INT228772

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Context Info
Confidence 0.48
First Reported 2008
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 4.23
Pain Relevance 1.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ccl2) extracellular region (Ccl2) cytoskeleton organization (Ccl2)
cytoplasm (Ccl2)
Anatomy Link Frequency
macrophages 4
microglia 2
Ccl2 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 2 98.52 Very High Very High Very High
Inflammation 134 96.12 Very High Very High Very High
chemokine 20 94.72 High High
Spinal cord 46 88.88 High High
Dorsal horn neuron 4 85.00 Quite High
Inflammatory mediators 7 81.68 Quite High
long-term potentiation 13 75.28 Quite High
Central nervous system 6 72.96 Quite High
cytokine 16 72.00 Quite High
Inflammatory response 17 71.40 Quite High
Disease Link Frequency Relevance Heat
Obesity 93 100.00 Very High Very High Very High
Pain 2 98.52 Very High Very High Very High
Age-related Macular Degeneration 36 96.92 Very High Very High Very High
INFLAMMATION 150 96.12 Very High Very High Very High
Aids-related Complex 71 95.04 Very High Very High Very High
Nervous System Injury 16 85.76 High High
Cancer 18 80.88 Quite High
Necrosis 4 77.68 Quite High
Ocular Toxicity (including Many Sub-types) 6 65.76 Quite High
Occupational Lung Diseases 1 59.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
, CSF3R) and macrophage recruitment (CCL2) and/or perhaps a tissue remodeling response through activation of MMP9.
Positive_regulation (activation) of Localization (recruitment) of CCL2 in macrophage
1) Confidence 0.48 Published 2010 Journal Respir Res Section Body Doc Link PMC2892448 Disease Relevance 0.84 Pain Relevance 0.07
In this study, we didn't find any enhanced motility of microglia after local application of MCP-1, FKN, BDNF, NGF, IL-1?
Spec (find) Positive_regulation (find) of Localization (application) of MCP-1 in microglia
2) Confidence 0.37 Published 2010 Journal Mol Pain Section Body Doc Link PMC2857828 Disease Relevance 0.18 Pain Relevance 0.63
The latter factors can induce the secretion of IL-8 and MCP-1 in RPE cells in vitro

[120, 121].

Positive_regulation (induce) of Localization (secretion) of MCP-1
3) Confidence 0.33 Published 2008 Journal PPAR Research Section Body Doc Link PMC2276614 Disease Relevance 0.84 Pain Relevance 0.18
The level of MCP-1 released by adipocytes is significantly greater in obese mice than in nonobese mice [8–10] and is markedly increased when adipocytes are cocultured with macrophages [11, 12].
Positive_regulation (increased) of Localization (released) of MCP-1 in macrophages associated with obesity
4) Confidence 0.05 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2876247 Disease Relevance 2.36 Pain Relevance 0.33

General Comments

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