INT22882

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Context Info
Confidence 0.57
First Reported 1990
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 11
Disease Relevance 5.19
Pain Relevance 0.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IMPA1) mitochondrion (IMPA1) nucleolus (IMPA1)
nucleus (IMPA1) cytoplasm (IMPA1)
Anatomy Link Frequency
muscle 1
IMPA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
carbamazepine 2 99.48 Very High Very High Very High
corticosteroid 3 85.56 High High
ischemia 12 74.48 Quite High
fibrosis 18 69.08 Quite High
cva 1 57.28 Quite High
abdominal pain 1 50.16 Quite High
Inflammation 29 50.00 Quite Low
backache 2 50.00 Quite Low
anesthesia 24 48.64 Quite Low
Morphine 12 36.48 Quite Low
Disease Link Frequency Relevance Heat
Arthritis 25 100.00 Very High Very High Very High
Myocardial Infarction 48 99.58 Very High Very High Very High
Coronary Heart Disease 24 98.86 Very High Very High Very High
Dilated Cardiomyopathy 36 98.44 Very High Very High Very High
Polyuria 1 98.02 Very High Very High Very High
Heart Rate Under Development 6 97.12 Very High Very High Very High
Mitral Valve Insufficiency 54 92.64 High High
Stroke 30 92.08 High High
Hepatocellular Cancer 1 90.56 High High
Bundle-branch Block 6 90.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Tiazofurin (2-B-D-Ribofuranosylthiazole-4-Carboxamide: NSC 286193) is a nucleoside antimetabolite that acts as a potent inhibitor of IMP dehydrogenase resulting in a guanine nucleotide deprivation.
Negative_regulation (inhibitor) of IMP
1) Confidence 0.57 Published 1990 Journal Sel Cancer Ther Section Abstract Doc Link 2343202 Disease Relevance 0.25 Pain Relevance 0.08
With LV dysfunction, we hypothesize that inotropic agents reduce the IMP by shortening isovolumic indices and possibly lengthening LVET (due to increased stroke volume) with a resultant increase in diastolic filling period.
Negative_regulation (reduce) of IMP associated with heart rate under development
2) Confidence 0.42 Published 2006 Journal Cardiovasc Ultrasound Section Body Doc Link PMC1654186 Disease Relevance 0.47 Pain Relevance 0.07
Similarly oral digoxin for 1 month resulted in a reduction in the IMP due to a 61% reduction in ICT.
Negative_regulation (reduction) of IMP
3) Confidence 0.42 Published 2006 Journal Cardiovasc Ultrasound Section Body Doc Link PMC1654186 Disease Relevance 0.42 Pain Relevance 0
IMP was markedly reduced with dobutamine infusion with reductions in both ICT and IRT despite a reduction in LVET.
Negative_regulation (reduced) of IMP
4) Confidence 0.42 Published 2006 Journal Cardiovasc Ultrasound Section Body Doc Link PMC1654186 Disease Relevance 0.42 Pain Relevance 0
There are a few studies in patients with nonischemic dilated cardiomyopathy and coronary disease patients post myocardial infarction in which dobutamine reduced IMP in patients with contractile reserve but not in patients who were ischemic [6,7].
Negative_regulation (reduced) of IMP associated with dilated cardiomyopathy, coronary heart disease and myocardial infarction
5) Confidence 0.31 Published 2006 Journal Cardiovasc Ultrasound Section Body Doc Link PMC1654186 Disease Relevance 0.58 Pain Relevance 0
IMP declined (Figure 2) due to marked shortening of the ICT, shortening of IRT, and shortening of LVET.
Negative_regulation (declined) of IMP
6) Confidence 0.31 Published 2006 Journal Cardiovasc Ultrasound Section Body Doc Link PMC1654186 Disease Relevance 0.49 Pain Relevance 0.03
Our study fills that void and demonstrates that IMP declines with dobutamine and digoxin due to a marked reduction in ICT using a model of mild LV dysfunction.
Negative_regulation (declines) of IMP
7) Confidence 0.31 Published 2006 Journal Cardiovasc Ultrasound Section Body Doc Link PMC1654186 Disease Relevance 0.46 Pain Relevance 0
On release of deep muscle retraction, there was a rapid decrease in IMP to preoperative levels.
Negative_regulation (decrease) of IMP in muscle
8) Confidence 0.16 Published 2004 Journal Neurosurgery Section Body Doc Link 15157298 Disease Relevance 0.06 Pain Relevance 0
Azathioprine (2.0 mg/kg/day [Imurel; Glaxo Wellcome]) was included in the therapy regimen from day 105 in combination with prednisolone to possibly lower the necessary dose of prednisolone (clinical signs of steroid associated adverse effects [polyuria, polydipsia, panting and Cushingoid appearence] were observed at the dosage needed for sufficient IMPA suppression).
Negative_regulation (suppression) of IMPA associated with polyuria and arthritis
9) Confidence 0.04 Published 2006 Journal Acta Vet Scand Section Body Doc Link PMC1553462 Disease Relevance 0.85 Pain Relevance 0.08
Inositol-lowering drugs, including mood-stabilizing drugs such as lithium, valproate and carbamazepine, can induce autophagy by inhibiting inositol monophosphatase (IMPase), leading to depletion of intracellular inositol levels and inhibition of the phospho-inositol cycle, as described above [23,73].
Negative_regulation (inhibiting) of inositol monophosphatase associated with carbamazepine
10) Confidence 0.01 Published 2010 Journal Seminars in Cell & Developmental Biology Section Body Doc Link PMC2938570 Disease Relevance 0.67 Pain Relevance 0.05
Inhibition of inositol monophosphatase (IMPase) reduces free inositol and IP3 levels, which leads to an upregulation of autophagy.
Negative_regulation (Inhibition) of inositol monophosphatase
11) Confidence 0.01 Published 2010 Journal Seminars in Cell & Developmental Biology Section Body Doc Link PMC2938570 Disease Relevance 0.52 Pain Relevance 0

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