INT228832

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.25
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 15
Disease Relevance 1.77
Pain Relevance 0.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Mxd1) nucleus (Mxd1) cytoplasm (Mxd1)
Anatomy Link Frequency
brain 2
Mxd1 (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 391 95.36 Very High Very High Very High
cocaine 40 83.80 Quite High
addiction 8 80.72 Quite High
Nucleus accumbens 152 57.72 Quite High
Ventral tegmentum 96 52.84 Quite High
dopamine receptor 48 49.00 Quite Low
Eae 16 43.64 Quite Low
amygdala 8 38.28 Quite Low
Central nervous system 20 5.00 Very Low Very Low Very Low
imagery 16 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 65 100.00 Very High Very High Very High
Rheumatoid Arthritis 5 95.12 Very High Very High Very High
Herpes Simplex Virus 10 91.04 High High
Sprains And Strains 32 86.72 High High
Congenital Anomalies 21 80.24 Quite High
Stress 15 77.84 Quite High
Cyst 36 75.08 Quite High
Urological Neuroanatomy 8 49.96 Quite Low
Anxiety Disorder 16 38.96 Quite Low
Aggression 24 36.56 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This effect was clearly seen when neglectful pups were being raised by either previously nurturing MaD1 (H (1,22)?
Gene_expression (raised) of MaD1
1) Confidence 0.25 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2276864 Disease Relevance 0 Pain Relevance 0
Birth rate is also similar in both MaD1 and Outbred-S mice (Fig. 1B), indicating a fertility related issue is not likely the basis for neglect.
Gene_expression (similar) of MaD1
2) Confidence 0.25 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2276864 Disease Relevance 0.08 Pain Relevance 0.10
When comparing proportion of nurturing MaD1 pups weaned between neglectful and nurturing MaD1 mothers, heightened neglect was seen in the neglectful mothers but this did not reach significance (p?
Gene_expression (mothers) of MaD1
3) Confidence 0.25 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2276864 Disease Relevance 0 Pain Relevance 0
Unexpectedly, pups born to previously neglectful (relative to nurturing) MaD1 mothers were significantly more likely to receive maternal neglect (F (1,50)?
Gene_expression (mothers) of MaD1
4) Confidence 0.25 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2276864 Disease Relevance 0 Pain Relevance 0
This effect was again seen when neglectful pups were raised by either previously nurturing MaD1 (H (1,22)?
Gene_expression (raised) of MaD1
5) Confidence 0.25 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2276864 Disease Relevance 0 Pain Relevance 0
When comparing proportion of nurturing MaD1 pups weaned between neglectful and nurturing MaD1 mothers, heightened neglect was seen in the neglectful mothers but this did not reach significance (p?
Gene_expression (pups) of MaD1
6) Confidence 0.25 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2276864 Disease Relevance 0 Pain Relevance 0
Previously nurturing MaD1 and Outbred-S mothers also cared for these three groups.
Gene_expression (nurturing) of MaD1
7) Confidence 0.25 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2276864 Disease Relevance 0.09 Pain Relevance 0
In each generation of MaD1 mice, we observe extreme neglect in a consistent proportion of the population and the background population from which MaD1 mice were derived may have altered dopamine signaling, for review, see [67].
Gene_expression (generation) of MaD1 associated with dopamine
8) Confidence 0.22 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2276864 Disease Relevance 0 Pain Relevance 0.42
The co-transfection of Foxl2-Mad attenuated the ability of Foxl2-VP16 to activate luciferase expression by 95% (data not shown).
Gene_expression (transfection) of Mad
9) Confidence 0.15 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2831895 Disease Relevance 0.24 Pain Relevance 0
The finding that only 2 out of the 12 were activated by Mad domain repression suggests that Foxl2-Mad functions more reliably as a repressor in comparison to Foxl2-VP16 as an activator in our study.
Gene_expression (repression) of Mad associated with repression
10) Confidence 0.13 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2831895 Disease Relevance 0.46 Pain Relevance 0
Levels of gene expression were compared between mock transfected cells and those that were transfected with Foxl2-VP16 and Foxl2-MAD, respectively.
Gene_expression (transfected) of MAD
11) Confidence 0.13 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2831895 Disease Relevance 0.25 Pain Relevance 0
g of Foxl2-MAD expression vector in 30 ?
Gene_expression (expression) of MAD
12) Confidence 0.13 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2831895 Disease Relevance 0.14 Pain Relevance 0
Mad transfected cells (group NR); and Mad vs.
Gene_expression (transfected) of Mad
13) Confidence 0.12 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2831895 Disease Relevance 0.23 Pain Relevance 0
Putative NOS-immunoreactivity (NOS-IR) was distributed throughout the brain of both MAD and normal gammarids (Fig. 4).
Gene_expression (brain) of MAD in brain
14) Confidence 0.04 Published 2010 Journal Parasit Vectors Section Body Doc Link PMC2874546 Disease Relevance 0.27 Pain Relevance 0
However, the intensity of the NOS punctate label was increased in the tissues adjacent to mature metacercariae in the brain of MAD gammarids (Fig. 4d to 4j).
Gene_expression (gammarids) of MAD in brain
15) Confidence 0.04 Published 2010 Journal Parasit Vectors Section Body Doc Link PMC2874546 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox