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Context Info
Confidence 0.37
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.87
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Gja1) Golgi apparatus (Gja1) transmembrane transport (Gja1)
cell-cell signaling (Gja1) cytoplasm (Gja1) signal transducer activity (Gja1)
Anatomy Link Frequency
cardiomyocytes 2
ependymal cells 2
heart 2
Gja1 (Mus musculus)
Pain Link Frequency Relevance Heat
Action potential 17 58.88 Quite High
Hippocampus 2 10.64 Low Low
action potential duration 20 5.00 Very Low Very Low Very Low
Spinal cord 9 5.00 Very Low Very Low Very Low
Central nervous system 8 5.00 Very Low Very Low Very Low
Peripheral nervous system 8 5.00 Very Low Very Low Very Low
cva 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
sodium channel 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Arrhythmogenic Right Ventricular Dysplasia 1 85.52 High High
Myocardial Infarction 14 78.64 Quite High
Autism 8 78.44 Quite High
Targeted Disruption 11 72.04 Quite High
Cancer 17 68.36 Quite High
Cerebral Edema 8 67.12 Quite High
Injury 19 63.56 Quite High
Infection 2 59.84 Quite High
Disease 2 55.32 Quite High
Epilepsy 5 5.24 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Decreased connexin43 expression in the mouse heart potentiates pacing-induced remodeling of repolarizing currents

Gap junction redistribution and reduced expression, a phenomenon termed gap junction remodeling (GJR), is often seen in diseased hearts and may predispose toward arrhythmias.

Negative_regulation (Decreased) of Gene_expression (expression) of connexin43 in heart
1) Confidence 0.37 Published 2008 Journal American Journal of Physiology - Heart and Circulatory Physiology Section Title Doc Link PMC2614590 Disease Relevance 0.07 Pain Relevance 0.03
Conceivably, more efficient cardiogenic differentiation within the environment of infracted heart may have yielded higher Connexin 43 expression and maturation of ion currents in engrafted cardiomyocytes resulting in improved functional in vivo integration.
Negative_regulation (yielded) of Gene_expression (expression) of Connexin 43 in cardiomyocytes
2) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2902505 Disease Relevance 0.29 Pain Relevance 0
The expression of connexin43 after exposure to IR has shown to vary in
Negative_regulation (vary) of Gene_expression (expression) of connexin43
3) Confidence 0.03 Published 2008 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2276817 Disease Relevance 0.07 Pain Relevance 0
Immunohistochemistry and electromicroscopy demonstrated that AQP4 deletion resulted in decreased expression of gap junction protein connexin43 (Cx43) [41], that is the main gap-junction protein in astrocytes as well as ependymal cells [77].
Negative_regulation (decreased) of Gene_expression (expression) of junction protein connexin43 in ependymal cells
4) Confidence 0.02 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923371 Disease Relevance 0.44 Pain Relevance 0

General Comments

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