INT228790

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Context Info
Confidence 0.41
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.58
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Smad7) plasma membrane (Smad7) nucleus (Smad7)
intracellular (Smad7) protein complex (Smad7) cytoplasm (Smad7)
Smad7 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 25 86.64 High High
cytokine 11 65.12 Quite High
imagery 4 26.12 Quite Low
fibrosis 7 5.00 Very Low Very Low Very Low
cINOD 3 5.00 Very Low Very Low Very Low
chemokine 3 5.00 Very Low Very Low Very Low
Glutamate receptor 3 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 28 86.64 High High
Repression 3 82.60 Quite High
Keloid Scars 4 75.60 Quite High
Burns 10 74.96 Quite High
Stress 6 73.76 Quite High
Apoptosis 18 59.76 Quite High
Cancer 16 50.00 Quite Low
Fibrosis 8 5.00 Very Low Very Low Very Low
Dna Damage 3 5.00 Very Low Very Low Very Low
Chromosome Aberrations 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
observation was the induction of MADH7 in all the cell lines exposed to
Positive_regulation (induction) of MADH7
1) Confidence 0.41 Published 2008 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2276817 Disease Relevance 0.13 Pain Relevance 0.06
Thus, we postulate that suppression of myofibroblasts by TSA is due to the suppression of Smad activity by the upregulation of Smad7 and TGIF and inhibition of extracellular deposition of fibronectin.
Positive_regulation (upregulation) of Smad7
2) Confidence 0.30 Published 2010 Journal Molecular Vision Section Body Doc Link PMC3013068 Disease Relevance 0.31 Pain Relevance 0.08
The most prominent gene induction was seen for MADH7,
Positive_regulation (induction) of MADH7
3) Confidence 0.27 Published 2008 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2276817 Disease Relevance 0 Pain Relevance 0
MADH7 was upregulated at 8 hours, and its expression level
Positive_regulation (upregulated) of MADH7
4) Confidence 0.27 Published 2008 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2276817 Disease Relevance 0.14 Pain Relevance 0

General Comments

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