30 Pain Relevance 0.05
Previous studies showed that AMD3100 crosses the blood-brain barrier and exerts physiological effects in the CNS [41].
Gene_expression (crosses) of AMD3100 in brain associated with central nervous system
15) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013129 Disease Relevance 0.96 Pain Relevance 0.08
Second, the key pathogenic process in neovascular AMD and proliferative retinopathy is an increased expression of VEGFs.
Gene_expression (expression) of AMD associated with diabetic retinopathy and age-related macular degeneration
16) Confidence 0.05 Published 2008 Journal Diabetes Care Section Body Doc Link PMC2518369 Disease Relevance 2.06 Pain Relevance 0.10

General Comments

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